Comparison of different adherence cutoff values for the prediction of detectable plasma viral load.

<p>¹pVL, plasma viral load.</p><p>²Shown are % (proportions) of patients with adherence higher than or equal to the respective adherence threshold.</p><p>Comparison of different adherence cutoff values for the prediction of detectable plasma viral load.</p

Factors associated with suboptimal adherence to ART.

<p>¹Data are % (proportion) of patients or median value (interquartile range).</p><p>Factors associated with suboptimal adherence to ART.</p

Characteristics of the patients.

<p>¹Data are medians (interquartile ranges) for continuous variables and % (proportions) for discrete variables.</p><p>²Triple NRTI (n = 9), PI+NNRTI-based (n = 5).</p><p>Characteristics of the patients.</p

Effects of adherence on virological suppression among patients with high versus low or intermediate CD4+ T cell counts.

<p>¹pVL, plasma viral load.</p><p>²Patient numbers are shown.</p><p>Effects of adherence on virological suppression among patients with high versus low or intermediate CD4+ T cell counts.</p

Additional file 1: Table S1. of Widespread hepatitis B virus genotype G (HBV-G) infection during the early years of the HIV epidemic in the Netherlands among men who have sex with men

Contains the sequences of the PCR-primers used in the study. (XLS 39 kb

Additional file 1: Table S1. of Widespread hepatitis B virus genotype G (HBV-G) infection during the early years of the HIV epidemic in the Netherlands among men who have sex with men

Contains the sequences of the PCR-primers used in the study. (XLS 39 kb

Data_Sheet_1_Transmission of anelloviruses to HIV-1 infected children.docx

Anelloviruses (AVs) are widespread in the population and infect humans at the early stage of life. The mode of transmission of AVs is still unknown, however, mother-to-child transmission, e.g., via breastfeeding, is one of the likely infection routes. To determine whether the mother-to-child transmission of AVs may still occur despite the absence of natural birth and breastfeeding, 29 serum samples from five HIV-1-positive mother and child pairs were Illumina-sequenced. The Illumina reads were mapped to an AV lineage database “Anellometrix” containing 502 distinct ORF1 sequences. Although the majority of lineages from the mother were not shared with the child, the mother and child anellomes did display a significant similarity. These findings suggest that AVs may be transmitted from mothers to their children via different routes than delivery or breastfeeding.</p

Table_1_Transmission of anelloviruses to HIV-1 infected children.XLSX

Anelloviruses (AVs) are widespread in the population and infect humans at the early stage of life. The mode of transmission of AVs is still unknown, however, mother-to-child transmission, e.g., via breastfeeding, is one of the likely infection routes. To determine whether the mother-to-child transmission of AVs may still occur despite the absence of natural birth and breastfeeding, 29 serum samples from five HIV-1-positive mother and child pairs were Illumina-sequenced. The Illumina reads were mapped to an AV lineage database “Anellometrix” containing 502 distinct ORF1 sequences. Although the majority of lineages from the mother were not shared with the child, the mother and child anellomes did display a significant similarity. These findings suggest that AVs may be transmitted from mothers to their children via different routes than delivery or breastfeeding.</p

AIDS-free and CXCR4-free survival from HIV-1 seroconversion with and without <i>BSSL</i> HH genotype.

<p>Kaplan Meier estimation of patients with HH and non-HH (LL+LH) genotypes using (A+B) AIDS-free survival plotted for (A) all genotypes (LL n = 47, LH n = 139, HH n = 139, log rank p = 0.063), (B) HH versus LL+LH genotypes (HH n = 139, non-HH n = 186) (log rank p = 0.033) or (C+D) first detection of CXCR4-using HIV-1 variants as an endpoint for (C) all genotypes (LL n = 41, LH n = 126, HH n = 127, log rank p = 0.106) or (D) HH versus LL+LH genotypes (HH n = 127, non-HH n = 167, log rank p = 0.085).</p

<i>BSSL</i> HH genotype is associated with high CD4 cell numbers pre-seroconversion.

<p>The relation between <i>BSSL</i> genotypes and CD4 cell count before seroconversion for individuals with the (A) LL, LH and HH genotypes (p = 0.022) and (B) HH versus non-HH (LL+LH) genotypes (p = 0.007). Median values are indicated with a horizontal line. NS: not significant, *: p<0.05, **, p<0.01.</p