Microvessel density relation to HIF1α expression and local disease relapse in operated and irradiated patients.

<p>Microvessel density relation to HIF1α expression and local disease relapse in operated and irradiated patients.</p

HIF1α expression association with the status alive or local disease relapse.

<p>HIF1α expression association with the status alive or local disease relapse.</p

HIF1α expression and specific or local disease-free survival after treatment.

<p>Considering surgical (S) treatment only, high HIF1α expression predicts local disease-free survival. Considering surgery plus radiotherapy (S+RT), high HIF1α expression predicts both specific and local disease-free survival.</p

Correlation of tumor epidemiological and pathological features with HIF1α expression.

*<p>TNM classification (3^rd edition).</p

Local disease-free survival relation to HIF1α expression.

<p>High HIF1α expression is related to an increased local disease-free survival.</p

Epidemiological features.

<p>Epidemiological features.</p

Survival plots.

<p><b>a. and b.:</b> Disease-free survival and disease-specific survival according to FAS expression; <b>c. and d.:</b> Disease-free survival and disease-specific survival according to FASL expression.</p

Multivariate analysis of the relationship between clinical, pathological tumor features and survival with FAS and FASL expression.

<p>OR – Odds ratio; HR – Hazard ratio; CI – Confidence interval.</p>¥<p>Values adjusted by multivariate logistic regression.</p>§<p>Values adjusted by Cox proportional hazards.</p

Survival plots.

<p><b>a. and b.:</b> Disease-free survival and disease-specific survival according to FAS/FASL profile.</p

Epidemiological, clinical and pathological tumor features and their association with FAS and FASL expression.

¥<p>TNM classification 3^rd edition.</p>*<p>Not available (not considered in the statistical calculations).</p