Mesenteric vascular reactivity.

<p>Effect of treatment with ASE (200mg/Kg/day) and exercise training (30 min/day; 5 days per week) on vasodilator effects of ACh (A) and NG (B), and vasoconstrictor effects of NE (C) in mesenteric arterial bed from type 2 diabetic rats. Data are mean ± SEM, n = 10 for all groups. *Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Controls; ⁺Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Sedentary D.</p

Expression of insulin cascade and pAMPK protein.

<p>Effect of treatment with ASE (200mg/Kg/day) and exercise training (30 min/day; 5 days per week) on IR (A), AKT (B), pAKT (C), GLUT-4 (D) and pAMPK expressions in skeletal muscle from type 2 diabetic rats. Data are mean ± SEM, n = 4 for all groups. Using one-way ANOVA: *Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Controls; ^●Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Training C; ⁺Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Sedentary D; ^$Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Training D; ^δSignificantly different (<i>p ≤ 0</i>.<i>05</i>) from ASE Sedentary D. Using unpaired Student's t-test: ^&Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Sedentary D.</p

Effects of ASE (200mg/Kg/day) and exercise training (30 min/day; 5 days per week) on glucagon-like peptide-1 (GLP-1), leptin, and anti-inflammatory cytokine serum levels in type 2 diabetic animals.

<p>Effects of ASE (200mg/Kg/day) and exercise training (30 min/day; 5 days per week) on glucagon-like peptide-1 (GLP-1), leptin, and anti-inflammatory cytokine serum levels in type 2 diabetic animals.</p

Glycemic levels and body weight.

<p>Effect of treatment with ASE (200mg/Kg/day) and exercise training (30 min/day; 5 days per week) on blood glucose levels (A) and body weight (B) in type 2 diabetic rats. Data are mean ± SEM, n = 10 for all groups. *Significantly different (p<0.05) from Controls; ⁺Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Sedentary D; ^$Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Training D; ^δSignificantly different (<i>p ≤ 0</i>.<i>05</i>) from ASE Sedentary D.</p

Insulin resistance and β-cell function.

<p>Effect of treatment with ASE (200mg/Kg/day) and exercise training (30 min/day; 5 days per week) on serum insulin levels (A), HOMA-IR (B) and HOMA-B (C) indexes in type 2 diabetic rats. Data are mean ± SEM, n = 6 for all groups. *Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Controls; ⁺Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Sedentary D. ^$Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Training D.</p

Effects of ASE (200mg/Kg/day) and exercise training (30 min/day; 5 days per week) on HbA1c serum levels and lipid profile in type 2 diabetic animals.

<p>Effects of ASE (200mg/Kg/day) and exercise training (30 min/day; 5 days per week) on HbA1c serum levels and lipid profile in type 2 diabetic animals.</p

Components of the insulin cascade and adiponectin expression.

<p>Effect of treatment with ASE (200mg/Kg/day) and exercise training (30 min/day; 5 days per week) on IR (A), AKT (B), pAKT (C), GLUT-4 (D) and adiponectin (E) expressions in adipose tissue from type 2 diabetic rats. Data are mean ± SEM, n = 4 for all groups. Using one-way ANOVA: *Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Controls; ⁺Significantly different (p<0.05) from Sedentary D; ^$Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Training D; ^δSignificantly different (<i>p ≤ 0</i>.<i>05</i>) from ASE Sedentary D. Using unpaired Student's t-test: ^&Significantly different (<i>p ≤ 0</i>.<i>05</i>) from Sedentary D.</p

Timeline of the experimental protocol.

<p>Schematic figure illustrating the timeline of the experimental protocol. The abbreviations of the figure include HF (high fat); BWT (body weight); GLU (glucose); STZ (streptozotocin); ASE (açaí seed extract); SR (serum); VAT (visceral adipose tissue); SM (skeletal muscle) and MAB (mesenteric arterial bed).</p