Directed Ising type dynamic preroughening transition in one dimensional interfaces

We present a realization of directed Ising (DI) type dynamic absorbing state phase transitions in the context of one-dimensional interfaces, such as the relaxation of a step on a vicinal surface. Under the restriction that particle deposition and evaporation can only take place near existing kinks, the interface relaxes into one of three steady states: rough, perfectly ordered flat (OF) without kinks, or disordered flat (DOF) with randomly placed kinks but in perfect up-down alternating order. A DI type dynamic preroughening transition takes place between the OF and DOF phases. At this critical point the asymptotic time evolution is controlled not only by the DI exponents but also by the initial condition. Information about the correlations in the initial state persists and changes the critical exponents.Comment: 12 pages, 10 figure

BALL - biochemical algorithms library 1.3

<p>Abstract</p> <p>Background</p> <p>The Biochemical Algorithms Library (BALL) is a comprehensive rapid application development framework for structural bioinformatics. It provides an extensive C++ class library of data structures and algorithms for molecular modeling and structural bioinformatics. Using BALL as a programming toolbox does not only allow to greatly reduce application development times but also helps in ensuring stability and correctness by avoiding the error-prone reimplementation of complex algorithms and replacing them with calls into the library that has been well-tested by a large number of developers. In the ten years since its original publication, BALL has seen a substantial increase in functionality and numerous other improvements.</p> <p>Results</p> <p>Here, we discuss BALL's current functionality and highlight the key additions and improvements: support for additional file formats, molecular edit-functionality, new molecular mechanics force fields, novel energy minimization techniques, docking algorithms, and support for cheminformatics.</p> <p>Conclusions</p> <p>BALL is available for all major operating systems, including Linux, Windows, and MacOS X. It is available free of charge under the Lesser GNU Public License (LPGL). Parts of the code are distributed under the GNU Public License (GPL). BALL is available as source code and binary packages from the project web site at <url>http://www.ball-project.org</url>. Recently, it has been accepted into the debian project; integration into further distributions is currently pursued.</p

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD–abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions

Histologie myocardique dans la stenose pulmonaire

CNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Angioplastie coronaire élective chez l'octogénaire

De juillet 1991 à novembre 2000, 66 patients, âgés de 80 ans et plus ont bénéficié d'une angioplastie coronaire. 68% avaient un angor instable, 2% un angor stable, 21% un infarctus et 9% une décompensation cardiaque aiguë. Les facteurs de risque étaient : diabète (21%), insuffisance rénale (4%), insuffisance respiratoire (3%). 33% des patients étaient mono-tronculaires, 40% bi-tronculaires et 25% tri-tronculaires dont 3% avaient une sténose du tronc commun. Les lésions étaient complexes dans 50% des cas. La fraction d'éjection était de 59,9 +- 16,2%. 111 sténoses ont été dilatées. Le taux de succès primaire était de 91% avec une revascularisation complète dans 50% des cas. La mortalité hospitalière était de 1,5%. Les complications étaient : insuffisance rénale (3%), hématome fémoral drainé chirurgicalement (3%). Il n'y a eu ni pontage en urgence, ni accident vasculaire cérébral, ni complication infectieuse, ni transfusion. Le suivi était complet et d'une durée de 0,6 à 6,7 ans. La survie actuarielle était de 93,3% à 1 an et 75% à 3 ans. Tous les patients étaient asymptomatiques au cours du suivi. Conclusion : chez l'octogénaire, l'angioplastie dont l'indication essentielle est l'angor instable, peut être réalisée avec un bon taux de succès immédiat et une mortalité très basse. Il est donc raisonnable d'en faire bénéficier les patients instables âgés de plus de 80 ansPARIS12-CRETEIL BU Médecine (940282101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Evaluation d'un nouvel outil diagnostique et d'une approche thérapeutique innovante dans l'atteinte cardiaque au cours des myopathies

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF

Evaluation d'un nouvel outil diagnostique et d'une approche thérapeutique innovante dans l'atteinte cardiaque au cours des myopathies

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF