386 research outputs found
A Lithocodium and Bacinella signature of a late Hauterivian, local microbial event: the Urgonian limestone in South-East France
Sediment binding crusts of Lithocodium aggregatum and associated Bacinella irregularis abound in a shallow water limestone layer, in SouthâEast France. The sudden appearance of these crusts denotes a local, conspicuous change in an otherwise balanced, open marine depositional environment. Based on regional correlation, the layer belongs to the Lower Hauterivian, Ligatus Zone, directly dated by an assemblage of orbitolinid foraminifera, and indirectly by a specimen of ammonite. It is older than the Faraoni oceanic anoxic event (OAE), (latest Hauterivian, Angulicostata auct. Zone), and presumably not linked with a global climate change. Two facies are recognized: (1) Lithocodium bindstone, with Bacinella, other microencrusters, and fluorescent automicrite of microbial origin; (2) fl oatstones containing numerous fragments of Lithocodium and accompanying biota. Coarse rhombohedral dolomite is locally present. Two modern analogues of microbial mediation are put forward to explain the Lithocodium event: (a) Lagoa Vermelha, in Brazil, along with anoxic, marginal marine conditions; (b) Highborne Cay, in the Bahamas, along with oxic, open marine conditions. A stack of four Upper Hauterivian parasequences is described: Parasequence 1 ends with oolitic deposits; the somewhat deeper water Parasequence 2 occurs only in the south-eastern part of the study area, towards the Subalpine depocenter; Parasequence 3 matches the layer with Lithocodium and Bacinella, of variable thickness (0.8 m â 11 m), resulting from syn-sedimentary tectonic activity in the area of the Vuache fault system which is a major feature; Parasequence 4 corresponds with the resumption of the normal, Urgonian carbonate factory
Parcours spécifiques : allier réussite et contraintes individuelles
Comprend des rĂ©fĂ©rences bibliographiquesDepuis plus de douze ans, une structure spĂ©ciale et efficace a Ă©tĂ© mise en place au sein de lâInstitut Universitaire de Technologie 1 de Grenoble afin dâaccueillir et dâaccompagner les nombreux Ă©tudiants ayant des contraintes fortes dans le dĂ©roulement de leurs Ă©tudes. Celle-ci propose des adaptations pour tous types de contraintes individuelles et repose sur une Ă©quipe de correspondants et de tuteurs dans chaque dĂ©partement dâenseignement. Les taux de rĂ©ussite obtenus sont les mĂȘmes que ceux des Ă©tudiants nâayant pas de contraintes particuliĂšres ce qui prouve que la compensation des contraintes est bien effectuĂ©e. Cependant, les restrictions budgĂ©taires actuelles risquent de remettre en cause ces adaptations bien quâelles soient peu onĂ©reuses
Life-Sized Audiovisual Spatial Social Scenes with Multiple Characters: MARC & SMART-IÂČ
International audienceWith the increasing use of virtual characters in virtual and mixed reality settings, the coordination of realism in audiovisual rendering and expressive virtual characters becomes a key issue. In this paper we introduce a new system combining two systems for tackling the issue of realism and high quality in audiovisual rendering and life-sized expressive characters. The goal of the resulting SMART-MARC platform is to investigate the impact of realism on multiple levels: spatial audiovisual rendering of a scene, appearance and expressive behaviors of virtual characters. Potential interactive applications include mediated communication in virtual worlds, therapy, game, arts and elearning. Future experimental studies will focus on 3D audio/visual coherence, social perception and ecologically valid interaction scenes
The Cretaceous of the Swiss Jura Mountains: an improved lithostratigraphic scheme
In the course of the HARMOS project of the Swiss Geological Survey, the lithostratigraphic subdivisions of the Cretaceous sedimentary rocks outcropping in the Swiss Jura Mountains were revisited. New formation names are proposed where only inadequate facies terms existed so far. As in some cases outcrop conditions in the Swiss Jura do not allow for logging complete sections to characterise the formations, type localities in neighbouring France have been chosen. The following formations (Fm.) are defined to describe the Cretaceous lithological units (from bottom to top): Goldberg Fm., Pierre-ChĂątel Fm., Vions Fm., Chambotte Fm., Vuache Fm., Grand Essert Fm., Gorges de lâOrbe Fm., Vallorbe Fm., Perte du RhĂŽne Fm., Narlay Fm. Dating of the formations is based on biostratigraphy (ammonites, echinids, dasycladalean algae, foraminifera, calpionellids, dinocysts, nannofossils). The fossils indicate Berriasian through to Coniacian ages. The lithostratigraphic units describe the general evolution from a shallow, peritidal platform to deeper-water shelf environments, then the installation of a carbonate platform, and finally the drowning of this platform followed by the predominance of pelagic conditions. The common lateral and vertical changes in facies and sedimentation rates as well as numerous hiatuses within the formations testify to a complex interplay of tectonics, climate, and sea level that controlled the Swiss Jura realm during the Cretaceous
