Demographics and D-dimer levels.

<p>(a) SMART/ESPRIT/SILCAAT; adjusted for demographics, HIV-specific variables and biomarkers of inflammation. (b) SMART/ESPRIT; as in (a) and also adjusted for co-morbidities (CVD, DM and hepatitis B/C) and eGFR. (c) SMART only; as in (b) and also adjusted for smoking, cystatin C and cholesterol levels.</p

Baseline Characteristics by Dataset ESPRIT, SILCAAT and SMART Patients.

<p>*Not ascertained for patients in SILCAAT.</p><p>**Not ascertained for patients in SILCAAT or ESPRIT.</p><p>***Data available for n = 245 participants.</p><p>****Data available for n = 860 participants.</p

Figure 2. D-dimer levels across age groups stratified by gender (a).

<p>(a) SMART/ESPRIT/SILCAAT; adjusted for demographics, HIV-specific variables and biomarkers of inflammation.</p

HIV-specific variables and D-dimer levels.

<p>(a) SMART/ESPRIT/SILCAAT (N = 9848; 821 of whom were off ART at baseline); adjusted for demographics, HIV-specific variables and biomarkers of inflammation. (b) SMART/ESPRIT (N = 6928); as in (a) and also adjusted for co-morbidities (CVD, DM and hepatitis B/C) and eGFR<b>.</b> (c) SMART (N = 4488); as in (b) and also adjusted for smoking, cystatin C and cholesterol levels.</p

Biomarkers of Inflammation and D-dimer levels.

<p>(a) SMART/ESPRIT/SILCAAT (N = 9848); adjusted for demographics, HIV-specific variables and biomarkers of inflammation<b>.</b> (b) SMART/ESPRIT (N = 6928); as in (a) and also adjusted for co-morbidities (CVD, DM and hepatitis B/C) and eGFR. (c) SMART (N = 4488); as in (b) and also adjusted for smoking, cystatin C and cholesterol levels.</p

Correlation between D-dimer and IL-6 levels*.

<p>* Plotted values refer to log₁₀ transformed levels of units of measurement based on the molecular masses of D-dimer and IL-6 (nmol/L for D-dimer and fmol/L for IL-6).</p

Outcomes through 14 days of follow-up for A(H1N1)pdm09-infected patients enrolled in FLU002.

<p>Outcomes through 14 days of follow-up for A(H1N1)pdm09-infected patients enrolled in FLU002.</p

Baseline characteristics associated with disease progression: FLU002 and FLU003 pooled.

<p>*Univariate odds ratio for disease progression. OR for age is for 10 years older.</p><p>**Multivariate model using imputed data with adjustment for all variables listed.</p><p>***P-value for linear trend from multivariate model = 0.16</p><p>****P-value for linear trend from multivariate model = 0.10</p

FLU 003 flow diagram.

<p>FLU 003 flow diagram.</p

Baseline characteristics associated with disease severity at entry: FLU002 versus FLU003.

<p>*Odds ratio for FLU003 vs. FLU002. OR for age is for 10 years older.</p><p>**Multivariate model using imputed data with adjustment for all variables listed except coinfections.</p><p>***P-value for linear trend from multivariate model = .0010</p><p>****P-value for linear trend from multivariate model = .0000</p><p>*****As above for a subset of patients (n = 333) analyzed for co-infections.</p