Pyrgi, l'area a nord del santuario. Nuovi dati dalle recenti campagne di scavo

The district North of Temple A, intermediate between the Monumental Sanctuary, the settlement and the harbour, played a fundamental role in the urbanistic development of the Etruscan site of Pyrgi. It includes the intersection between the terminal trait of the main road connecting Caere to the coastline and the large pebbled road leading towards the harbour, and different buildings erected along the latter track. Recent fieldwork (2011-2016) has shed light on the layout of the district and its progressive transformation, starting from the 7th century BC. Its peculiar function is proved by the many ritual actions performed to stress meaningful events, such as the deposition of a dissected dog for the foundation of a trapezoidal tower-building North of the pebbled road and the deposition of selected imported items (5 phoenician oil lamps, the gorgonic mask of a campanian antefix and ionian pottery shapes) inside the so called "Edificio porticato", erected at the intersection between the two roads. Extremely meaningful is the sequence of archaic decorated roofs (ionian, campanian and caeretan style) attested by several fragments of architectural terracottas, highlighting the fundamental role of Caere (and Pyrgi) in the reception/elaboration of architectural decorative systems, thanks to its strict cultural contacts with Latium and Campania/Cuma

Impact of Antiretroviral Therapy on the Risk of Recurrence in HIV-1 Infected Patients with Kaposi Sarcoma: A Multicenter Cohort Experience

Abstract Kaposi sarcoma (KS) remains a relevant malignancy in human immunodeficiency virus (HIV)-infected patients with a non-standardized management; despite past suggestions that ritonavir-boosted protease inhibitor (bPI)-based regimens could be preferable, no combination antiretroviral therapy (cART) regimen was demonstrated to outperform the others and the impact of new drugs, drug classes or paradigms was never investigated nor proven better than previous therapeutic regimes. In order to do this, we retrospectively collected data regarding HIV-infected patients with a diagnosis of KS last seen in six Italian centers after 1 January 2013. A total of 104 KS cases in 99 patients was analyzed for 945.34 patient-year follow-up (PYFU). Twenty-six patients had visceral localizations. Thirty-three patients were treated with chemotherapy, four with electrochemotherapy, and 12 with \u3b1-interferon (\u3b1-IFN). At censor, 22% received a bPI-based, 14% a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based, and 28% an integrase inhibitor (INI)-based standard cART, 24% a less drug regimen and 12% a mega-cART. Twelve recurrence episodes were observed in seven patients for an incidence of 1.27 per 100 PYFU. Two patients with no evidence of recurrence episodes died for other reasons. In our experience, KS recurrence episodes were infrequent. Despite the increasing use of new antiretroviral drug classes and new treatment paradigms, no excess of recurrence episodes was observed in patients receiving such cART regimens