6 research outputs found
Estimated reporting sensitivity of the Czech IPD surveillance system by source of reporting and in total, 2010 to 2013.
<p>Error bars reflect 95% confidence intervals.</p
Estimated sensitivity of IPD reporting stratified by region according to the Nomenclature of Units for Territorial Statistics (NUTS 2), 2013, CZ.
<p>Error bars reflect 95% confidence intervals.</p
Number of reported and estimated IPD cases in the CZ according to reporting source (EPIDAT, NRL) from 2010 to 2013.
<p>+ = captured by this source; - = not captured by this source.</p
Timeline of events related to the introduction of PCV vaccination and IPD surveillance in the Czech Republic, 2005–2013.
<p>* Licensed and available on the private market.</p
Structure and levels of the Czech IPD surveillance system, based on two reporting sources.
<p>NRL = National Reference Laboratory for streptococcal infections, EPIDAT = Czech national epidemiological database, MoH = Ministry of Health, TESSy = The European Surveillance System.</p
Influence of Surface Groups on Poly(propylene imine) Dendrimers Antiprion Activity
Prion diseases are characterized by the accumulation
of PrP<sup>Sc</sup>, an aberrantly folded isoform of the host protein
PrP<sup>C</sup>. Specific forms of synthetic molecules known as dendrimers
are able to eliminate protease-resistant PrP<sup>Sc</sup> in both
an intracellular and in vitro setting. The properties of a dendrimer
which govern this ability are unknown. We addressed the issue by comparing
the in vitro antiprion ability of numerous modified poly(propylene-imine)
dendrimers, which varied in size, structure, charge, and surface group
composition. Several of the modified dendrimers, including an anionic
glycodendrimer, reduced the level of protease resistant PrP<sup>Sc</sup> in a prion strain-dependent manner. This led to the formulation
of a new working model for dendrimer/prion interactions which proposes
dendrimers eliminate PrP<sup>Sc</sup> by destabilizing the protein
and rendering it susceptible to proteolysis. This ability is not dependent
on any particular charge of dendrimer, but does require a high density
of reactive surface groups