Unemployment as a social cost

Over the last decade, workfare programmes provided support to the unemployed only insofar as they were willing to accept a job. The theoretical underpinnings of these programmes are that institutional constraints prevent labour supply from adjusting to the technologically determined requirements of labour demand. We contend that when individuals look for a job, they generally want to take into account non-monetary features such as occupational status. Status cannot be traded, it usually is complementary to income, it determines lifestyles and life possibilities. As for labour demand, its requirements do not reflect efficient behaviour and technical constraints because business ”efficiency” cannot be taken to be a measure of social efficiency and technology cannot be used as a benchmark to assess the efficiency of business conduct. We suggest that Sen’s notion of capabilities may constitute an appropriate benchmark to assess the social efficiency of the economic system. This leads us to a few policy implications. The ”capabilities benchmark” leads us to stress the importance of freedom to choose how to conduct one’s life. Acting in favour of freedom involves the understanding of how business strategies affect learning patterns and available choice sets. It also involves the assessment of policy issues - such as cooperation between the scientific community and business, scientific freedom, educational goals and their institutional implementation, and unemployment relief systems - which may influence the relation between business strategies and social learning.

Financialization and Deindustrialization in the Southern European Periphery

Historically, Southern European countries have shared a \u2018semi-peripheral\u2019 model of capitalism which has been characterized by fundamental fragilities in the production system. The financialization induced by the EMU has rendered these economies more fragile and unstable. Liberalization and market reform policies have taken southern economies onto the path of a credit-based and passively-extroverted financialized economy that trap them into a low-cost-of-wages search of competitiveness. However, the lack of autonomy in macroeconomic policies has weakened Southern opportunity to react to the financial crisis. The \u2018internal devaluation\u2019 policies that followed have caused a deep and thorough process of de-industrialization. This has sped-up the centralization of the European economy that has its centre in a narrow space within Paris, Amsterdam, Berlin and Frankfurt

Conserved molecular interactions in centriole-to-centrosome conversion.

Centrioles are required to assemble centrosomes for cell division and cilia for motility and signalling. New centrioles assemble perpendicularly to pre-existing ones in G1-S and elongate throughout S and G2. Fully elongated daughter centrioles are converted into centrosomes during mitosis to be able to duplicate and organize pericentriolar material in the next cell cycle. Here we show that centriole-to-centrosome conversion requires sequential loading of Cep135, Ana1 (Cep295) and Asterless (Cep152) onto daughter centrioles during mitotic progression in both Drosophila melanogaster and human. This generates a molecular network spanning from the inner- to outermost parts of the centriole. Ana1 forms a molecular strut within the network, and its essential role can be substituted by an engineered fragment providing an alternative linkage between Asterless and Cep135. This conserved architectural framework is essential for loading Asterless or Cep152, the partner of the master regulator of centriole duplication, Plk4. Our study thus uncovers the molecular basis for centriole-to-centrosome conversion that renders daughter centrioles competent for motherhood.J.F., Z.L., S.S. and N.S.D. are supported from Programme Grant to D.M.G. from Cancer Research UK. H.R. is supported from MRC Programme Grant to D.M.G. J.F. thank the British Academy and the Royal Society for Newton International Fellowship and Z.L. thanks the Federation of European Biochemical Societies for the Long-Term postdoctoral Fellowship. The authors thank Nicola Lawrence and Alex Sossick for assistance with 3D-SIM.This is the author accepted manuscript. The final version is available from NPG via http://dx.doi.org/10.1038/ncb327

Abstract vs. Practical Knowledge and Economic Policy. An Institutional Perspective

The paper compares the conventional economic approach with institutional economics as proposed by Karl Polany and William Kapp. The argument is that the two aproaches rely on different types of knowledge: abstract and universal principles, the former; based on practical guidelines and contextual facts, the latter. Even the representation of agents differ: an \u201cimage\u201d of the agent is needed in conventional economics, whose behaviour is consistent with the rest of the formal model; institutional economcis instead can deal with real social actors who are built in the process. Such differences become crucial when the aim of economics comes at stake; both approaches have a strong policy orientation (see Varian 1997 and Kapp 1976 as references), but the paper argues that an abstract knowledge is not suited to economics as a practical science in aristotelic terms \u2013 which include locally sound principles of action