Reading Chinese Fortune Cookie: The Making of Chinese American Rhetoric

LuMing Mao offers an important discussion of the rhetoric of Chinese American speakers, which has wide implications for the teaching of writing in English and for our understanding of cross-cultural influences in discourse. Recent scholarship tends to explain such influences as contributing to language hybridity—an advance over the traditional deficit model. But Mao suggests that the hybridity approach is perhaps too arid or sanitized, missing rich nuances of mutual exchange, resistance, or even subversion. Through his concept of togetherness in difference, Mao suggests that speakers of hybrid discourse may not be attempting the standard (and failing), but instead may be deliberately importing cultural material to create a distance between themselves and the standard. This practice, over time, becomes a process that transforms English, enriching and enlarging it through the infusion of non-Western discourse features, subverting power structures, and even providing unique humorous touches. Of interest to scholars in composition, cultural studies, and linguistics as well, Reading Chinese Fortune Cookie leads in an important new direction for both our understanding and our teaching of English.https://digitalcommons.usu.edu/usupress_pubs/1158/thumbnail.jp

Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways

Genistein is a major isoflavonoid in dietary soybean, commonly consumed in Asia. Genistein exerts inhibitory effects on the proliferation of various cancer cells and plays an important role in cancer prevention. However, the molecular and cellular mechanisms of genistein on human ovarian cancer cells are still little known. We show that exposure of human ovarian cancer HO-8910 cells to genistein induces DNA damage, and triggers G2/M phase arrest and apoptosis. Furthermore, we also found that checkpoint proteins ATM and ATR are phosphorylated and activated in the cells treated with genistein. It is also shown that genistein increases the phosphorylation and activation of Chk1 and Chk2, which results in the phosphorylation and inactivation of phosphatases Cdc25C and Cdc25A, and thereby the phosphorylation and inactivation of Cdc2 which arrests cells in G2/M phase. Moreover, genistein enhances the phosphorylation and activation of p53, while decreases the ratio of Bcl-2/Bax and Bcl-xL/Bax and the level of phosphorylated Akt, which result in cells undergoing apoptosis. These results demonstrate that genistein-activated ATM-Chk2-Cdc25 and ATR-Chk1-Cdc25 DNA damage checkpoint pathways can arrest ovarian cancer cells in G2/M phase, and induce apoptosis while the cellular DNA damage is too serious to be repaired. Thus, the antiproliferative, DNA damage-inducing and pro-apoptotic activities of genistein are probably responsible for its genotoxic effects on human ovarian cancer HO-8910 cells. (C) 2009 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.National Natural Science Foundation of China [30400239, 30570935, 30871242]; Program for New Century Excellent Talents in Xiamen Universit