The results of the one-way sensitivity analysis.

<p>Incremental Cost-Effectiveness ratios (ICER) are expressed in Euros per QALY gained (€/Q).</p><p>(€1 =  $US 1.30).</p

Incremental cost-effectiveness for the 10 000 Monte Carlo simulations on the cost-effective plane.

<p>The scatterplots show the distribution of the incremental cost-effectiveness ratio for the different strategies. The ellipses show the central 95th percentile of each distribution. The overlaid lines have slopes that are equal to the willingness-to-pay threshold (€40000).</p

Stepwise marginal regression analysis of variables influencing MAD therapy with center as a cluster variable (n = 2822).

<p>Stepwise marginal regression analysis of variables influencing MAD therapy with center as a cluster variable (n = 2822).</p

Stepwise regression analysis of variables influencing MAD therapy (n = 2822).

<p>Stepwise regression analysis of variables influencing MAD therapy (n = 2822).</p

Baseline characteristics of patients treated by MAD and patients treated by CPAP.

<p>Results are presented as percentages unless otherwise indicated. Significant level for p value: <0.05.</p

Cost-effectiveness ratio.

<p>Cost-Effectiveness ratios (CE ratio) are expressed in Euros per QALY (€/Q).</p

Costs of different strategies according to their effectiveness and the CP intervention cost.

<p>The strategies included in quadrant I were more effective and more costly than “<i>Screening strategy without CP</i>”. The strategies included in quadrant II were less effective and more costly (dominated); the strategies included in quadrant III were less effective and less costly; and the strategies included in quadrant IV were more effective and less costly (dominant). The slope of the line between any two points represents the incremental cost-effectiveness ratio for two pathways.</p

Stepwise regression analysis of variables influencing CPAP adherence.

<p>Abbreviations: CPAP, continuous positive airway pressure; AHI, apnea-hypopnea index;</p><p>CPAP adherence: CPAP use ≥4 h/night.</p><p>Significant level for p value: <0.05.</p><p>Area under the ROC: 0.607.</p

Baseline characteristics of adherent and non-adherent patients.^*

<p>*Results presented as mean (standard deviation) unless otherwise indicated.</p><p>Adherent patients: continuous positive airway pressure (CPAP) use ≥4 h/night.</p><p>Non-adherent patients: CPAP refused or abandoned, or CPAP use<4 h/night.</p><p>Significant level for p value: <0.05.</p

Flow diagram of subjects during the study.

<p>Abbreviations: CPAP: continuous positive airway pressure; IRSR, Institut de Recherche en Santé Respiratoire des Pays de la Loire.</p