Sprofondamenti in aree urbane: il caso del parco “Ytzhak Rabin” (via Panama, Roma)

In Rome urban area, within the garden dedicated to Ytzhak Rabin (a portion of the Villa Ada park), occurrence of a few collapses has been observed for the first time in September 2012. In the surroundings, presence of underground cavities- mainly catacombs- is conversely well documented by previous studies. Local authorities were immediately informed of sinkholes formation, because collapses occurred very close to a playground located in a highly frequented sector of the garden. Propagation processes of the phenomena, periodically monitored since their first observation, significantly fastened after a period of heavy rainfalls on Rome area in January- February 2014. Thus, multidisciplinary geophysical investigations have been started in agreement with Civil Protection of Rome Municipality, who has taken preliminary safety measures (installation of fences and danger signals). Hitherto, 28 sinkholes have been identified, aligned along a WNW-ESE trending zone, testifying localized collapses of the roof of underground cavities, probably belonging to the palaeocristian catacomb systems dug nearby Via Salaria. Preliminary geophysical prospections have been performed in a small test area, in order to verify methods applicability and thus program a systematic survey of the whole garden. Drillings, and direct exploration of the accessible galleries, will complete the reconstruction of underground geometry and conservation state of vaults and pillars. Once completed the hazard assessment, the planning of urgent works is expected in order to restore the complete use of the garden.Published25 - 422TR. Ricostruzione e modellazione della struttura crostaleN/A or not JC

Real life turnaround time of blood cultures in the clinical microbiology laboratory: results of the first Italian survey, May 2015

Background and aims: Blood culture (BC) results are essential to guide antimicrobial chemotherapy for patients with sepsis. However, BC is a time-consuming exam, which can take several days. Reducing BCs turn around time (TAT) could impact on multiple outcome parameters and TAT monitoring is an important tool for measurement of microbiology laboratory performance. The aim of this study was to provide an overview of BC TATs among Italian microbiology laboratories. Materials and methods: Five laboratories collected and recorded, for a month period, date and time of the BC processing events. Cumulative TATs were analysed using the GraphPad software. Results: Participating laboratories reported data from 302 sepsis episodes. The median time from when the BC system produced a positive signal until Gram-stain results were reported was 7.6 hours. A rapid molecular identification and antimicrobial susceptibility testing (AST) was performed in 26.5% of BCs. Mean TAT for identification report was significantly lower when a molecular approach was adopted (12 vs. 28.7 hours, P<0.001). Similarly, results of the molecular AST were obtained more than 24 hours in advance compared with phenotypic AST (mean 13.2 vs. 47.6, P<0.001). TATs from BC positivity of laboratories opened 7 days/week were not significantly lower than those of laboratories opened 6 days/week. Conclusions: BC is a time-consuming exam, however, molecular identification and AST methods can drastically reduce time to results. The lack of difference between TATs observed for laboratories working 7 days/week and 6 days/week, coupled with a high rate of BCs turning positive during the night enable to conclude that the most urgent measure to reduce TATs is the expansion of laboratory regular duty hours

Indagini geofisiche e geochimiche di un sinkhole in formazione nell’area di Guidonia (Lazio)

The Plio-Quaternary Acque Albule Basin is already known for the occurrence of sinkholes; since the spring 2014, it has been ongoing the study of an active subsidence process, which formed a depressed area near the Guidonia village. During the last year, the phenomenon has become more intense giving rise to two collapses along the eastern rim of the depression. Thus, geophysical and geogeochemical investigation campaigns started in order to understand the genesis and evolution of the phenomenon. Survey results allowed a geological and structural characterization, showing the presence of “travertino” at the depression margins and its absence therein. It has been recognized, by the geophysics, features with NW-SE and NNE-SSW direction ascribable to a possible depression fracturing and consistent with regional structural trends. Thus, it has been possible to plan and perform geognostic investigation consisting in two drillings aimed to define the stratigraphy of the marginal and inner part of the depression.Published7 - 162TR. Ricostruzione e modellazione della struttura crostaleJCR Journa

Brassicaceae: a rich source of health improving phytochemicals

Abstract Brassicaceae Burnett (syn. Cruciferae A.L. de Jussieu) include many important economic plants used as edible or ornamental which are commonly known as the ‘‘mustard’’ plant family due to the sharp, potent flavour of their sulfur metabolites, the glucosinolates. Brassicas also produce phenolics, tocopherols and peculiar seed oils. Current scientific knowledge attributes to species belonging to this botanical family several health benefits such as reduced risk of cancer. This review summarizes information on the phytochemical profile of Brassicaceae plants, with a special regard to glucosinolates and their derived degradation products, the isothiocyanates. In addition, their role as antioxidant and cancer protective metabolites is discussed

