Number of ILI patients positive for influenza A(H3N2) and negative for any influenza by week of symptom onset, hospital based study, and week of peak of influenza activities (pointed by the arrow) in the region.

<p>By study site, 2011–12.</p

Number of ILI patients positive for influenza A(H3N2) (N = 375) and negative for any influenza (N = 770) by week of symptom onset, hospital based IVE studies, EU – 2011–12.

<p>Number of ILI patients positive for influenza A(H3N2) (N = 375) and negative for any influenza (N = 770) by week of symptom onset, hospital based IVE studies, EU – 2011–12.</p

Participating services, screening procedure and number of patients screened and included per study site, hospital based Influenza VE study, EU, 2011–12.

*<p>Based on weekly average number of patients admitted with respiratory syndromes.</p

Characteristics of A(H3N2) influenza cases (N = 375) and test-negative controls (N = 770) swabbed less than five days after ILI symptoms onset included in the study, hospital based Influenza VE study, EU, 2011–12.

*<p>N = 814 (one record with missing information).</p>‡<p>Two-sided Fisher’s exact test.</p

Additional file 1: of Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Table S1. List of selected SNPs, Table S2. Relationship among reproductive factors and breast cancer stratifying by rs2229712 genotype; odds ratios adjusted for propensity score, menopausal status and the remaining variables in the table, Table S3. Relationship among reproductive factors and breast cancer stratifying by rs1269851 genotype; odds ratios adjusted for propensity score, menopausal status and the remaining variables in the table, Table S4. Relationship between reproductive factors and breast cancer stratified by rs2026001 genotype; odds ratios adjusted for propensity score, menopausal status and the remaining variables in the table, Table S5. Relationship between reproductive factors and breast cancer stratified by rs35652107 genotype; odds ratios adjusted for propensity score, menopausal status and the remaining variables in the table, Table S6. Relationship between reproductive factors and breast cancer stratified by rs6018027 genotype; odds ratios adjusted for propensity score, menopausal status and the remaining variables in the table, Table S7. Distribution of the genetic score, Table S8. List of pathways which the analyzed genes are involved in. (DOCX 43 kb

Additional file 2: Table S2. of The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis

Associations between polymorphisms and the Mediterranean Diet Pattern of Sofi considering different genetic models. Genetic models: codominant, dominant, recessive, overdominant, log-additive. (DOCX 16 kb

Additional file 1: Table S1. of The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis

Analysis of SNPs related to CRC. The minimally adjusted odds ratio (OR) was computed adjusting by sex, age, educational level. Area, places where cases and controls were recruited, was used as random variable. Association is evaluated for carrying 1 or 2 SNP minor frequency alleles relative to a reference of zero SNP minor frequency allele. (DOCX 22 kb

Additional file 2: Table S2. of Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study

Relationship between NSAID consumption and breast cancer according to COX2/COX1 selectivity and tumor characteristics (DOC 39 kb

Relationship between antihypertensive drug consumption and breast cancer according to women’s characteristics.

<p>Category reference no antihypertensive treatment.</p

Relationship between antihypertensive drug consumption and breast cancer according to tumor characteristic.

<p>Category reference: no antihypertensive treatment.</p