393 research outputs found
Using the Embodiment-Projection-Role Paradigm within Drama Therapy to Develop Affective Social Competence in Children
Affective Social Competence (ASC) is a dynamic, interconnected model of socio-emotional skill, articulating the development of emotional expression (EE), understanding (EU), and regulation (ER) (Halberstadt, Denham, & Dunsmore, 2001). This theoretical research paper uses integrative literature review and intervention research methodologies to identify how play, in the context of drama therapy, can support the development of ASC. Research indicates that elements of play are related to growth in ASC subdomains, including social play with peers and parents, and physical, object, and pretend play experiences. Based on this research, the Embodiment-Projection-Role (EPR) paradigm is identified as an ideal framework for building ASC drama therapeutically (Jennings, 1990; 1998; 1999; 2005; 2011; 2012a; 2012b). Specifically, Embodiment Play, using movement and sensory exploration of the environment, supports emotion regulation, helping the child explore physiological and emotional experiences and practice coping and regulation strategies. Projective Play, externalizing ideas and experiences onto toys and objects to manipulate them, supports emotional expression. It assists in the expression and mastery of emotional content for children through symbols. Role Play is related to emotion understanding, which requires the ability to take the perspective of another, and decode emotions. Through pretending to be someone else, children strengthen their abilities to role reverse, empathize, and understand the emotions of others. A program for building ASC in children aged four to ten using the EPR paradigm is described, including client and therapist roles, setting and materials, goals, exercises, and session structures
Navigating distance learning technologies using team teaching
In 2004, the American Association of Colleges of Nursing (AACN) adopted the position to move the current level of preparation necessary for advanced practice nurse (APN) roles from the master\u27s degree to the doctoral level. AACN also called for educating APNs and other nurses seeking top leadership and clinical roles in Doctor of Nursing Practice (DNP) Programs.
In September 2007, the Jefferson School of Nursing welcomed its first cohort of 18 DNP students. Students represented a wide variety of practice specialties including acute care, primary care, healthcare administration, population health, education and industry. Twenty students comprise the second cohort entering in September 2008. Nationwide, Jefferson is one of 79 schools of nursing offering a DNP degree
Recommended from our members
A phase II study of temsirolimus and liposomal doxorubicin for patients with recurrent and refractory bone and soft tissue sarcomas
Background
Relapsed and refractory sarcomas continue to have poor survival rates. The cancer stem cell (CSC) theory provides a tractable explanation for the observation that recurrences occur despite dramatic responses to upfront chemotherapy. Preclinical studies demonstrated that inhibition of the mechanistic target of rapamycin (mTOR) sensitizes the CSC population to chemotherapy.
Methods
Here we present the results of the Phase II portion of a Phase I/II clinical trial that aimed to overcome the chemoresistance of sarcoma CSC by combining the mTOR inhibitor temsirolimus (20 mg/m2 weekly) with the chemotherapeutic agent liposomal doxorubicin (30 mg/m2 monthly).
Results
Fifteen patients with relapsed/refractory sarcoma were evaluable at this recommended Phase 2 dose level. The median progression free survival was 315 days (range 27–799). Response rate, defined as stable disease or better for 60 days, was 53%. Nine of the patients had been previously treated with doxorubicin. Therapy was well tolerated. In a small number of patients, pre- and post- treatment tumor biopsies were available for assessment of ALDH expression as a marker of CSCs and showed a correlation between response and decreased ALDH expression. We also found a correlation between biopsy-proven inhibition of mTOR and response.
Conclusions
Our study adds to the literature supporting the addition of mTOR inhibition to chemotherapy agents for the treatment of sarcomas, and proposes that a mechanism by which mTOR inhibition enhances the efficacy of chemotherapy may be through sensitizing the chemoresistant CSC population. Further study, ideally with pre- and post-therapy assessment of ALDH expression in tumor cells, is warranted.
