Effects of music and painting training on accuracy in the phonemic blending (a) and rhythm reproduction (b) tasks, before and after training.

<p>Error bars indicate the standard error of the mean. Values are z-score normalized.</p

Flow chart illustrating participants’ recruitment and experimental design.

<p>Flow chart illustrating participants’ recruitment and experimental design.</p

Scatter plot of the improvement in the rhythm reproduction task (accuracy After training—accuracy Before training) and the improvement in the Phonemic blending task (accuracy After training—accuracy Before training).

<p>The ellipse contains the non-outlying data. The grey line represents the best linear fit to the remaining data (Spearman skipped correlation, [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0138715#pone.0138715.ref047" target="_blank">47</a>]). The shadow represents the 95% bootstrap CI.</p

Summary of results before and after training in WISC III Subtests, Auditory attention test, Self Esteem Competence Scale and Musical tasks.

<p>The column “Larger effect of music training” reports whether or not there is a larger and significant improvement in the music training group compared to the painting group (p value<0.05), except in the Block design test wherein the improvement is larger for the Painting group (+). When this is not the case (ns, p>0.05), significant main effects of session are reported (* = p<0.05; ** = p<0.01; *** = p<0.001), pointing to an equal improvement of both groups. The standard deviation from the mean is reported in parenthesis.</p><p>Summary of results before and after training in WISC III Subtests, Auditory attention test, Self Esteem Competence Scale and Musical tasks.</p

Prognostic Role of Serum Antibody Immunity to p53 Oncogenic Protein in Ovarian Cancer: A Systematic Review and a Meta-Analysis

<div><p>Objective</p><p>Serum p53 autoantibodies (p53-AAbs) are the product of an endogenous immune response against p53 overexpression driven by the ovarian tumour. The p53-AAbs are detectable only in a subset of patients. To date, the evidence of an association between the presence of p53-AAbs and ovarian cancer outcomes has been poorly investigated.</p><p>Methods</p><p>A systematic literature search was performed to identify eligible studies investigating the association of serum p53-AAbs and overall survival (OS) and disease free survival (DFS). Associations between presence of serum p53-AAbs and baseline tumour characteristics were also evaluated. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CI) were computed to estimate the prognostic impact of serum p53-AAbs. Heterogeneity between studies was assessed.</p><p>Results</p><p>A total of 583 patients (7 studies) for OS and 356 patients (4 studies) for DFS were included in the meta-analysis. Presence of p53-AAbs was not associated to OS (pooled uni- multivariate HR = 1.09; 95% CI: 0.55–2.16), and a large heterogeneity was found. When only multivariate HRs were pooled together (4 studies), presence of p53-AAbs was significantly associated to a better OS (pooled HR = 0.57; 95% CI: 0.40–0.81), and no significant heterogeneity was observed. A reduced DFS was associated to p53-AAbs (pooled uni- multivariate HR = 1.37; 95% CI: 0.83–2.25), though not significantly and with a moderate heterogeneity.</p><p>Conclusions</p><p>The prognostic significance of serum p53-AAbs in ovarian cancer was diverging according to uni or multivariate models used. Since the results of this work were based on only few investigations, large prospective studies are needed to better define the role of antibody immunity against p53.</p></div

Adolescent Admissions to Emergency Departments for Self-Injurious Thoughts and Behaviors

<div><p>The objective of the present study was to describe the incidence and the characteristics of Self-Injurious Thoughts and Behaviors (SITBs), among adolescents aged 11–18 admitted, over a two year period, to all the Emergency Departments of a Region of North-eastern Italy through a comprehensive analysis of medical records. A two-step search was performed in the regional ED electronic database. First, we identified the cases that had been clearly diagnosed as SITBs by an Emergency Department physician. Secondly, suspect cases were detected through a keyword search of the database, and the medical records of these cases were hand screened to identify SITBs. The mean annual incidence rate of SITBs was 90 per 100,000 adolescents aged 11–18 years. Events were more frequent in females. Drug poisoning was the most frequently adopted method (54%). In 42% of cases a diagnosis of SITB was not explicitly reported by the physician. In 65% of cases adolescents were discharged within hours of admission. Only 9% of patients started a psychiatric assessment and treatment program during hospital stay. This research confirms the high incidence of SITBs among adolescents and highlights the difficulty in their proper diagnosis and management. Such difficulty is confirmed by the fact that only a few patients, even among those with a clear diagnosis, were sent for psychiatric assessment. Correct identification and management of SITB patients needs to be improved, since SITBs are an important public health problem in adolescence and one of the main risk factors for suicide.</p></div

SITB cases visited in the EDs (n = 135): frequency and percentage of different methods used, including thoughts.

<p>SITB cases visited in the EDs (n = 135): frequency and percentage of different methods used, including thoughts.</p

Summary of clinical-pathological parameters of patients in the studies presenting multivariate HRs included in the meta-analysis.

<p>p53-AAbs: p53 autoantibodies; FIGO: International Federation of Gynaecology and Obstetrics; PLT: Platinum; CT: Chemotherapy; NA: Not Available; G3: poorly differentiated</p><p>*% is not related to the total of patients [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0140351#pone.0140351.ref025" target="_blank">25</a>].</p><p>Summary of clinical-pathological parameters of patients in the studies presenting multivariate HRs included in the meta-analysis.</p

Publication bias assessment of the studies assessing p53-AAbs presence and OS in ovarian cancer.

<p>(<b>A</b>) Funnel plot for publication bias assessment of pooled OS; (<b>B</b>) Egger’s linear regression test.</p

Seasonality of SITBs by sex among the cases visited in the EDs in the years 2005 and 2006: cases and, in parenthesis, incidence per 100,000.

<p>Seasonality of SITBs by sex among the cases visited in the EDs in the years 2005 and 2006: cases and, in parenthesis, incidence per 100,000.</p