Final body weight, organ and gut content weight for lean (Le) and obese (Ob) female Zucker rats fed the control diet (CT) or the diet supplemented with RE enriched in CA (40%).

<p>The content of CA, carnosol and methyl carnosate detected in these samples is also indicated.</p>a<p>: Organs and gut content were collected and weighed at the end of the experimental procedure.</p>b<p>: Values are the mean ± SD (n = 7 for lean animals and n = 5 for obese animals) and are expressed as g of fresh weight (f.w.);</p>c<p>: jejunum+ileum; N.D.: Not detected.</p

Effects of the consumption of RE on lipase activity in Zucker female rats.

<p>Lean (Le) and obese (Ob) rats fed the control diet (CT) or the diet supplemented with RE (RE). Activity (expressed in nkats/g) was measured as the hydrolysis of PNPB in a) stomach content, b) duodenum content, c) small intestine (jejunum+ileum) content, d) liver and e) pancreas. Data are presented as the mean value ± SD (n = 7 for lean animals and n = 5 for obese animals). ^#<i>P</i><0.1, * <i>P</i><0.05 and ** <i>P</i><0.01 compared to their respective CT values.</p

List of phenolic compounds identified in the rosemary extract (RE) by their retention times, UV-Vis and mass spectra and by the use of standards.

*<p>: shoulder</p

Effects of the consumption of RE on body weight (g) and food utility index (FUI) in Zucker female rats.

<p>Lean (Le) and obese (Ob) rats were fed the control diet (CT) or the diet supplemented with 0.05% of RE (RE) for 64 days. Data are presented as the mean value ± SD (n = 7 for lean animals and n = 5 for obese animals). * <i>P</i><0.05, ** <i>P</i><0.01 compared to their respective CT values.</p

Main phenolic compounds present in the rosemary extract (RE).

<p>Chromatogram (285 nm) corresponding to the HPLC-DAD-MS analysis of the RE extract. The structure and peak identification of carnosol (peak 10) and CA (carnosic acid, peak 14) are indicated. Peak numbers correspond to each of the phenolic compounds identified in the extract and listed in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039773#pone-0039773-t001" target="_blank">Table 1</a>.</p

Effects of the consumption of RE on plasma levels of the hepatic enzymes ALP and ALT (U/L) in Zucker female rats.

<p>Lean (Le) and obese (Ob) rats fed the control diet (CT) or the diet supplemented with RE (RE). Data are presented as the mean value ± SD (n = 7 for lean animals and n = 5 for obese animals). * <i>P</i><0.05 compared to their respective CT values.</p