Heparin binding domain in vitronectin is required for oligomerization and thus enhances integrin mediated cell adhesion and spreading

AbstractVitronectin is a multi-functional protein found predominantly as a monomer in blood and as an oligomer in the extracellular matrix. We have dissected the minimal regions of vitronectin protein needed for effective integrin dependent cell adhesion and spreading. A fragment of vitronectin containing the RGD integrin binding site showed similar binding affinity as that of full vitronectin protein to purified integrin αvβ3 but had diminished cell adhesion and spreading function in vivo. We demonstrate that the oligomeric state of the protein is responsible for this effect. We provide compelling evidence for the involvement of the heparin binding domain of vitronectin in the oligomerization process and show that such oligomerization reinforces the activity of vitronectin in cell adhesion and spreading.Structured summaryMINT-7905703: Vn (uniprotkb:P04004) and Vn (uniprotkb:P04004) bind (MI:0407) by molecular sieving (MI:0071

A Brief Review on Dark Matter Annihilation Explanation for e±e^\pm Excesses in Cosmic Ray

Recently data from PAMELA, ATIC, FERMI-LAT and HESS show that there are $e^{\pm}$ excesses in the cosmic ray energy spectrum. PAMELA observed excesses only in $e^+$, but not in anti-proton spectrum. ATIC, FERMI-LAT and HESS observed excesses in $e^++e^-$ spectrum, but the detailed shapes are different which requires future experimental observations to pin down the correct data set. Nevertheless a lot of efforts have been made to explain the observed $e^\pm$ excesses, and also why PAMELA only observed excesses in $e^+$ but not in anti-proton. In this brief review we discuss one of the most popular mechanisms to explain the data, the dark matter annihilation. It has long been known that about 23% of our universe is made of relic dark matter. If the relic dark matter was thermally produced, the annihilation rate is constrained resulting in the need of a large boost factor to explain the data. We will discuss in detail how a large boost factor can be obtained by the Sommerfeld and Briet-Wigner enhancement mechanisms. Some implications for particle physics model buildings will also be discussed.Comment: 22 pages, 6 figures. Several typoes corrected and some references added. Published in Mod. Phys. Lett. A, Vol. 24, No. 27 (2009) pp. 2139-216

Decaying Hidden Dark Matter in Warped Compactification

The recent PAMELA and ATIC/Fermi/HESS experiments have observed an excess of electrons and positrons, but not anti-protons, in the high energy cosmic rays. To explain this result, we construct a decaying hidden dark matter model in string theory compactification that incorporates the following two ingredients, the hidden dark matter scenario in warped compactification and the phenomenological proposal of hidden light particles that decay to the Standard Model. In this model, on higher dimensional warped branes, various warped Kaluza-Klein particles and the zero-mode of gauge field play roles of the hidden dark matter or mediators to the Standard Model.Comment: 15 pages; v4, several clarifications added, update on Fermi/HESS result

Snowmass CF1 Summary: WIMP Dark Matter Direct Detection

As part of the Snowmass process, the Cosmic Frontier WIMP Direct Detection subgroup (CF1) has drawn on input from the Cosmic Frontier and the broader Particle Physics community to produce this document. The charge to CF1 was (a) to summarize the current status and projected sensitivity of WIMP direct detection experiments worldwide, (b) motivate WIMP dark matter searches over a broad parameter space by examining a spectrum of WIMP models, (c) establish a community consensus on the type of experimental program required to explore that parameter space, and (d) identify the common infrastructure required to practically meet those goals.Comment: Snowmass CF1 Final Summary Report: 47 pages and 28 figures with a 5 page appendix on instrumentation R&

Two component dark matter

We explain the PAMELA positron excess and the PPB-BETS/ATIC e+ + e- data using a simple two component dark matter model (2DM). The two particle species in the dark matter sector are assumed to be in thermal equilibrium in the early universe. While one particle is stable and is the present day dark matter, the second one is metastable and decays after the universe is 10^-8 s old. In this model it is simple to accommodate the large boost factors required to explain the PAMELA positron excess without the need for large spikes in the local dark matter density. We provide the constraints on the parameters of the model and comment on possible signals at future colliders.Comment: 6 pages, 2 figures, discussion clarified and extende

