Treatment of Medication-Related Osteonecrosis of the Jaw and its Impact on a Patient\ue2\u80\u99s Quality of Life: A Single-Center, 10-Year Experience from Southern Italy

Introduction: No official guidelines are available for the management of medication-related osteonecrosis of the jaw (MR-ONJ). The additional benefit of surgery after pharmacological treatment is debated by both clinicians and patients. Objective: The aim of this study was to evaluate the changes in patients\u2019 MR-ONJ-related quality of life (QoL) after pharmacological treatment with or without surgery in a large cohort affected by MR-ONJ. Methods: Anonymized data on patients diagnosed with MR-ONJ were extracted from the database of the Osteonecrosis of the Jaw Treatment Center (University of Messina, Italy) in the years 2005\u20132015. QoL was evaluated at the moment of MR-ONJ diagnoses (T0), after pharmacological treatment with or without surgery (T1 and T2, respectively), based on scores from the European Organisation for Research and Treatment of Cancer (EORTC) QOL Module for Head and Neck Cancer (global oral health status [GOHS]) and a visual analog scale (VAS), stratified by indication for use. Results: Among 100 patients, 36% were affected by osteoporosis (OSTEO group) and 64% were affected by cancer (ONC group). Considering T0, QoL scores were higher in the OSTEO group then in the ONC group. At T1, GOHS and VAS increased in both groups (OSTEO group: +9.9% and +39.9%; ONC group: +35.4 and +97.2%, respectively). Pharmacological treatment was effective in reducing pain (OSTEO group: 1222.0%; ONC group: 1244.8%), and social contact troubles (OSTEO group: 1240.3%; ONC group: 1226.7%). At T2, GOHS and VAS further increased. Scores related to \u2018pain\u2019 and the troubles related to the \u2018social dimension\u2019 also decreased (OSTEO group: 1291.3% and 1272.0%; ONC group: 50.8% and 1216.4%, respectively). Conclusions: MR-ONJ-related QoL increased after pharmacological treatment and, more notably, after surgery, which may offer benefits to selected patients. QoL data may help clinicians in promoting tailored management of MR-ONJ. \ua9 2017 Springer Internationa

Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Society of Oral Pathology and Medicine (SIPMO) Ancona, 20 October 2018 - Part II

none22nononeCampisi, Giuseppina; Bedogni, Alberto; Bertoldo, Francesco; Bettini, Giordana; Biasotto, Matteo; Colella, Giuseppe; Consolo, Ugo; Di Fede, Olga; Favia, Gianfranco; Fusco, Vittorio; Gabriele, Mario; Lo Casto, Antonio; Lo Russo, Lucio; Marcianò, Antonia; Mauceri, Rodolfo; Meleti, Marco; Mignogna, Michele; Oteri, Giacomo; Panzarella, Vera; Romeo, Umberto; Santarelli, Andrea; Vescovi, PaoloCampisi, Giuseppina; Bedogni, Alberto; Bertoldo, Francesco; Bettini, Giordana; Biasotto, Matteo; Colella, Giuseppe; Consolo, Ugo; Di Fede, Olga; Favia, Gianfranco; Fusco, Vittorio; Gabriele, Mario; Lo Casto, Antonio; Lo Russo, Lucio; Marcianò, Antonia; Mauceri, Rodolfo; Meleti, Marco; Mignogna, Michele; Oteri, Giacomo; Panzarella, Vera; Romeo, Umberto; Santarelli, Andrea; Vescovi, Paol