Trial registration The trial was registered on clinicaltrials.gov (NCT00949325) on 30 July 2009. http://www.editorialmanager.com/csrj/default.asp
Exome Sequencing of a Multigenerational Human Pedigree
Over the next few years, the efficient use of next-generation sequencing (NGS) in human genetics research will depend heavily upon the effective mechanisms for the selective enrichment of genomic regions of interest. Recently, comprehensive exome capture arrays have become available for targeting approximately 33 Mb or ∼180,000 coding exons across the human genome. Selective genomic enrichment of the human exome offers an attractive option for new experimental designs aiming to quickly identify potential disease-associated genetic variants, especially in family-based studies. We have evaluated a 2.1 M feature human exome capture array on eight individuals from a three-generation family pedigree. We were able to cover up to 98% of the targeted bases at a long-read sequence read depth of ≥3, 86% at a read depth of ≥10, and over 50% of all targets were covered with ≥20 reads. We identified up to 14,284 SNPs and small indels per individual exome, with up to 1,679 of these representing putative novel polymorphisms. Applying the conservative genotype calling approach HCDiff, the average rate of detection of a variant allele based on Illumina 1 M BeadChips genotypes was 95.2% at ≥10x sequence. Further, we propose an advantageous genotype calling strategy for low covered targets that empirically determines cut-off thresholds at a given coverage depth based on existing genotype data. Application of this method was able to detect >99% of SNPs covered ≥8x. Our results offer guidance for “real-world” applications in human genetics and provide further evidence that microarray-based exome capture is an efficient and reliable method to enrich for chromosomal regions of interest in next-generation sequencing experiments
Recommended from our members
NBS monograph
From Abstract: "This monograph deals with the formulation and development of the new highly stable nickel-base thermocouple alloys Nicrosil (Ni-14.2Cr-1.4Si) and Nisil (Ni-4.4Si-0.1Mg) under the leadership of the Materials Research Laboratories (MRL) of the Australian Government of Defence, and their standardization by the National Bureau of Standards (NBS) of the U.S. Department of Commerce.
Nurses Alumni Association Bulletin, Fall 1991
Annual Meeting Calendar
Annual Luncheon - Meeting Notice
Meeting Notice Dates
Officers and Committee Chairmen
President\u27s Message
Treasurer\u27s Report
Proposed Budget- 1991
News About Our Graduates
History of the School of Nursing
The Future of Nursing
School Health - 20 Years Ago - Today
Happy Birthday
Resume of Minutes of Alumni Association Meetings
Alumni Office News
Committee Reports By-Laws
Bulletin
Nominating
Relief Fund
Satellite
Scholarship
Social
Finance
Nursing Education at Jefferson - A Century of Excellence
The Decade Fund
Fiftieth Anniversary
In Memoriam, Names of Deceased Graduates
Luncheon Photos
My Dear Son
Weather Lore
Class News
Scholarship Application
Non-Graduate Scholarship Fund Application
Relief Fund Application
Centennial Tile Order Form
Membership Application
Pins, Transcripts, Class Address Lists, Change of Address Form
Ma
Nurses Alumni Association Bulletin, Fall 1988
Alumni Meeting Calendar
Officers and Committee Chairmen
The President\u27s Message
The Jefferson Hospital School Of Nursing Roll Of Honor
Treasurer\u27s Report
Glimpses From An Earlier Time
Accentuate The Positive
I Have Noticed
Reaching A Cherished Goal
Special Achievement Award
Archives And The Nursing Experience
Happy Birthday
Fiftieth Anniversary
CAHS Alumni Directory.
Resume Of Minutes Of Alumni Association Meetings
Alumni Office News
Committee Reports
Relief Fund
Satellite
Scholarship
Social
Bulletin
Finance
Do Something
Volunteers Needed
Bequests
Have We Changed?
