7 research outputs found
Sorazolons, Carbazole Alkaloids from <i>Sorangium cellulosum</i> Strain Soce375
Sorazolons A (<b>1</b>) to E2 (<b>9</b>) were isolated
from <i>Sorangium cellulosum</i> strain Soce375. Their molecular
structures were elucidated using extensive HRESIMS and NMR analysis.
The absolute configuration of sorazolon A (<b>1</b>) was determined
by comparison of the experimental CD spectrum with quantum chemical
calculated spectra for both enantiomers. Sorazolons D2 (<b>7</b>), E (<b>8</b>), and E2 (<b>9</b>) exhibit a moderate
cytotoxic activity against mouse fibroblast cell line L929 with IC<sub>50</sub> values between 5.0 μM and 0.09 mM
3-(1<em>H</em>-Indol-3-yl)-4-(morpholin-4-yl)cyclobut-3-ene-1,2-dione
3-(1<em>H</em>-Indol-3-yl)-4-(morpholin-4-yl)cyclobut-3-ene-1,2-dione was obtained in good yields (72–82%) by nucleophilic substitution of 3-chloro-4-(1<em>H</em>-indol-3-yl)cyclobut-3-ene-1,2-dione with morpholine