2,068 research outputs found

    How to Evaluate your Question Answering System Every Day and Still Get Real Work Done

    Full text link
    In this paper, we report on Qaviar, an experimental automated evaluation system for question answering applications. The goal of our research was to find an automatically calculated measure that correlates well with human judges' assessment of answer correctness in the context of question answering tasks. Qaviar judges the response by computing recall against the stemmed content words in the human-generated answer key. It counts the answer correct if it exceeds agiven recall threshold. We determined that the answer correctness predicted by Qaviar agreed with the human 93% to 95% of the time. 41 question-answering systems were ranked by both Qaviar and human assessors, and these rankings correlated with a Kendall's Tau measure of 0.920, compared to a correlation of 0.956 between human assessors on the same data.Comment: 6 pages, 3 figures, to appear in Proceedings of the Second International Conference on Language Resources and Evaluation (LREC 2000

    ZMIZ1 Preferably Enhances the Transcriptional Activity of Androgen Receptor with Short Polyglutamine Tract

    Get PDF
    The androgen receptor (AR) is a ligand-induced transcription factor and contains the polyglutamine (polyQ) tracts within its N-terminal transactivation domain. The length of polyQ tracts has been suggested to alter AR transcriptional activity in prostate cancer along with other endocrine and neurologic disorders. Here, we assessed the role of ZMIZ1, an AR co-activator, in regulating the activity of the AR with different lengths of polyQ tracts as ARQ9, ARQ24, and ARQ35 in prostate cancer cells. ZMIZ1, but not ZMIZ2 or ARA70, preferably augments ARQ9 induced androgen-dependent transcription on three different androgen-inducible promoter/reporter vectors. A strong protein-protein interaction between ZMIZ1 and ARQ9 proteins was shown by immunoprecipitation assays. In the presence of ZMIZ1, the N and C-terminal interaction of the ARQ9 was more pronounced than ARQ24 and ARQ35. Both Brg1 and BAF57, the components of SWI/SNF complexes, were shown to be involved in the enhancement of ZMIZ1 on AR activity. Using the chromatin immunoprecipitation assays (ChIP), we further demonstrated a strong recruitment of ZMIZ1 by ARQ9 on the promoter of the prostate specific antigen (PSA) gene. These results demonstrate a novel regulatory role of ZMIZ1 in modulating the polyQ tract length of AR in prostate cancer cells

    Natural Resources, Investment and Long-Term Income

    Full text link

    Modelling Dynamic Conditional Correlations in WTI Oil Forward and Futures Returns

    Full text link

    Does Endogenous Technical Change Make a Difference in Climate Policy Analysis? A Robustness Exercise with the FEEM-RICE Model

    Full text link

    Interactions Between Climate and Trade Policies: A Survey

    Full text link

    The Stability of the Adjusted and Unadjusted Environmental Kuznets Curve

    Full text link

    Equilibrium with a Market of Permits

    Full text link
    • …
    corecore