A: Immunohistochemical doublestaining of a renal allograft specimen with Granzyme B (red) and CD57 (blue), illustrating a Granzyme B positive NK cell.

<p>Bar = 10 µm. B: Doublestaining of Granzyme B (red) with CD68 (blue). Note that macrophages do not express Granzyme B. Bar = 25 µm.</p

Absolute and relative numbers of CD3⁺ T cells (A), CD8⁺ T cells (B), FOXP3⁺ T cells (C and E) and Granzyme B⁺ T cells (D and F) in the intima of native atherosclerotic plaques (NA) and the intima of vessels with allograft vasculopathy (AV).

<p>*: P<0.05, ** P<0.005.</p

Demographical and histopathological characteristics of the patients and nephrectomy specimens.

<p>*not interpretable: no renal cortex present in the available tissue blocks to determine Banff score;</p><p>**: C4d not interpretable because of extensive haemorrhage.</p