PAMELA, DAMA, INTEGRAL and Signatures of Metastable Excited WIMPs

Models of dark matter with ~ GeV scale force mediators provide attractive explanations of many high energy anomalies, including PAMELA, ATIC, and the WMAP haze. At the same time, by exploiting the ~ MeV scale excited states that are automatically present in such theories, these models naturally explain the DAMA/LIBRA and INTEGRAL signals through the inelastic dark matter (iDM) and exciting dark matter (XDM) scenarios, respectively. Interestingly, with only weak kinetic mixing to hypercharge to mediate decays, the lifetime of excited states with delta < 2 m_e is longer than the age of the universe. The fractional relic abundance of these excited states depends on the temperature of kinetic decoupling, but can be appreciable. There could easily be other mechanisms for rapid decay, but the consequences of such long-lived states are intriguing. We find that CDMS constrains the fractional relic population of ~100 keV states to be <~ 10^-2, for a 1 TeV WIMP with sigma_n = 10^-40 cm^2. Upcoming searches at CDMS, as well as xenon, silicon, and argon targets, can push this limit significantly lower. We also consider the possibility that the DAMA excitation occurs from a metastable state into the XDM state, which decays via e+e- emission, which allows lighter states to explain the INTEGRAL signal due to the small kinetic energies required. Such models yield dramatic signals from down-scattering, with spectra peaking at high energies, sometimes as high as ~1 MeV, well outside the usual search windows. Such signals would be visible at future Ar and Si experiments, and may be visible at Ge and Xe experiments. We also consider other XDM models involving ~ 500 keV metastable states, and find they can allow lighter WIMPs to explain INTEGRAL as well.Comment: 22 pages, 7 figure

Transformation kinetics of alloys under non-isothermal conditions

The overall solid-to-solid phase transformation kinetics under non-isothermal conditions has been modeled by means of a differential equation method. The method requires provisions for expressions of the fraction of the transformed phase in equilibrium condition and the relaxation time for transition as functions of temperature. The thermal history is an input to the model. We have used the method to calculate the time/temperature variation of the volume fraction of the favored phase in the alpha-to-beta transition in a zirconium alloy under heating and cooling, in agreement with experimental results. We also present a formulation that accounts for both additive and non-additive phase transformation processes. Moreover, a method based on the concept of path integral, which considers all the possible paths in thermal histories to reach the final state, is suggested.Comment: 16 pages, 7 figures. To appear in Modelling Simul. Mater. Sci. En

Singlet Portal to the Hidden Sector

Ultraviolet physics typically induces a kinetic mixing between gauge singlets which is marginal and hence non-decoupling in the infrared. In singlet extensions of the minimal supersymmetric standard model, e.g. the next-to-minimal supersymmetric standard model, this furnishes a well motivated and distinctive portal connecting the visible sector to any hidden sector which contains a singlet chiral superfield. In the presence of singlet kinetic mixing, the hidden sector automatically acquires a light mass scale in the range 0.1 - 100 GeV induced by electroweak symmetry breaking. In theories with R-parity conservation, superparticles produced at the LHC invariably cascade decay into hidden sector particles. Since the hidden sector singlet couples to the visible sector via the Higgs sector, these cascades necessarily produce a Higgs boson in an order 0.01 - 1 fraction of events. Furthermore, supersymmetric cascades typically produce highly boosted, low-mass hidden sector singlets decaying visibly, albeit with displacement, into the heaviest standard model particles which are kinematically accessible. We study experimental constraints on this broad class of theories, as well as the role of singlet kinetic mixing in direct detection of hidden sector dark matter. We also present related theories in which a hidden sector singlet interacts with the visible sector through kinetic mixing with right-handed neutrinos.Comment: 12 pages, 5 figure

Decaying into the Hidden Sector

The existence of light hidden sectors is an exciting possibility that may be tested in the near future. If DM is allowed to decay into such a hidden sector through GUT suppressed operators, it can accommodate the recent cosmic ray observations without over-producing antiprotons or interfering with the attractive features of the thermal WIMP. Models of this kind are simple to construct, generic and evade all astrophysical bounds. We provide tools for constructing such models and present several distinct examples. The light hidden spectrum and DM couplings can be probed in the near future, by measuring astrophysical photon and neutrino fluxes. These indirect signatures are complimentary to the direct production signals, such as lepton jets, predicted by these models.Comment: 40 pages, 5 figure

Conservative Constraints on Dark Matter from the Fermi-LAT Isotropic Diffuse Gamma-Ray Background Spectrum

We examine the constraints on final state radiation from Weakly Interacting Massive Particle (WIMP) dark matter candidates annihilating into various standard model final states, as imposed by the measurement of the isotropic diffuse gamma-ray background by the Large Area Telescope aboard the Fermi Gamma-Ray Space Telescope. The expected isotropic diffuse signal from dark matter annihilation has contributions from the local Milky Way (MW) as well as from extragalactic dark matter. The signal from the MW is very insensitive to the adopted dark matter profile of the halos, and dominates the signal from extragalactic halos, which is sensitive to the low mass cut-off of the halo mass function. We adopt a conservative model for both the low halo mass survival cut-off and the substructure boost factor of the Galactic and extragalactic components, and only consider the primary final state radiation. This provides robust constraints which reach the thermal production cross-section for low mass WIMPs annihilating into hadronic modes. We also reanalyze limits from HESS observations of the Galactic Ridge region using a conservative model for the dark matter halo profile. When combined with the HESS constraint, the isotropic diffuse spectrum rules out all interpretations of the PAMELA positron excess based on dark matter annihilation into two lepton final states. Annihilation into four leptons through new intermediate states, although constrained by the data, is not excluded.Comment: 11 pages, 5 figures. v3: minor revisions, matches version to appear in JCA