The Original Coal Miners Daughter Remembers
Congratulations From The Alumni Association
Luncheon Photos
The Butterfly And The Caterpillar
Forty Three Attend Fortieth
In Memoriam, Names of Deceased Graduates
Class News
Change of Address Form
Pins, Transcripts, Class Address List
Relief Fund Application
Scholarship Fund Application
The Jefferson Hospital School of Nursing Roll of Honor Nomination Application
Membership Application
Ma
Light smoking at base-line predicts a higher mortality risk to women than to men; evidence from a cohort with long follow-up
BACKGROUND: There is conflicting evidence as to whether smoking is more harmful to women than to men. The UK Cotton Workers’ Cohort was recruited in the 1960s and contained a high proportion of men and women smokers who were well matched in terms of age, job and length of time in job. The cohort has been followed up for 42 years. METHODS: Mortality in the cohort was analysed using an individual relative survival method and Cox regression. Whether smoking, ascertained at baseline in the 1960s, was more hazardous to women than to men was examined by estimating the relative risk ratio women to men, smokers to never smoked, for light (1–14), medium (15–24), heavy (25+ cigarettes per day) and former smoking. RESULTS: For all-cause mortality relative risk ratios were 1.35 for light smoking at baseline (95% CI 1.07-1.70), 1.15 for medium smoking (95% CI 0.89-1.49) and 1.00 for heavy smoking (95% CI 0.63-1.61). Relative risk ratios for light smoking at baseline for circulatory system disease was 1.42 (95% CI 1.01 to 1.98) and for respiratory disease was 1.89 (95% CI 0.99 to 3.63). Heights of participants provided no explanation for the gender difference. CONCLUSIONS: Light smoking at baseline was shown to be significantly more hazardous to women than to men but the effect decreased as consumption increased indicating a dose response relationship. Heavy smoking was equally hazardous to both genders. This result may help explain the conflicting evidence seen elsewhere. However gender differences in smoking cessation may provide an alternative explanation
Design and validation of a supragenome array for determination of the genomic content of Haemophilus influenzae isolates
Abstract
Background
Haemophilus influenzae colonizes the human nasopharynx as a commensal, and is etiologically associated with numerous opportunistic infections of the airway; it is also less commonly associated with invasive disease. Clinical isolates of H. influenzae display extensive genomic diversity and plasticity. The development of strategies to successfully prevent, diagnose and treat H. influenzae infections depends on tools to ascertain the gene content of individual isolates.
Results
We describe and validate a Haemophilus influenzae supragenome hybridization (SGH) array that can be used to characterize the full genic complement of any strain within the species, as well as strains from several highly related species. The array contains 31,307 probes that collectively cover essentially all alleles of the 2890 gene clusters identified from the whole genome sequencing of 24 clinical H. influenzae strains. The finite supragenome model predicts that these data include greater than 85% of all non-rare genes (where rare genes are defined as those present in less than 10% of sequenced strains). The veracity of the array was tested by comparing the whole genome sequences of eight strains with their hybridization data obtained using the supragenome array. The array predictions were correct and reproducible for ~ 98% of the gene content of all of the sequenced strains. This technology was then applied to an investigation of the gene content of 193 geographically and clinically diverse H. influenzae clinical strains. These strains came from multiple locations from five different continents and Papua New Guinea and include isolates from: the middle ears of persons with otitis media and otorrhea; lung aspirates and sputum samples from pneumonia and COPD patients, blood specimens from patients with sepsis; cerebrospinal fluid from patients with meningitis, as well as from pharyngeal specimens from healthy persons.
Conclusions
These analyses provided the most comprehensive and detailed genomic/phylogenetic look at this species to date, and identified a subset of highly divergent strains that form a separate lineage within the species. This array provides a cost-effective and high-throughput tool to determine the gene content of any H. influenzae isolate or lineage. Furthermore, the method for probe selection can be applied to any species, given a group of available whole genome sequences.http://deepblue.lib.umich.edu/bitstream/2027.42/112375/1/12864_2012_Article_5193.pd
- …