Glucosinolates from Brassicaceae of Mediterranean diet

Plants of the Brassicaceae family are widespread in the Mediterranean regions where they are widely consumed cooked (cauliflowers, broccoli, turnips) or as salads or condiments. These plants are a good source of bioactive compounds of nutraceutical relevance1,2. Among them the glucosinolates (GLS), responsible for the plant pungent aroma and bitter taste, are of particular interest. GLS are the most studied bioactive compounds in the Brassicaceae family and epidemiological studies have shown an inverse correlation between consumption of brassica plants and risk of cancer3. We have focused our attention on three Brassicaceae, B. oleracea, B. rapa, and Eruca sativa traditionally eaten in Puglia. The edible inflorescences of B.oleracea var italica, locally called “mugnolo” and traditionally cultivated in Salento, are characterized by the presence of the aliphatic GLSs glucoraphanin (1.79 μmol/g), glucoiberin, glucoerucin, and sinigrin, and by a good content of the aromatic GLSs glucobarberin (0.56 μmol/g) and gluconasturtin, and of the indole GLSs glucobrassicin (3.51 μmol/g), neoglucobrassicin, 4-methoxyglucobrassicin, and 4- hydroxyglucobrassicin2. In the leaves of Eruca sativa, particularly consumed as salad, the most abundant GLS is glucoraphanin. In the aerial parts of B.rapa there are three predominant GLSs: two indole GLS neoglucobrassicin (1.65 μmol/g) and glucobrassicin (0.97 μmol/g) and the aliphatic GLS gluconapin (1.13 μmol/g). Given the importance of Brassicaceae for their content in GLSs, we have also studied the accumulation of these metabolites during the different stages of growth taken B. rapa as plant model. The aerial parts of B. rapa have been found to contain more GLS during the budding stage. Moreover we have observed that at budding indole GLSs are dominant while at flowering there are more aliphatic GLSs. This gives an added value to B. rapa since it’s known that hydrolysis products from the indole GLSs have anticarcinogenic properties by induction of phase I or phase II detoxification enzymes4

Studio fitochimico di specie della tradizione mediterranea

plants of Capparales (or Brassicales) are widespread in the Mediterranean region where they are widely consumed cooked or as salad vegetables (cabbage, Brussels sprouts, cauliflower, broccoli) or as condiments (horseradish, mustard, capers). these plants are a good source of bioactive compounds such as glucosinolates, vitamins, flavonoids, minerals. glucosinolates are responsible for pungent and bitter taste of Brassicaceae and are the most extensively studied bioactive compounds for their potential as anticarcinogens due to their hydrolysis products, the isothiocyanates. this study describes the chemical profile of a poorly studied variety of Brassica oleracea, traditionally cultivated in Southern italy and locally called “mugnolo”, and of Capparis spinosa subsp rupestris. it was found that “mugnolo” inflorescences are characterized by aliphatic, aromatic and indole glucosinolates. among them the indole glucosinolates (7.68 μmol/g) are predominant, while aliphatic and aromatic glucosinolates are found in low quantities, 2.63 μmol/g and 0.83 μmol/g respectively. chemical composition of seeds and aerial parts of C. spinosa subsp rupestris was also determined. it was found that the principal glucosinolate of the seeds is the glucocapparin, moreover the seeds oil is rich in unsaturated and rare lipids such as cis-vaccenic acid. the aerial parts are characterized by rutin as predominant flavonoid

Biodiversità vegetale: fitocomposti e salute

Endemismi e biodiversità vegetali rappresentano un patrimonio di altissimo valore da preservare con attenzione e valorizzare per i numerosi benefici che ne derivano non solo all’ambiente, ma anche in campo economico industriale. Il mondo vegetale, attraverso la sua diversità biologica, costituisce infatti un’ampia risorsa di materie prime utilizzate in agricoltura, medicina e farmacia. Le piante sintetizzano ed accumulano un vasto numero di metaboliti secondari, strutturalmente differenti ed espressione dell’individualità della specie, che sono responsabili delle caratteristiche proprietà ecologiche ed implicati nel controllo di funzioni essenziali per la pianta quali crescita e riproduzione. Molti metaboliti secondari hanno inoltre attività farmacologiche. Il crescente interesse verso la fitoterapia e l’elevata richiesta di prodotti per la salute di origine naturale ha indirizzato in questi ultimi anni la ricerca farmacobotanica verso lo studio della biodiversità vegetale allo scopo di scoprire nuove molecole bioattive e/o fitocomposti da utilizzare come leads per lo sviluppo di prodotti per la salute e farmaci innovativi. La presente comunicazione si propone di fornire una breve rassegna di specie vegetali di interesse fitofarmaceutico evidenziandone il polimorfismo fitochimico derivante dalla loro biodiversità. La tematica verrà discussa facendo riferimento sia a specie vegetali spontanee che a specie coltivate, alcune con una larga tradizione in fitoterapia, altre di più recente applicazione dando risalto alla loro importanza nella promozione del benessere e nella ricerca di nuove cure. SESSIONE

Oleaginose in campo farmaceutico e cosmetico. In: Oli e grassi - Fonti oleaginose per gli utilizzi food e non food a cura di Giuliano Mosca - Edagricole – Edizioni Agricole di New Business Media srl

La stragrande quantità di oli e di acidi grassi sono impiegati dall’industria alimentare per il consumo diretto, la preparazione di fritture, salse e vivande. Una quota di circa il 5% è impiegata per l’alimentazione di animali e circa il 10% per la produzione di creme, saponi, detergenti o composti simili a scopo sia cosmetico che terapeutico. Gli oli vegetali sono ottenuti per spremitura a freddo di droghe vegetali i cui principi attivi sono caratterizzati da consistenza oleosa. Gli oli vegetali sono costituiti prevalentemente da trigliceridi ricchi in acidi grassi saturi ed insaturi, ma sono presenti anche sostanze antiossidanti, vitamine liposolubili e la cosiddetta frazione insaponificabile, ovvero una miscela di sostanze di estremo interesse sia dal punto di vista dermatologico, cosmetico e farmaceutico