Visualizing the Results of a Complex Hybrid Dynamic-Static Analysis

Complex static or hybrid static-dynamic analyses produce large quantities of structured data. In the past, this data was generally intended for use by compilers or other software tools that used the produced information to transform the application being analyzed. However, it is becomingly increasingly common for the results of these analyses to be used directly by humans. For example, in our own prior work we have developed a hybrid dynamic-static escape analysis intended to help developers identify sources of object churn within large framework-base applications. In order to facilitate human use of complex analysis results, visualizations need to be developed that allow a user to browse these results and to identify the points of interest within these large data sets. In this paper we present Hi-C, a visualization tool for our hybrid escape analysis that has been implemented as an Eclipse plugin. We show how Hi-C can help developers identify sources of object churn in a large framework-based application and how we have used the tool to assist in understanding the results of a complex analysis

The IRAS 1.2 Jy Survey: Redshift Data

We present the redshift data for a survey of galaxies selected from the data base of the Infrared Astronomical Satellite (IRAS). This survey extends the 1.936 Jy sample of Strauss et al. (1992) from a flux limit of 1.936 Jy at 60 microns to 1.2 Jy. The survey extension consists of 3920 sources in the flux interval 1.2 - 1.936 Jy, of which 2663 are galaxies with measured redshifts. Fourteen objects (0.52%) do not have redshifts. The survey covers 87.6% of the sky. The data for the complete 1.2 Jy survey (the data presented here in addition to that of Strauss \etal 1992) may be obtained in a machine-readable form from the National Space Science Data Center and from the anonymous ftp site given above.Comment: uuencoded postscript file. Figures, data tables, and machine readable data files can be obtained via anonymous ftp to (192.16.204.30) ftp://eku.ias.edu/pub/fisher/12jy/12jy.tar.Z (a compressed tar file)

A call for transparent reporting to optimize the predictive value of preclinical research

The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress

The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats

BACKGROUND AND PURPOSE: Cerebral white matter is as sensitive as gray matter to ischemic injury and is probably amenable to pharmacological intervention. In this study we investigated whether an N-methyl-D-aspartate (NMDA) antagonist, CNS 1102, protects not only cerebral gray matter but also white matter from ischemic injury. METHODS: Ten rats underwent 15 minutes of temporary focal ischemia and were blindly assigned to CNS 1102 intravenous bolus injection (1. 13 mg/kg) followed by intravenous infusion (0.33 mg/kg per hour) for 3.75 hours or to vehicle (n=5 per group) immediately after reperfusion. Seventy-two hours after ischemia, the animals were perfusion fixed for histology. The severity of neuronal necrosis in the cortex and striatum was semiquantitatively analyzed. The Luxol fast blue-periodic acid Schiff stain and Bielschowsky\u27s silver stain were used to measure optical densities (ODs) of myelin and axons, respectively, in the internal capsule of both hemispheres, and the OD ratio was calculated to reflect the severity of white matter damage. RESULTS: Neuronal damage in both the cortex and the striatum was significantly better in the drug-treated group than in the placebo group (P\u3c0.05). The OD ratio of both the axons (0.93+/-0.08 versus 0.61+/-0.18; P\u3c0.01) and the myelin sheath (0.95+/-0.07 versus 0.67+/-0.19; P=0.01) was significantly higher in the CNS 1102 group than in the placebo group. The neurological score was significantly improved in the drug-treated group (P\u3c0.05). CONCLUSIONS: The NMDA receptor antagonist CNS 1102 protects not only cerebral gray matter but also white matter from ischemic injury, most probably by preventing degeneration of white matter structures such as myelin and axons