Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Effect of algal ration and substitution of algae by manipulated yeast diets on the growth of juvenile <i>Mercenaria mercenaria</i>

The development of a cost-effective algal substitute would greatly reduce the operating costs of bivalve hatcheries. Previous work has resulted in the development of a yeast diet with improved digestibility and nutritional composition. The use of this yeast product as a partial algal substitute for the culture of juvenile hard clams Mercenaria mercenaria was investigated in a series of growth experiments. Juveniles of the hard clam (1 mg live weight) were batch cultured in a 1 8 1 recirculating system for 2 or 3 weeks. The optimal weight-specific daily ration for a mixture (50/50 on dry weight basis) of Isochrysis galbana (clone T-Iso) and Chaetoceros gracilis was found to be 1.5 to 2% dry weight per wet weight of seed. Replacing 50% of the algal ration by yeast did not result in a significant decrease in growth rate relative to the algal-fed controls. The substitution of 80% of the algal diet resulted in growth rates reaching 90% compared with those obtained for the algal-fed controls. The incorporation in the yeast diet of fat-soluble vitamins, rice starch, or an extract from macro-algae did not improve its nutritional value. However, the addition of kaolin occasionally resulted in a significantly higher growth rate. The present results are compared with previous reports on the use of yeasts for nursery rearing of bivalves

Effect of lipid supplementation on growth, survival and fatty acid composition of bivalve larvae

Lipids, particularly triglycerides, play an important role in early life stages of bivalves as a source of energy and essential fatty acids. Ingestion and incorporation of the fatty acids supplied through lipid emulsions were verified analytically for larval oysters Ostrea edulis. Changes of the fatty acid composition, in particular of (n-3) highly unsaturated fatty acids (n-3 HUFA), were demonstrated in total lipids, polar lipids and triglycerides of oyster larvae fed the lipid emulsions as a supplement to Isochrysis galbana (clone T-Iso), and were dependent on the level and proportion of (n-3) HUFA present in the emulsion. Preliminary culture trials with Mercenaria mercenaria showed better growth and survival throughout metamorphosis for larvae receiving a 50% (of algal dry weight) DHA-rich supplement compared to the controls fed solely on Isochrysis galbana (Clone T-Iso). Supplementation of lipid emulsions that are rich in essential fatty acids may improve or standardize dietary supply of lipids and fatty acids in hatchery production of bivalve larvae

Lorsque l’enfant refuse le don de moelle osseuse

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