Parameters used in the model and their source.

<p>Parameters used in the model and their source.</p

Univariate sensitivity analysis (Tornado diagram).

<p>The tornado diagram shows that there is significant uncertainty in the results, especially with regards to mortality.</p

Le Courrier

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Decision tree.

<p>Decision tree showing the decision tree pathways in the people with body and tail of pancreatic cancer who underwent distal pancreatectomy.</p

Cost-effectiveness acceptability curve.

<p>The cost-effectiveness acceptability curve shows that the probability laparoscopic distal pancreatectomy was cost-effective compared to open distal pancreatectomy was 70% to 80% at the willingness-to-pay thresholds generally used in England (£20,000 to £30,000 per QALY gained).</p

Scatter plot of incremental cost per incremental quality-adjusted life year.

<p>The scatter plot shows that the points lie almost symmetrical about the X-axis, i.e. the costs were similar between laparoscopic and open distal pancreatectomy, but most points lie to the right of the Y-axis, i.e. laparoscopic distal pancreatectomy was associated with increased quality-adjusted life years (QALYs).</p

Additional file 1: of Fluid hydration to prevent post-ERCP pancreatitis in average- to high-risk patients receiving prophylactic rectal NSAIDs (FLUYT trial): study protocol for a randomized controlled trial

Definitions of secondary endpoints. Table S1. Severity of PEP according to Cotton and revised Atlanta criteria. Table S2. Local and systemic complications according to (revised) Atlanta criteria. Table S3. ERCP-related complications (adopted from Cotton). SPIRIT checklist. (DOCX 40 kb

Additional file 1: Figure S1. of Early biliary decompression versus conservative treatment in acute biliary pancreatitis (APEC trial): study protocol for a randomized controlled trial

Flowchart APEC trial according to CONSORT [43]. (PDF 6 kb

Additional file 3: Table S1. of Early biliary decompression versus conservative treatment in acute biliary pancreatitis (APEC trial): study protocol for a randomized controlled trial

Definitions of the primary endpoint. (DOC 35 kb

Additional file 1: of Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial

SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 112 kb