Priority projects for the implementation of CCS power generation with enhanced oil recovery in Mexico

In March 2014, Mexico launched its CCUS technology roadmap, outlining the actions to be taken up to 2024. One important action is the National Policy of Carbon Capture and Storage (CCS) ready and the identification of priority natural gas combined cycle (NGCC) with capture plants. This outcome could aid the creation of a technology roadmap for the design of new NGCC power plants and their operational requirements for EOR and for the reduction of CO 2 emissions. This article provides an overview of the opportunities for deploying CCS in new NGCC power plants in Mexico which were programed to begin operation throughout the period from 2016 to 2030. The attention is given to plants close to oil fields which are candidates for enhanced oil recovery (EOR), located in an inclusion zone suitable for storage. The Gulf of Mexico region, where potential EOR sites and the presence of industrial CO 2 sources are located, is within the inclusion zone for recommended sites for geological storage of CO 2 . After identifying new power plants in the inclusion zone, this article analyses which existing plants could be retrofitted and which new power plants could be designed to be ‘carbon capture ready’. In addition, the distance and the volumes of CO 2 are estimated

Design, Synthesis and Biological Evaluation of 2-(2-Amino-5(6)-nitro-1H-benzimidazol-1-yl)-N-arylacetamides as Antiprotozoal Agents

Parasitic diseases are a public health problem affecting millions of people worldwide. One of the scaffolds used in several drugs for the treatment of parasitic diseases is the benzimidazole moiety, a heterocyclic aromatic compound. This compound is a crucial pharmacophore group and is considered a privileged structure in medicinal chemistry. In this study, the benzimidazole core served as a model for the synthesis of a series of 2-(2-amino-5(6)-nitro-1H-benzimidazol-1-yl)-N-arylacetamides 1–8 as benznidazole analogues. The in silico pharmacological results calculated with PASS platform exhibited chemical structures highly similar to known antiprotozoal drugs. Compounds 1–8 when evaluated in silico for acute toxicity by oral dosing, were less toxic than benznidazole. The synthesis of compounds 1–8 were carried out through reaction of 5(6)-nitro-1H-benzimidazol-2-amine (12) with 2-chlroactemides 10a–h, in the presence of K2CO3 and acetonitrile as solvent, showing an inseparable mixture of two regioisomers with the -NO2 group in position 5 or 6 with chemical yields of 60 to 94%. The prediction of the NMR spectra of molecule 1 coincided with the experimental chemical displacements of the regioisomers. Comparisons between the NMR prediction and the experimental data revealed that the regioisomer endo-1,6-NO2 predominated in the reaction. The in vitro antiparasitic activity of these compounds on intestinal unicellular parasites (Giardia intestinalis and Entamoeba histolytica) and a urogenital tract parasite (Trichomonas vaginalis) were tested. Compound 7 showed an IC50 of 3.95 μM and was 7 time more active against G. intestinalis than benznidazole. Compounds 7 and 8 showed 4 times more activity against T. vaginalis compared with benznidazole