Antibacterial activity of phenylpropanoids derived from cinnamic acid

In this work, we present antibacterial activity of a 22 phenylpropanoids derived from cinnamic acid, recently reported as antifungal agents by our group. Some of these compounds are commercial, others are natural products and some of them were obtained by synthesis. Antibacterial activity was determined in two stages. At first, a screening was made by an easy, economic and fast assay using a commercial lyophilized of Gram (+) bacteria. Compounds that showed activity at the screening were tested against Gram (+) and Gram (-) pathogens.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Acute toxicity study of commercial antifungal drugs using Poecilia reticulata

Commercial antifungal drugs possess important side effect; being toxicity the main limitation of such compounds. We report here a study of acute toxicity of four well-known commercial antifungal drugs; two of them used in human medicine (griseofulvine and miconazole) and the other two used against phytopatogens fungi (carbendazin and benomil). Toxic effects of these compounds were evaluated using an acute toxicity test on fish of the specie Poecilia reticulata.Colegio de Farmacéuticos de la Provincia de Buenos Aire