243 research outputs found
Role of the High Affinity Immunoglobulin E Receptor in Bacterial Translocation and Intestinal Inflammation
A role for immunoglobulin E and its high affinity receptor (FcεRI) in the control of bacterial pathogenicity and intestinal inflammation has been suggested, but relevant animal models are lacking. Here we compare transgenic mice expressing a humanized FcεRI (hFcεRI), with a cell distribution similar to that in humans, to FcεRI-deficient animals. In hFcεRI transgenic mice, levels of colonic interleukin 4 were higher, the composition of fecal flora was greatly modified, and bacterial translocation towards mesenteric lymph nodes was increased. In hFcεRI transgenic mice, 2,4,6-tri-nitrobenzenesulfonic acid (TNBS)-induced colitis was also more pronounced, whereas FcεRI-deficient animals were protected from colitis, demonstrating that FcεRI can affect the onset of intestinal inflammation
Stress urinary incontinence after holmium laser enucleation of prostate: incidence and risk factors
Background and objective: To evaluate the incidence and the risk
factors of stress urinary incontinence (SUI) during the first year following
Holmium Laser Enucleation of the Prostate (HoLEP).
Materials and methods: Our monocentric and retrospective study includes
155 patients who underwent HoLEP for benign prostatic hyperplasia. Surgeries were
performed by 2 expert surgeons. The continence was evaluated before and after
surgery at 1, 3, 6 and 12 months. The predictive factors of SUI were analysed
using logistic regression.
Results: The SUI rate at 1, 3, 6 and 12 months was respectively 7.3%,
8.1%, 3.4% and 2.7%. SUI remained present in 4 patients (2.6%) at 12 months.
The mean International Consultation Incontinence Questionnaire Urinary
Incontinence Short Form (ICIQ-SF) score for patients with SUI was respectively
11.69 ± 5.28, 8.70 ± 4.24, 1.81 ± 3.53 and 8 ± 4.24 at 1,
3, 6 and 12 months (p 30 (Odds Ratio
(OR), 4.69; 95% Confidence Interval (CI), 1.51–14.52; p = 0.007) and
patients over 70 years old (OR, 16.23; 95% CI, 1.96–134.09; p = 0.010)
were respectively identified as independent risk factors for SUI at 1 and 3
months.
Conclusions: SUI after HoLEP is transitory in most cases. It is
favoured by a high BMI and an age over 70. These criteria should be considered
before choosing the operative technique and preventive measures must be taken in
high-risk patients
Pyrale du buis : une efficacité insuffisante des trichogrammes
editorial reviewedsavebuxus - Afin de poursuivre
la mise au point de la lutte contre la
pyrale du buis, Cydalima perspectalis, à
l’aide de trichogrammes, le programme
national SaveBuxus se prolonge jusqu’à
décembre 2019.
étude - Après un screening d’une
cinquantaine de souches de trichogramme
en laboratoire, trois espèces
ont été retenues pour les essais in situ
de 2018 : Trichogramma brassicae, Trichogramma
dendrolimi et la souche
du produit Trichotop Buxus (commercialisée
depuis 2016 en France). Les
essais ont eu lieu sur un site expérimental
d’Astredhor Sud-Ouest sur des buis
infestés grâce aux pyrales de l’élevage
de l’Inra UEFM Antibes. Des lâchers
hebdomadaires des trois espèces de
trichogrammes ont été réalisés pendant
toute la période de vol du ravageur,
entre juin et octobre, sur buis linéaires
et buis isolés. En 2018, la densité du
ravageur insignifiante n’a pas permis
d’évaluer l’efficacité des trichogrammes
pour parasiter et tuer les oeufs de pyrale.
Il y a donc eu recours à des oeufs
d’élevage produits au laboratoire de
l’Inra d’Antibes et envoyés avec des
brins de buis sur le terrain. Les brins
portant les oeufs étaient disposés le
jour de réception sur les buis de la zone
d’essai. Au bout de 5 jours, ils étaient
récupérés et renvoyés à Antibes pour
mise en incubation 6 jours à 25 °C avant
analyse des taux d’avortement et de
parasitisme des oeufs. La capacité de
dispersion des trichogrammes a également
été évaluée
Developing an instrument to assess the endoscopic severity of ulcerative colitis : The Ulcerative Colitis Endoscopic Index of Severity (UCEIS)
Full list of Investigators is given at the end of the article.Background: Variability in endoscopic assessment necessitates rigorous investigation of descriptors for scoring severity of ulcerative colitis (UC). Objective: To evaluate variation in the overall endoscopic assessment of severity, the intra- and interindividual variation of descriptive terms and to create an Ulcerative Colitis Endoscopic Index of Severity which could be validated. Design: A two-phase study used a library of 670 video sigmoidoscopies from patients with Mayo Clinic scores 0-11, supplemented by 10 videos from five people without UC and five hospitalised patients with acute severe UC. In phase 1, each of 10 investigators viewed 16/24 videos to assess agreement on the Baron score with a central reader and agreed definitions of 10 endoscopic descriptors. In phase 2, each of 30 different investigators rated 25/60 different videos for the descriptors and assessed overall severity on a 0-100 visual analogue scale. κ Statistics tested inter- and intraobserver variability for each descriptor. A general linear mixed regression model based on logit link and β distribution of variance was used to predict overall endoscopic severity from descriptors. Results: There was 76% agreement for 'severe', but 27% agreement for 'normal' appearances between phase I investigators and the central reader. In phase 2, weighted κ values ranged from 0.34 to 0.65 and 0.30 to 0.45 within and between observers for the 10 descriptors. The final model incorporated vascular pattern, (normal/patchy/ complete obliteration) bleeding (none/mucosal/luminal mild/luminal moderate or severe), erosions and ulcers (none/erosions/superficial/deep), each with precise definitions, which explained 90% of the variance (pR2, Akaike Information Criterion) in the overall assessment of endoscopic severity, predictions varying from 4 to 93 on a 100-point scale (from normal to worst endoscopic severity). Conclusion: The Ulcerative Colitis Endoscopic Index of Severity accurately predicts overall assessment of endoscopic severity of UC. Validity and responsiveness need further testing before it can be applied as an outcome measure in clinical trials or clinical practice.publishersversionPeer reviewe
Intérêt et crédibilité des enquêtes médico-marketing financées par l'industrie du médicament (analyse critique à la lumière d'un exemple suisse)
LYON1-BU Santé (693882101) / SudocSudocFranceF
Localisation des récidives locales des cancers de prostate après traitement par ultrasons focalisés de haute intensité (étude rétrospective de 325 biopsies de prostate)
LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
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