Percentage of subjects responding to DTH induced by candida antigen.

<p>Bar insets represent number of positive responders (numerator) over total number of subjects (denominator) in each group.</p

Odds ratios for positive DTH response by CRP level.

*<p>Significantly increased odds of developing a positive DTH response (p<0.05). CI, confidence interval. % Responders represents percentage of total responders (N = 28) per group.</p

Baseline characteristics.

<p>Values shown are mean ± SEM. Parenthetical values shown are (median, range). yr: years of age. bpm: beats per minute. #: total number of medications.</p

Immune Function Intervention Trial CONSORT diagram.

<p>Immune Function Intervention Trial CONSORT diagram.</p

Correlation between DTH response to candida antigen and predictor variables in positive responders.

*<p>Significant correlation between variables (p<0.05). VO₂, volume of oxygen consumption; BMI, body mass index; RHR, resting heart rate; CRP, C-reactive protein; Meds, anti-inflammatory medications; DTH, delayed-type hypersensitivity; bpm, beats per minute.</p

CRP values among responders and non-responders to DTH induced by candida antigen.

<p>*Significantly different compared to non-responders (p<0.05). Values are mean ± SEM.</p

Magnitude of DTH response among positive responders to candida antigen.

<p>Values are mean ± SEM.</p

Exercise hemodynamic and water intake.

<p>Exercise hemodynamic and water intake.</p

Subject characteristics.

<p>Subject characteristics.</p

A schematic of the study design showing the procedures for each visit.

<p>Subjects underwent testing to determine peak oxygen uptake (VO_2peak) and a blood draw prior to randomization to placebo or histamine blockade (Visit 1). The order in which the blockade/placebo (visits 2 or 3) were administered was randomized. During study visits 2 and 3, cardiovascular (CV) measurements were obtained at rest and at 30 min, 60 min and 90 min post-exercise (during recovery).</p