Successful Treatment of Anterior Tracheal Necrosis after Total Thyroidectomy Using Vacuum-Assisted Closure Therapy
Total thyroidectomy involving the adjacent structures of the trachea can cause tracheal damage such as early tracheal necrosis. The authors describe the first case of anterior tracheal necrosis following total thyroidectomy treated using vacuum-assisted closure device. After two weeks of VACââtherapy, there was no evidence of ongoing infection and the trachea was partially closed around a tracheotomy cannula, removed after 3 months. The use of a VACââtherapy to reduce and close the tracheal rent and to create a rapid granulation tissue over tracheal structure appeared as a good opportunity after anterior tracheal necrosis
Leptospirosis: An Unusual Cause of ARDS
Severe leptospirosis usually associates shock, jaundice, renal failure, and thrombocytopenia. Massive hemoptysis due to diffuse alveolar haemorrhage may rarely occur leading to an acute respiratory failure and multiple organ failure. We present the case of an acute respiratory distress syndrome caused by a severe leptospirosis. The severity of the respiratory failure contrasted with the absence of significant liver or renal dysfunction. Bedside open lung biopsy was only consistent with a postinfectious BOOP. The diagnosis was retrospective when the niece of the patient presented with similar inaugural symptoms ten days later after being scratched by a wild rat which was considered by our patient as a pet
Echocardiographic assessment of pulmonary artery occlusion pressure in ventilated patients: a transoesophageal study
A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilatorassociated pneumonia
INTRODUCTION: The aim of this study was to compare a 7-day course of doripenem to a 10-day course of imipenem-cilastatin for ventilator-associated pneumonia (VAP) due to Gram-negative bacteria. METHODS: This was a prospective, double-blinded, randomized trial comparing a fixed 7-day course of doripenem one gram as a four-hour infusion every eight hours with a fixed 10-day course of imipenem-cilastatin one gram as a one-hour infusion every eight hours (April 2008 through June 2011). RESULTS: The study was stopped prematurely at the recommendation of the Independent Data Monitoring Committee that was blinded to treatment arm assignment and performed a scheduled review of data which showed signals that were close to the pre-specified stopping limits. The final analyses included 274 randomized patients. The clinical cure rate at the end of therapy (EOT) in the microbiological intent-to-treat (MITT) population was numerically lower for patients in the doripenem arm compared to the imipenem-cilastatin arm (45.6% versus 56.8%; 95% CI, -26.3% to 3.8%). Similarly, the clinical cure rate at EOT was numerically lower for patients with Pseudomonas aeruginosa VAP, the most common Gram-negative pathogen, in the doripenem arm compared to the imipenem-cilastatin arm (41.2% versus 60.0%; 95% CI, -57.2 to 19.5). All cause 28-day mortality in the MITT group was numerically greater for patients in the doripenem arm compared to the imipenem-cilastatin arm (21.5% versus 14.8%; 95% CI, -5.0 to 18.5) and for patients with P. aeruginosa VAP (35.3% versus 0.0%; 95% CI, 12.6 to 58.0). CONCLUSIONS: Among patients with microbiologically confirmed late-onset VAP, a fixed 7-day course of doripenem was found to have non-significant higher rates of clinical failure and mortality compared to a fixed 10-day course of imipenem-cilastatin. Consideration should be given to treating patients with VAP for more than seven days to optimize clinical outcome. TRIAL REGISTRATION: ClinicalTrials.gov: NCT0058969
COP1, a Negative Regulator of Photomorphogenesis, Positively Regulates Plant Disease Resistance via Double-Stranded RNA Binding Proteins
The E3 ubiquitin ligase COP1 (Constitutive Photomorphogenesis 1) is a well known component of the light-mediated plant development that acts as a repressor of photomorphogenesis. Here we show that COP1 positively regulates defense against turnip crinkle virus (TCV) and avrRPM1 bacteria by contributing to stability of resistance (R) protein HRT and RPM1, respectively. HRT and RPM1 levels and thereby pathogen resistance is significantly reduced in the cop1 mutant background. Notably, the levels of at least two double-stranded RNA binding (DRB) proteins DRB1 and DRB4 are reduced in the cop1 mutant background suggesting that COP1 affects HRT stability via its effect on the DRB proteins. Indeed, a mutation in either drb1 or drb4 resulted in degradation of HRT. In contrast to COP1, a multi-subunit E3 ligase encoded by anaphase-promoting complex (APC) 10 negatively regulates DRB4 and TCV resistance but had no effect on DRB1 levels. We propose that COP1-mediated positive regulation of HRT is dependent on a balance between COP1 and negative regulators that target DRB1 and DRB4
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