Research on Modified Hybrid Frequency Modulation Technology of Type-III Asymmetric CHB Multilevel Inverters

Asymmetric Cascaded H-bridge (ACHB) level inverters can output more voltage waveforms with fewer cascaded units while ensuring the quality of output voltage waveforms, so they have attracted more and more attention. Taking the topology of Type-III asymmetric CHB multilevel inverters as the research object, a Modified Hybrid Frequency Pulse Width Modulation (MHF-PWM) strategy is proposed in this paper. This modulation strategy overcomes the local overshoot of low-voltage unit in the presence of traditional Hybrid Frequency Pulse Width Modulation (HF-PWM), thus completely eliminating the low frequency harmonics in the output voltage waveform of Type-III ACHB nine-level inverters, and the Total Harmonic Distortion (THD) of output line voltage of the modulation strategy is lower than that of PS-PWM strategy in the whole modulation degree, which effectively improves the quality waveform of the output line voltage. At the same time, the strategy can also improve the problems of current backflow and energy feedback caused by the high-voltage unit pouring current to the low-voltage unit, thereby reducing the imbalance of the output power of the high-voltage and low-voltage units. Finally, the Matlab/Simulink simulation model and experimental platform are established to verify the validity and practicality of the modulation strategy

Hedgehog Signaling Activation in Hepatic Stellate Cells Promotes Angiogenesis and Vascular Mimicry in Hepatocellular Carcinoma

<p>Previous studies have established that hedgehog (Hh) signaling mediates tumor-stroma interaction and promotes hepatocellular carcinoma progression. Here, we demonstrated that activation of Hh signaling in hepatic stellate cell (HSC) line LX-2 by Huh-7-derived sonic Hh led to increased secretion of angiogenic factors and promoted angiogenesis in vitro. The activated LX-2 also enhanced vascular mimicry of hepatoma cells. Furthermore, co-injection of Huh-7 and LX-2 significantly accelerated tumor growth with enhanced angiogenesis compared with Huh-7 alone, which could be partly abrogated by Hh signaling inhibitor. Collectively, our data showed that paracrine Hh signaling mediated pro-angiogenic function of HSC and enhanced hepatoma growth.</p