Associations between high BMI and large WC of 8-and-12-year-old children and total and HDL cholesterol concentrations and total-to HDL cholesterol ratio in 12-year-old girls and boys compared with girls and boys with a normal BMI or WC at both ages (normal-normal).

<p>BMI: body mass index, WC, waist circumference, HDL: high density lipoprotein.</p><p>Model B: adjusted for pre-pregnancy maternal overweight, puberty development scale, age at the time of the measurements, height.</p><p>Model C: additionally adjusted for WC (in BMI analyses) and BMI (in WC analyses).</p

Associations between high BMI and large WC of 8-and-12-year old children and systolic and diastolic blood pressure in 12-year-old girls and boys compared with girls and boys with a normal BMI or WC at both ages (normal-normal).

<p>BMI: body mass index, WC, waist circumference, BP: blood pressure.</p><p>Model B: adjusted for cuff size, pre-pregnancy maternal overweight, puberty development scale, age at the time of the measurements, height.</p><p>Model C: additionally adjusted for WC (in BMI analyses) and BMI (in WC analyses).</p

Flow chart.

<p>Flow chart.</p

General characteristics of the study population, separately for girls and boys.

*<p>The PDS ranges from 1 to 5 where a score of 1 indicates that puberty has not started yet and a score of 5 indicates that the puberty development seems complete. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051801#pone.0051801-Carskadon1" target="_blank">[19]</a>.</p>**<p>The International Diabetes Federation provides thresholds for defining children at risk of future cardiovascular disease for HDL cholesterol and blood pressure. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0051801#pone.0051801-Zimmet1" target="_blank">[28]</a>.</p>***<p>Allergic mother: ≥1 time yes to ‘ever asthma’, ‘allergy to pets’, ‘allergy to house dust mite’, or ‘nose allergy like hay fever’.</p>****<p>Regions: North: provinces Groningen, Friesland, Drenthe; West: region of Rotterdam; Middle: provinces Utrecht and Gelderland.</p