DTIE, a novel core promoter element that directs start site selection in TATA-less genes

La sustentabilidad es uno de los paradigmas que caracterizan al siglo XXI y como tal debe ser incorporada en la conducción de organizaciones. Peter Drucker sostenía que “las viejas formas de dirección de empresas no prestaron atención a las personas ni a los valores, por el contrario, los han subestimado y anulado, de esa manera han debilitado las posibilidades de desarrollo atentando contra sus propios objetivos económicos” (citado en Cleri, 2007, p.187). Este artículo tiene la finalidad de contribuir a la revisión de esas viejas formas de conducción, a partir de la reflexión sobre la siguiente premisa: una organización sustentable es aquella culturalmente responsable. Hoy se dispone de las herramientas necesarias para asumir el desafío de administrar organizaciones sustentables y, en ese sentido, se aportan los Modelos de Administración Sustentable (MAS) y de Evaluación de la Sustentabilidad Organizacional (MESO), planteando, en ambos casos una reformulación explicativa sobre sus enunciaciones originales. Las organizaciones deben reconocer su rol como miembros de la sociedad, incorporando modalidades de conducción que viabilicen un comportamiento ético y responsable, con compromiso sustentable.Sustainability is one of the paradigms that characterize the 21st century and, as such, it must be incorporated into the management of organizations. Peter Drucker argued that “the old forms of business management did not pay attention to people or values, on the contrary, they have underestimated and annulled them, thereby weakening the possibilities of development against their own economic objectives” (Cleri, 2007, p.187). This article aims to contribute to the revision of these old ways of management from the reflection on the following premise: a sustainable organization is a culturally responsible one. Nowadays, the necessary tools to take on the challenge of managing sustainable organizations are available and, in this sense, the Sustainable Management Model (Spanish acronym: MAS) and the Organizational Sustainability Assessment Model (Spanish acronym: MESO) are provided, proposing, in both cases, an explanatory reformulation of its original enunciations. Organizations must recognize their role as members of society, incorporating management modalities that enable an ethical and responsible behavior, with sustainable commitment.Facultad de Ciencias Económica

ILDR2 is a novel B7-like protein that negatively regulates T cell responses

The B7-like protein family members play critical immunomodulatory roles and constitute attractive targets for the development of novel therapies for human diseases. We identified Ig-like domain-containing receptor (ILDR)2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues. A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells. Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer