11 research outputs found
EVALUATION OF A NEW CATHETER (ER-PT) SUITABLE FOR BOTH DIAGNOSTIC ERCP AND ENDOSCOPIC PAPILLOTOMY
VALUE OF SERUM ACUTE-PHASE REACTANT PROTEINS AND CARCINOEMBRYONIC ANTIGEN IN THE PREOPERATIVE STAGING OF COLORECTAL-CANCER - A MULTIVARIATE-ANALYSIS
Protein expression of bax, bcl-2, and p53 in patients with non-Hodgkin's gastric lymphoma: Prognostic significance
The biologic significance of bcl-2, bax, and p53 gene expression in
patients with non-Hodgkin’s gastric lymphoma is unknown. We examined the
prognostic value of these genes in 36 patients with gastric lymphoma
treated in our clinic between 1990 and 1995. Paraffin-embedded specimens
from 36 patients who underwent primary resection of the stomach for
gastric lymphoma were analyzed immunohistochemically for p53, bax, and
bcl-2 gene expression. Expression of bax was seen in 24 of 36 patients
(66.7%), p53 expression was found in 8 of 36 tumors (22.2%), and bcl-2
cytoplasmic staining was detected in 6 of 36 patients (16.7%). We
performed a univariate analysis to examine the possible correlation
between the expression of these genes and the survival of our patients.
Expression of bax protein proved to be a statistically significant
prognostic factor (p = 0.049). Protein expression of p53 and bcl-2 did
not statistically correlate with survival. In the bcl-2-negative (-)
patient group (30 patients). those who were bax-positive had a
statistically significant better survival than those who were
bax-negative (63.3% vs. 36.7%, p = 0.03). There was also a
statistically significant correlation between p53 expression and the
grade of the tumor (p = 0.0014). P53 protein expression increased along
with the grade. Expression of bax is a significant prognostic factor in
patients with gastric lymphoma. Its prognostic value increases
significantly when studied in bcl-2-negative patients: hut expression of
bax failed to be an independent prognostic factor. Expression of bcl-2
and p53 has no prognostic significance. Expression of p53 seems to
represent a marker for loss of differentiation