Structure predictions for SELO proteins.

<p>Assignments of human SELO protein (gi: 172045770), to PDB, SCOP and Pfam using FFAS and HHpred methods. Top hits shown for each combination of method, query protein, and database. For Scop hits, d.144 denotes members of Protein kinase-like (PK-like) fold. Prediction for other SELO proteins are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032138#pone.0032138.s006" target="_blank">Table S1</a>.</p

CLANS graph visualizing PSI-BLAST-detected significant (dark grey) and sub-significant (light grey) similarities among protein kinase-like proteins.

<p>Red: UPF0061 (SELO) family, Light green: pkinase and pkinase_Tyr, Dark blue: APH phosphotransferase, Magenta: PIP5K, Grey: alpha_kinase. Pink: PI3_PI4, Light blue: Act_Frag_cataly, Yellow: PPDK_N, Dark green: Kdo, Orange: UL97.</p

Active site details in the model of the kinase domain of the human SELO protein.

<p><i>Top</i>. Schematic representation. Comparison of binding of an ATP molecule and two Mg²⁺ ions in SELO model (upper residue labels) and in the PKA structure (lower labels). <i>Bottom</i>. As in top panel, wireframe model of the predicted active site of human SELO with ATP and two Mg²⁺ ions.</p

Counts of erythrocyte proteins in phylogenetic clusters mapped onto taxonomic classification.

<p>The classification has been shown up to a division/phylum level, except for Metazoa which have been expanded to show differences between different classes of animals (expanded to the equal level of depth) and Proteobacteria which have been expanded to include its classes. Red: cluster A, dark blue: cluster B, light blue: cluster C, yellow: cluster D, magenta: cluster E, green: cluster F, brown: cluster G, grey: unclustered cloud. Counts are normalized against cluster size.</p

Venn diagram of species counts for the four largest (in terms of the number of HRBC proteins) clusters.

<p>Venn diagram of species counts for the four largest (in terms of the number of HRBC proteins) clusters.</p

Phylogenetic clustering of erythrocyte proteins.

<p>Red: cluster A, dark blue: cluster B, light blue: cluster C, yellow: cluster D, magenta: cluster E, green: cluster F, brown: cluster G, grey: unclustered cloud. Plot in log scale.</p

Protein length versus number of taxonomy hits, by cluster.

<p>Red: cluster A, dark blue: cluster B, light blue: cluster C, yellow: cluster D, magenta: cluster E, green: cluster F, brown: cluster G, grey: unclustered cloud.</p

Protein length versus no of taxonomy hits.

<p>Left pane – disease mutation proteins. Right pane – other proteins. Red: cluster A, dark blue: cluster B, light blue: cluster C, yellow: cluster D, magenta: cluster E, green: cluster F, brown: cluster G, grey: unclustered cloud. Plot in log scale.</p

Functional families (COGs) overrepresented in genomic neighbourhoods of microbial SELO homologues.

<p>Statistical analysis using 22-kbp wide genomic windows.</p

Summary data for obtained clusters.

<p>Summary data for obtained clusters.</p