Leak location based on PDS-VMD of leakage-induced vibration signal under low SNR in water-supply pipelines

Leak location in water-supply pipelines is of great significance in order to preserve water resources and reduce economic losses. Cross-correlation (CC) based leak location is a popular and effective method in water-supply pipelines (WSP). However, with a decrease of signal to noise ratio (SNR), the errors of time-delay estimation (TDE) based on CC will become larger making it almost impossible to determine a leakage position. Hence, this work proposes leak location based on a combination of phase difference spectrum and variational mode decomposition (PDS-VMD) of leakage-induced vibration signal under low SNR for WSP. Firstly, the leakage-induced vibration signal is decomposed into several intrinsic mode functions (IMFs) by VMD, where the characteristic frequency band is determined by PDS of cross spectrum of two leakage signals. Then, the energy ratio of leakage signal in characteristic frequency band serves as a guideline to select effective IMF components from the decomposed IMFs. Finally, the selective IMFs are reconstituted into a new signal which can be used to determine a leak position using CC based TDE. In order to verify the effectiveness of the proposed leak location algorithm, the method based on PDS-VMD is compared with that using CC, combination of CC coefficient and VMD (CCC-VMD) using both simulation and experiment. The simulation and experimental results demonstrate that the proposed PDS-VMD method is more suitable for leak location in WSP, which provides immunity to both broadband and narrow band noise under low SNR. © 2020 IEEE

PCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women:a prospective cohort study

BackgroundImplementation of high-risk human papillomavirus (hrHPV) screening has greatly reduced the incidence and mortality of cervical cancer. However, a triage strategy that is effective, noninvasive, and independent from the subjective interpretation of pathologists is urgently required to decrease unnecessary colposcopy referrals in hrHPV-positive women.MethodsA total of 3251 hrHPV-positive women aged 30–82 years (median = 41 years) from International Peace Maternity and Child Health Hospital were included in the training set (n = 2116) and the validation set (n = 1135) to establish Cervical cancer Methylation (CerMe) detection. The performance of CerMe as a triage for hrHPV-positive women was evaluated.ResultsCerMe detection efficiently distinguished cervical intraepithelial neoplasia grade 2 or worse (CIN2 +) from cervical intraepithelial neoplasia grade 1 or normal (CIN1 −) women with excellent sensitivity of 82.4% (95% CI = 72.6 ~ 89.8%) and specificity of 91.1% (95% CI = 89.2 ~ 92.7%). Importantly, CerMe showed improved specificity (92.1% vs. 74.9%) in other 12 hrHPV type-positive women as well as superior sensitivity (80.8% vs. 61.5%) and specificity (88.9% vs. 75.3%) in HPV16/18 type-positive women compared with cytology testing. CerMe performed well in the triage of hrHPV-positive women with ASC-US (sensitivity = 74.4%, specificity = 87.5%) or LSIL cytology (sensitivity = 84.4%, specificity = 83.9%).ConclusionsPCDHGB7 hypermethylation-based CerMe detection can be used as a triage strategy for hrHPV-positive women to reduce unnecessary over-referrals.Trial registrationChiCTR2100048972. Registered on 19 July 2021.<br/