2,333 research outputs found
A SPH solver for simulating paramagnetic solid fluid interaction in the presence of an external magnetic field
Acknowledgment The first two authors wish to express their sincerest thanks to Iran National Science Foundation (INSF) for supporting this work under Contract Number 92021291.Peer reviewedPostprin
Non-linear stress response of non-gap-spanning magnetic chains suspended in a Newtonian fluid under oscillatory shear test : A direct numerical simulation
The corresponding author wishes to express his sincerest thanks to the Iran National Science Foundation (INSF) for supporting this work under Contract Number 92021291.Peer reviewedPostprintPublisher PD
Significance of the VELACS Project to the Solution of Boundary Value Problems in Geotechnical Engineering
The VELACS project was conducted in order to improve existing methods for the analysis of the consequences of soil liquefaction. The project showed that centrifuge studies are repeatable only under carefully controlled conditions. Most procedures were able to predict the onset of liquefaction in contractive soils, but only effective stress based fully coupled nonlinear procedures were able to predict deformations due to liquefaction· None of the currently available procedures could simulate the behavior of dilative soils adequately. Problems were attributed to improper constitutive model implementation and inadequate calibration. An example to evaluate the behavior of a flow slide observed in a dynamic centrifuge test is presented. Numerical simulations of deformations with a finite deformation formulation showed that the main core of the embankment remained stable after shaking. This is in agreement with the observed behavior
YAP contributes to DNA methylation remodeling upon mouse embryonic stem cell differentiation
The Yes-associated protein (YAP), one of the major effectors of the Hippo pathway together with its related protein WW-domain-containing transcription regulator 1 (WWTR1; also known as TAZ), mediates a range of cellular processes from proliferation and death to morphogenesis. YAP and WW-domain-containing transcription regulator 1 (WWTR1; also known as TAZ) regulate a large number of target genes, acting as coactivators of DNA-binding transcription factors or as negative regulators of transcription by interacting with the nucleosome remodeling and histone deacetylase complexes. YAP is expressed in self-renewing embryonic stem cells (ESCs), although it is still debated whether it plays any crucial roles in the control of either stemness or differentiation. Here we show that the transient downregulation of YAP in mouse ESCs perturbs cellular homeostasis, leading to the inability to differentiate properly. Bisulfite genomic sequencing revealed that this transient knockdown caused a genome-wide alteration of the DNA methylation remodeling that takes place during the early steps of differentiation, suggesting that the phenotype we observed might be due to the dysregulation of some of the mechanisms involved in regulation of ESC exit from pluripotency. By gene expression analysis, we identified two molecules that could have a role in the altered genome-wide methylation profile: the long noncoding RNA ephemeron, whose rapid upregulation is crucial for the transition of ESCs into epiblast, and the methyltransferase-like protein Dnmt3l, which, during the embryo development, cooperates with Dnmt3a and Dnmt3b to contribute to the de novo DNA methylation that governs early steps of ESC differentiation. These data suggest a new role for YAP in the governance of the epigenetic dynamics of exit from pluripotency
Polyphenol-mediated autophagy in cancer: Evidence of in vitro and in vivo studies
One of the hallmarks of cellular transformation is the altered mechanism of cell death. There are three main types of cell death, characterized by different morphological and biochemical features, namely apoptosis (type I), autophagic cell death (type II) and necrosis (type III). Autophagy, or self-eating, is a tightly regulated process involved in stress responses, and it is a lysosomal degradation process. The role of autophagy in cancer is controversial and has been associated with both the induction and the inhibition of tumor growth. Autophagy can exert tumor suppression through the degradation of oncogenic proteins, suppression of inflammation, chronic tissue damage and ultimately by preventing mutations and genetic instability. On the other hand, tumor cells activate autophagy for survival in cellular stress conditions. Thus, autophagy modulation could represent a promising therapeutic strategy for cancer. Several studies have shown that polyphenols, natural compounds found in foods and beverages of plant origin, can efficiently modulate autophagy in several types of cancer. In this review, we summarize the current knowledge on the effects of polyphenols on autophagy, highlighting the conceptual benefits or drawbacks and subtle cell-specific effects of polyphenols for envisioning future therapies employing polyphenols as chemoadjuvants
Centrality dependence of the expansion dynamics in Pb-Pb collisions at 158 A GeV/c
Two-particle correlation functions of negatively charged hadrons from Pb-Pb
collisions at 158 GeV/c per nucleon have been measured by the WA97 experiment
at the CERN SPS. A Coulomb correction procedure that assumes an expanding
source has been implemented. Within the framework of an expanding thermalized
source model the size and dynamical state of the collision fireball at
freeze-out have been reconstructed as a function of the centrality of the
collision. Less central collisions exhibit a different dynamics than central
ones: both transverse and longitudinal expansion velocities are slower, the
expansion duration is shorter and the system freezes out showing smaller
dimensions and higher temperature.Comment: 22 pages, 11 figures, Te
Strangeness Content in the Nucleon
I review recent studies of strangeness content in the nucleon pertaining to
the flavor-singlet , the matrix element and the strangeness
electric and magnetic form factors and , based on
lattice QCD calculations. I shall also discuss the relevance of incorporating
the strangeness content in nuclei in regard to strange baryon-antibaryon
productions from proton-nucleus and nucleus-nucleus collisions at SPS and RHIC
energies.Comment: 11 pages, 4 figures, Invited talk at V Int. Conf. on Strangeness in
Quark Matter, Berkeley, CA, July 20--25, 200
Performance of ALICE pixel prototypes in high energy beams
The two innermost layers of the ALICE inner tracking system are instrumented
with silicon pixel detectors. Single chip assembly prototypes of the ALICE
pixels have been tested in high energy particle beams at the CERN SPS.
Detection efficiency and spatial precision have been studied as a function of
the threshold and the track incidence angle. The experimental method, data
analysis and main results are presented.Comment: 10 pages, 9 figures, contribution to PIX2005 Workshop, Bonn
(Germany), 5-8 September 200
Production of H and H with the (K,) reaction
The production of neutron rich -hypernuclei via the
(,) reaction has been studied using data collected with the
FINUDA spectrometer at the DANE -factory (LNF). The analysis of the
inclusive momentum spectra is presented and an upper limit for the
production of H and H from Li and Li, is
assessed for the first time.Comment: 11 pages, 3 figures. Accepted for publication in PL
A study of the proton spectra following the capture of in Li and C with FINUDA
Momenta spectra of protons emitted following the capture of in Li
and C have been measured with 1% resolution. The C spectrum is
smooth whereas for Li a well defined peak appears at about 500 MeV/. The
first observation of a structure in this region was identified as a strange
tribaryon or, possibly, a -nuclear state. The peak is correlated with a
coming from decay in flight, selected by setting momenta
larger than 275 MeV/. The could be produced, together with a 500
MeV/ proton, by the capture of a in a deuteron-cluster substructure of
the Li nucleus. The capture rate for such a reaction is (1.62\pm
0.23_{stat} ^{+0.71}_{-0.44}(sys))%/K^-_{stop}, in agreement with the existing
observations on He targets and with the hypothesis that the Li nucleus
can be interpreted as a cluster.Comment: 21 pages, 10 figures. Accepted for publication in NP
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