Development Of A New Probe For Specific And Sensitive Detection Of 'Candidatus Phytoplasma Mali' In Inoculated Apple Trees

peer reviewe

Cost-Effectiveness of Magnetic Resonance Imaging with a New Contrast Agent for the Early Diagnosis of Alzheimer's Disease

Background: Used as contrast agents for brain magnetic resonance imaging (MRI), markers for beta-amyloid deposits might allow early diagnosis of Alzheimer’s disease (AD). We evaluated the cost-effectiveness of such a diagnostic test, MRI+CLP (contrastophore-linker-pharmacophore), should it become clinically available. Methodology/Principal Findings: We compared the cost-effectiveness of MRI+CLP to that of standard diagnosis using currently available cognition tests and of standard MRI, and investigated the impact of a hypothetical treatment efficient in early AD. The primary analysis was based on the current French context for 70-year-old patients with Mild Cognitive Impairment (MCI). In alternative ‘‘screen and treat’ ’ scenarios, we analyzed the consequences of systematic screenings of over-60 individuals (either population-wide or restricted to the ApoE4 genotype population). We used a Markov model of AD progression; model parameters, as well as incurred costs and quality-of-life weights in France were taken from the literature. We performed univariate and probabilistic multivariate sensitivity analyses. The base-case preferred strategy was the standard MRI diagnosis strategy. In the primary analysis however, MRI+CLP could become the preferred strategy under a wide array of scenarios involving lower cost and/or higher sensitivity or specificity. By contrast, in the ‘‘screen and treat’’ analyses, the probability of MRI+CLP becoming the preferred strategy remained lower than 5%. Conclusions/Significance: It is thought that anti-beta-amyloid compounds might halt the development of dementia i

Début de carrière des cadres débutants en PME des secteurs du conseil informatique et de la construction : éléments de cadrage

International audienc

Début de carrière des cadres débutants en PME des secteurs du conseil informatique et de la construction : éléments de cadrage

International audienc

CAMAC booster ('CAB' system) A versatile microcomputer for high rate CAMAC data acquisition technical presentation

Reports the present status of CAB from the points of view of hardware and software. CAB is a microprogrammable system, using fast TTL bit- slice technology, designed to improve the capabilities of a standard CAMAC data acquisition chain. It can be implemented as crate controller, branch driver, or computer to CAMAC (or GPIB to CAMAC) interface. It is well adapted to a wide range of complex applications, such as software triggering, event filtering, data compaction and formatting, equipment calibration and monitoring. The basic software includes a cross-assembler, an emulating program and an interactive debugger. Improvements are now under development. Today, more than 15 units are used in different laboratories. (0 refs)

CAMAC booster ("CAB" system): a versatile microcomputer for high rate CAMAC data acquisition

Reports the present status of CAB from the points of view of hardware and software. CAB is a microprogrammable system, using fast TTL bit- slice technology, designed to improve the capabilities of a standard CAMAC data acquisition chain. It can be implemented as crate controller, branch driver, or computer to CAMAC (or GPIB to CAMAC) interface. It is well adapted to a wide range of complex applications, such as software triggering, event filtering, data compaction and formatting, equipment calibration and monitoring. The basic software includes a cross-assembler, an emulating program and an interactive debugger. Improvements are now under development. Today, more than 15 units are used in different laboratories. (0 refs)

Notre Maîtrise métropolitaine, son histoire,

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Début de carrière des cadres débutants en PME des secteurs du conseil informatique et de la construction : éléments de cadrage

International audienc