Changes in lung function in subjects developing HAPE and in healthy controls.

<p>FVC (upper panel), closing volume above RV (middle panel) and DLCO adjusted for PIO₂ (lower panel), all expressed in percent of the value at 490 m. HAPE  =  subjects subsequently developing HAPE, controls  =  subjects not developing HAPE; first and last day at 4559 m  =  values measured on the day of arrival and either on the last day before clinically overt HAPE occurred, or on day 3 in controls. *P<0.05 vs. 490 m. **P<0.05 vs. controls.</p

Subjects characteristics.

<p>Values are presented as mean (SD), *P<0.05 vs. controls.</p

Pulmonary function and arterial blood gas analysis.

<p>Means ±SD. FVC, FEV1, PEF: forced expiratory vital capacity, expiratory volume in 1 sec and peak expiratory flow, respectively; CV: closing volume above residual volume. TLC, RV: total lung capacity and residual volume measured by methane dilution; SNIP: sniff nasal inspiratory pressure; DLCO: carbon monoxide single-breath diffusing capacity in absolute units, in % predicted and in % predicted after adjustment for reduced PIO₂.</p>*<p>P<0.05 vs. 490 m within group.</p>¶<p>P<0.05 vs. controls.</p>#<p>P = 0.05 vs. controls.</p

Nocturnal polygraphic monitoring.

<p>Means±SD; 490 m refers to the baseline examinations in Zurich performed in HAPE susceptibles exclusively; night 1 corresponds to the 1^st measurement, last night to the last measurement before overt HAPE occurred in the HAPE group and to the measurement in the 2^nd night at 4559 m in controls respectively.</p>*<p>P<0.05 vs. 490 m within group.</p>¶<p>P<0.05 vs. controls.</p

Additional file 1: Figure S1. of Effect of diagnosis related groups implementation on the intensive care unit of a Swiss tertiary hospital: a cohort study

Patient inclusion flow chart. Figure S2. Linear regression analysis based on forecasts with Newey-West standard errors (Lag 1). Table S1. DRG reduces the number of external admission in patients with low severity of disease. Table S2. The number of in-patients and external admissions with a high clinical severity increased significantly from 2009 to 2012, whereas admissions of in-patients with a low severity decreased. Table S3. Clinical severity of disease (SAPS II) at admission and LOS was weakly but positively corre-lated. Table S4. SAPS II and ICU LOS correlated positively in survivors, negatively in patients not surviving ICU. (PDF 1326 kb

Additional file 1 of Subjective and objective survival prediction in mechanically ventilated critically ill patients: a prospective cohort study

Additional file 1. Online data supplement

Summary of total number, total area of retinal hemorrhages (in optic disc areas) and percentage of climbers with hemorrhages per group at different altitudes.

<p>Summary of total number, total area of retinal hemorrhages (in optic disc areas) and percentage of climbers with hemorrhages per group at different altitudes.</p

Results of multiple regression analysis performed with total number and total area of hemorrhages and various independent predictors.

<p>Results of multiple regression analysis performed with total number and total area of hemorrhages and various independent predictors.</p

Fundus photographs of a climber from group 1 showing the development of retinal hemorrhages during the course of her climb.

<p>Note the white-centered hemorrhage localized at the temporal inferior branch of the retinal artery.</p

Graphs describing hemorrhages in both groups of climbers at different altitudes.

<p>Panel A: total number of hemorrhages; panel B: total area of hemorrhages; panel C: percentage of mountaineers with hemorrhages in at least 1 eye.</p