Patient-Controlled Analgesia (PCA) in Acute Pain: Pharmacological and Clinical Aspects

Moderate or severe pain are important sources of complications as well as morbidity and mortality in the postoperative period after surgical procedures. Patient‐controlled analgesia (PCA) is an effective strategy for postoperative analgesia, since it may provide suitable analgesic dose just after system activation, with reduced periods of pain and an increase in patients’ satisfaction. Although intravenous and epidural routes are the typical approaches used for PCA, regional patient‐controlled analgesia has been shown to be an effective alternative providing a higher standard of analgesia with lower incidence of adverse effects. New devices and routes of PCA administration (transdermal, sublingual, inhalation, and oral routes) have shown to be promising alternatives in clinical studies. Nowadays, there is still no consensus regarding which is the best route or drug used since clinical efficacy/safety depends on the complex comprehension of the drugs pharmacokinetic profile through different routes of administration. Additionally, pharmacoeconomic studies are needed to evaluate the cost‐effectiveness of these approaches

Avaliação da funcionalidade de idosos com osteoartrite utilizando o Lower Extremity Functional Scale (LEFS)

Introdução: A osteoartrite é uma doença crônico-degenerativa muito prevalente em idosos, a qual desencadeia limitações funcionais e pior qualidade de vida. Embora existam questionários para avaliação da funcionalidade destes pacientes, a busca por instrumentos específi cos para avaliação de membros inferiores apresenta relevância na prática fi sioterapêutica. Objetivos: Avaliar a correlação do Lower Extremity Functional Scale (LEFS) com a funcionalidade e componentes físicos e mentais da qualidade de vida em idosos com osteoartrite. Método: Estudo transversal, no qual a funcionalidade foi avaliada pelos questionários WOMAC, Lequesne e LEFS e a qualidade de vida foi avaliada pelo questionário SF-36. Resultados: Participaram do estudo 105 idosos (Idade: 68,80± 6,3 anos) com osteoartrite de joelho ou quadril, sendo 31homens e 74 mulheres. Não foi observada associação entre a idade (p>0,05) e o comprometimento funcional avaliado tanto pelo índice WOMAC quanto Lequesne (p>0,05) na população estudada. Foi observada correlação negativa entre o indice WOMAC e o LEFS (rS=-0,81) e o Lequesne e o LEFS (rS=-0,86). Além disso, foi verifi cada associação entre os escores do LEFS e a capacidade funcional (rS=0,80), limitação por aspectos físicos (rS=0,44), dor (rS=0,55) e estado geral de saúde (rS=0,44). Ainda, foi verifi cada correlação entre o escore do LEFS e a vitalidade (rS=0,60), aspectos sociais (rS=0,38), limitação por aspectos emocionais (rS=0,38) e saúde mental (rS=0,41). Conclusão: Concluise que o LEFS apresenta boa correlação com os índices WOMAC e Lequesne e com os componentes físicos e mentais da qualidade de vida, podendo constituir um instrumento clínico para avaliação do impacto funcional da osteoartrite em idosos. Introduction: Osteoarthritis is a chronic degenerative disease very prevalent in the elderly, which triggers functional limitations and poorer quality of life. Although there are already established instruments to evaluate the functional status of these patients, the search for specific instruments for assessment of lower limbs has relevance in physical therapy practice. Objective: This study aimed to evaluate the correlation between LEFS with functional status and physical and mental components of quality of life of older adults with osteoarthritis. Methods: At this cross-sectional study, the functional status was assessed by WOMAC, Lequesne and LEFS indexes and the quality of life was assessed by SF-36. Results: This study included 105 elderly (age: 68.80 ± 6.3 years) with osteoarthritis of the knee or hip, being 31 men and 74 women. It was not observed a correlation between age and functional status (p>0.05) analyzed by WOMAC and Lequesne indexes. However, negative correlations between WOMAC and LEFS(rS=- 0.81) as well as Lequesne and LEFS(rS= -0.86) were observed according to Spearman’s correlation. Moreover, there was a correlation between the LEFS’ score and functional capacity (rS = 0.80), limitation by physical aspects (rS= 0.44), pain (rS= 0.55) and general health (rS = 0.44). Moreover, it was also observed a positive correlation between the LEFS’ score and vitality (rS=0.60), social status (rS= 0.38), limitation for emotional aspects (rS=0.38) and mental health (rS= 0.41). Conclusion: LEFS correlates well with the WOMAC and Lequesne indexes as well as the physical and mental components of quality of life and it may be an alternative clinical tool for assessing the functional impact of osteoarthritis in the elderly