Analysis of polymorphisms according to prostate cancer aggressiveness and lethality.

<p>aOR = age-adjusted OR, number of controls = 656.</p><p>*MAF in controls = 0.46.</p><p>**not in HWE.</p><p>p-heterogeneity between aggressive and non-aggressive for rs10948059: CT vs CC = 0.06, TT vs CC = 0.09, per-allele = 0.09.</p

Frequency of GNMT polymorphisms and association with prostate cancer risk.

<p>aOR = age-adjusted OR.</p><p>*Minor allele frequency in controls = 0.456.</p><p>**not in HWE.</p

Haplotype frequencies and their association with prostate cancer risk (haplotype STRP1- rs10948059).

<p>*Only haplotypes with estimated frequencies >1% are listed.</p><p>**Estimated numbers of informative haplotypes: PCa cases = 1034, controls = 1003.</p

Characteristics of prostate cases (PCa) and controls.

<p>* 20 missing data on stage (3.0%).</p><p>** 31 missing data on Gleason score (4.7%).</p><p>*** 44 missing data on PSA at diagnosis (6.7%).</p

Frequency of the polymorphisms and association of the risk alleles with prostate cancer in Taiwanese prostate cancer study and HPFS controls.

<p>*Comparison of <i>GNMT</i> allelic and genotypic distributions between Taiwanese population and HPFS (chi-square test).</p

Characteristics of PLWHA with and without CMV End-organ Disease.

<p>Characteristics of PLWHA with and without CMV End-organ Disease.</p

Univariate and Multivariate Analyses of the Association of CMV End-organ Disease and All-cause Stroke among PLWHA.

<p>Univariate and Multivariate Analyses of the Association of CMV End-organ Disease and All-cause Stroke among PLWHA.</p

Molecular Epidemiology of HIV-1 Infection among Men who Have Sex with Men in Taiwan in 2012

<div><p>The number of men who have sex with men (MSM) infected with HIV-1 in Taiwan has increased rapidly in the past few years. The goal of this study was to conduct a molecular epidemiological study of HIV-1 infection among MSM in Taiwan to identify risk factors for intervention. Voluntary counseling program and anonymous testing were provided to patrons at 1 gay bar, 7 night clubs and 3 gay saunas in Taipei and New Taipei Cities in 2012. HIV-1 subtypes were determined using gag subtype-specific PCR and phylogenetic analysis by env sequences. Recent HIV-1 infection was determined using LAg-Avidity EIA. In-depth interviews and questionnaires were used to identify risk factors. The prevalence and incidence of HIV-1 among MSM in Taiwan were 4.38% (53/1,208) and 3.29 per 100 person-years, respectively. Of 49 cases genotyped, 48 (97.9%) were infected with subtype B and 1 with CRF01_AE (2%). Phylogenetic analysis of 46 HIV-1 strains showed that 25 (54.4%) subtype B strains formed 9 clusters with each other or with other local strains. The CRF01_AE case clustered with a reference strain from a Thai blood donor with bootstrap value of 99. Multivariate logistic regression analysis showed that risk factors associated with HIV-1 infection included use of oil-based solution as lubricant (vs. saliva or water-based lubricants, OR= 4.23; p <0.001); exclusively receptive role (vs. insertive role, OR= 9.69; p <0.001); versatile role (vs. insertive role, OR= 6.45; p= 0.003); oral sex (vs. insertive role, OR= 11.93; p= 0.044); times of sexual contact per week (2-3 vs. zero per week, OR= 3.41; p= 0.021); illegal drug use (OR= 4.12; p <0.001); and history of sexually transmitted diseases (OR= 3.65; p= 0.002). In conclusion, there was no new HIV-1 subtype or circulating recombinant form responsible for the increase of HIV-1 among MSM in Taiwan in 2012. Misuse of oil-based solution as lubricant is a new risk factor identified among MSM in Taiwan. The Taiwan’s Centers for Disease Control has created a video (<a href="http://www.youtube.com/watch?v=BinExvvOTMM&feature=iv&src_vid=BW81-PfmY3E&annotation_id=annotation_2436493705" target="_blank">www.youtube.com/watch?v=BinExvvOTMM&feature=iv&src_vid=BW81-PfmY3E&annotation_id=annotation_2436493705</a>) to correct such misconception in its AIDS prevention campaign.</p></div

Distribution of different types or numbers of illegal drugs used among MSM in Taiwan.

<p>RUSH = alkyl nitrites or poppers, MDMA = 3,4-methylenedioxy-N-methylamphetamine or ecstasy, LSD = Lysergic acid diethylamide, PCP = Phencyclidine</p><p>*, Chi-square test.</p><p>^§, Fisher exact test.</p><p>Distribution of different types or numbers of illegal drugs used among MSM in Taiwan.</p

Demographic data of patrons from different gay venues participated in this study.

<p>*, Chi-square test.</p><p>^§, Fisher exact test.</p><p>^†, Student T Test.</p><p>Demographic data of patrons from different gay venues participated in this study.</p