心拍変動のカオス解析と神経内臓統合モデルに基づく仮説の実験的検証

京都大学新制・課程博士博士(情報学)甲第24742号情博第830号新制||情||139(附属図書館)京都大学大学院情報学研究科数理工学専攻(主査)教授 梅野 健, 教授 太田 快人, 准教授 辻本 諭学位規則第4条第1項該当Doctor of InformaticsKyoto UniversityDFA

An extension of the entropic chaos degree and its positive effect

The Lyapunov exponent is used to quantify the chaos of a dynamical system, by characterizing the exponential sensitivity of an initial point on the dynamical system. However, we cannot directly compute the Lyapunov exponent for a dynamical system without its dynamical equation, although some estimation methods do exist. Information dynamics introduces the entropic chaos degree to measure the strength of chaos of the dynamical system. The entropic chaos degree can be used to compute the strength of chaos with a practical time series. It may seem like a kind of fnite space Kolmogorov-Sinai entropy, which then indicates the relation between the entropic chaos degree and the Lyapunov exponent. In this paper, we attempt to extend the defnition of the entropic chaos degree on a d-dimensional Euclidean space to improve the ability to measure the stength of chaos of the dynamical system and show several relations between the extended entropic chaos degree and the Lyapunov exponen

RRI dataset for comparative analysis of heart rate variability at rest, under physical load, and during brain tasks

Experimental data measuring RRI during sitting, standing, and brain tasks.1.

A versatile pathway to end-functionalized cellulose ethers for click chemistry applications

This paper describes a versatile pathway to heterobifunctional/telechelic cellulose ethers, such as tri-O-methyl cellulosyl azide and propargyl tri-O-methyl celluloside, having one free C-4 hydroxyl group attached to the glucosyl residue at the non-reducing end for the use in Huisgen 1, 3-dipolar cycloaddition and copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The one-step end-functionalization of cellulose ethers for molecular rod synthesis involves the introduction of two reactive groups at both ends of the cellulose molecule, and can afford linear triblock copolymers via CuAAC and further reactions. We were able to tailor the degree of polymerization of end-functionalized cellulose ethers with controlled amounts of a Lewis acid, namely SnCl4. Chemical structures of the above cellulose ethers and the reaction conditions for controlling molecular length are discussed

Objectively measured sedentary time and diabetes mellitus in a general Japanese population: The Hisayama Study

Abstract Aims/Introduction The present study aimed to examine cross‐sectional associations between objectively measured sedentary time and the prevalence of diabetes mellitus in a general Japanese population, and to elucidate possible mediating roles of diet, obesity and insulin resistance in this relationship. Materials and Methods A total of 1,758 community‐dwelling individuals aged 40–79 years wore an accelerometer for ≥7 days and underwent a comprehensive health examination in 2012. Diabetes mellitus was diagnosed by a 75‐g oral glucose tolerance test. The associations of sedentary time with the presence of diabetes mellitus and the levels of the homeostasis model assessment of insulin resistance were estimated by logistic and linear regression models. Results After adjustment for demographic and lifestyle factors including moderate‐to‐vigorous physical activity, participants who spent ≥10 h in sedentary time had a significantly higher odds ratio of the presence of diabetes than those who spent <6 h in sedentary time (odds ratio 1.84, 95% confidence interval 1.02–3.31). This significant association remained after adjusting for overall and central obesity (as measured by body mass index and waist circumference), but weakened after adjusting for dietary energy intake or homeostasis model assessment of insulin resistance. Sedentary time was positively associated with homeostasis model assessment of insulin resistance levels among non‐diabetic participants after adjusted for obesity or energy intake (P for trend <0.01). Conclusions Longer sedentary time was associated with a higher prevalence of diabetes mellitus in a general Japanese population. Insulin resistance appeared to be mainly involved in this association. These results highlight the importance of public health strategies targeting reductions in sedentary time for the primary prevention of diabetes mellitus