5 research outputs found
Lung histology scores.
<p>Median (interquartile ranges); <i>*</i> = 40 vs 80, 40 vs 120, 40 vs 160; n.s.  =  not significant.</p
Markers of lung injury.
<p>The wet-dry weight ratio of the right lung (A). PaO<sub>2</sub> across time (B). Median and interquartile ranges are shown. *p<0.001 (ANOVA); **p<0.01 (repeated measures ANOVA on ranks).</p
Blood gases, respiratory mechanics and intracranial pressure.
<p>Median (interquartile ranges); Paw = mean airway pressure, PIP = peak inspiratory pressure, ICP = intracranial pressure.</p><p>* = p<0.001: 40 vs 80 vs 120 vs 160; ** = p<0.05: 40 vs 80, 80 vs 120; p<0.005: 40 vs 120, 40 vs 160; <sup>†</sup> = p<0.001: 40 vs 80, 40 vs 120; p<0.05: 40 vs 160, 120 vs 160; <sup>‡</sup> = p<0.01: 40 vs. 80, 40 vs 120, 40 vs 160; n.s.  =  not significant.</p
Bronchoalveolar lavage (BAL).
<p>Cell count (A) and differential cell count (B) were measured in the bronchoalveolar lavage fluid prior to intervention (initial BAL) and at the end of the experiment (final BAL). Data are averaged for the initial BAL and specified for the final BAL for group 40, group 80, group 120 and group 160. Median and interquartile ranges are shown. * = p<0.05 (ANOVA on ranks).</p
Table_3_Successful Resuscitation in a Model of Asphyxia and Hemorrhage to Test Different Volume Resuscitation Strategies. A Study in Newborn Piglets After Transition.pdf
<p>Background: Evidence for recommendations on the use of volume expansion during cardiopulmonary resuscitation in newborn infants is limited.</p><p>Objectives: To develop a newborn piglet model with asphyxia, hemorrhage, and cardiac arrest to test different volume resuscitation on return of spontaneous circulation (ROSC). We hypothesized that immediate red cell transfusion reduces time to ROSC as compared to the use of an isotonic crystalloid fluid.</p><p>Methods: Forty-four anaesthetized and intubated newborn piglets [age 32 h (12–44 h), weight 1,220 g (1,060–1,495g), Median (IQR)] were exposed to hypoxia and blood loss until asystole occurred. At this point they were randomized into two groups: (1) Crystalloid group: receiving isotonic sodium chloride (n = 22). (2) Early transfusion group: receiving blood transfusion (n = 22). In all other ways the piglets were resuscitated according to ILCOR 2015 guidelines [including respiratory support, chest compressions (CC) and epinephrine use]. One hour after ROSC piglets from the crystalloid group were randomized in two sub-groups: late blood transfusion and infusion of isotonic sodium chloride to investigate the effects of a late transfusion on hemodynamic parameters.</p><p>Results: All animals achieved ROSC. Comparing the crystalloid to early blood transfusion group blood loss was 30.7 ml/kg (22.3–39.6 ml/kg) vs. 34.6 ml/kg (25.2–44.7 ml/kg), Median (IQR). Eleven subjects did not receive volume expansion as ROSC occurred rapidly. Thirty-three animals received volume expansion (16 vs. 17 in the crystalloid vs. early transfusion group). 14.1% vs. 10.5% of previously extracted blood volume in the crystalloid vs. early transfusion group was infused before ROSC. There was no significant difference in time to ROSC between groups [crystalloid group: 164 s (129–198 s), early transfusion group: 163 s (162–199 s), Median (IQR)] with no difference in epinephrine use.</p><p>Conclusions: Early blood transfusion compared to crystalloid did not reduce time to ROSC, although our model included only a moderate degree of hemorrhage and ROSC occurred early in 11 subjects before any volume resuscitation occurred.</p