Genotypes and Subtypes of Hepatitis B Virus Isolates in the Territory of Siberia

Identified are the occurrence, serotypic and genotypic variations of Hepatitis B virus isolates (HBV) among the Novosibirsk region inhabitants (n=2000), native population of the Alarsk District of the Irkutsk Region (n=487) and Shuryshkarsk Township of the Yamalo-Nenets Autonomous District (n=657). Occurrence rate of hepatitis В surface antigen (HBsAg) among different groups of the Novosibirsk Region population varied within the limits of 3,6-35,0 %. It was 8,2 % in Alarsk District, and 3,2 % in Shuryshkarsk Township. HBV isolates of D genotype (92-97 %) prevail among the population of Siberia; few are the cases of A (1,7 %) and C (1,2-8 %) genotypes. The identified varying occurrence of HBV sub-genotypes and HBsAg subtypes in two aboriginal groups of Siberia (D3 sub-genotype and ayw2 subtype - in the Alarsk District, D2 and ayw3 - in Shuryshkarsk Township) suggests the existence of, at least, two isolated HBV virus populations, circulating among different groups of Siberia native population

CLINICAL AND IMMUNOHISTOCHEMICAL STUDIES IN THE DIAGNOSIS OF UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN PATIENTS WITH CHOLELITHIASIS

There were examined 132 patients in the age of 29-77 years old. Morphological features of abnormal shape or position of gallbladder were detected at 26.9% of patients with undifferentiated connective tissue dysplasia, and this may contribute to the formation of gallstones

Immunological indicators at children with autism spectrum disorders

Presents the results of a study on indicators of immunity 96 in children aged 3 to 11 years with autism spectrum disorders. The study of immunity by flow cytopfuorometry showed the highest number of leukocytes in peripheral blood is typical for children with delays in language development and autistic behavior, and for patients with Kanner syndrome increase in the absolute number of T-cytotoxic and limfocitopodobnye NK cells that may be indicative of immune activation. Of the results of the study of humoral immunity showed that in children with atypical autism IgA is higher but does not exceed the reference values. The data obtained can expand understanding of the nature of autism spectrum disorders involving the immune system, to objectify the condition of the nervous system, and enable the development of pathogenetic approaches to the treatment.Представлены результаты исследования показателей иммунитета у 96 пациентов в возрасте от 3 до 11 лет с РАС. Изучение клеточного иммунитета показало наибольшее количество лейкоцитов в периферической крови у детей с задержками развития речи и аутистическим поведением, у пациентов с синдромом Каннера повышение абсолютного количества Т-цитотоксических и лимфоцитоподобных NK клеток, что может свидетельствовать об активации иммунитета. В показателях гуморального иммунитета у детей с атипичным аутизмом IgA выше, но не выходит за пределы референсных значений. Полученные данные могут расширить представления о природе расстройств аутистического спектра, участие иммунной системы в данных нарушениях, объективизировать состояние нервной системы и позволят разработать патогенетические подходы в терапии

Mammalian sex determination—insights from humans and mice

Disorders of sex development (DSD) are congenital conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. Many of the genes required for gonad development have been identified by analysis of DSD patients. However, the use of knockout and transgenic mouse strains have contributed enormously to the study of gonad gene function and interactions within the development network. Although the genetic basis of mammalian sex determination and differentiation has advanced considerably in recent years, a majority of 46,XY gonadal dysgenesis patients still cannot be provided with an accurate diagnosis. Some of these unexplained DSD cases may be due to mutations in novel DSD genes or genomic rearrangements affecting regulatory regions that lead to atypical gene expression. Here, we review our current knowledge of mammalian sex determination drawing on insights from human DSD patients and mouse models

Medical tactical and operational-surgical soluition in infected pancreonecrosis

The results of surgical treatment of 171 patients with infected pancreonecrosis. It was established that mini-invasive treatment under ultrasound gives the best results when pankreonekroticheskih abscesses and phlegmon containing predominantly liquid pus. In the presence of large seizures should perform cross-omento bursostomu

Interoperation of research of gastroduodenal transition after taking in of perforativ duodenal ulcer

In article results intraoperational researches sewed up perforation ulcers are described, the basic pathoanatomical structures above a stenosis parts of a duodenal gut and gastroduodenal transition are designated. The received data about pathomorphology sewed up ulcers testify to their huge morphological variety, necessity of an individual approach for surgical treatment sewed up perforation ulcers

VISCERAL MANIFESTATIONS UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN PATIENTS WITH CHOLELITHIASIS

The study included 132 patients with cholelithiasis (108 women and 24 men) aged 29 to 77 years. Mean age of patients 53,9 ± 12,8 years. In 63 (47,7%) patients with cholelithiasis clinical signs undifferentiated connective tissue dysplasia of varying severity. Of these, 34% of patients detected abnormality of the gastrointestinal tract. In 26,9% of patients with cholelithiasis diagnosed NDCTD anomalies identified various shapes and positions of the gallbladder