1,654 research outputs found
Novel Sex Cells and Evidence for Sex Pheromones in Diatoms
BACKGROUND: Diatoms belong to the stramenopiles, one of the largest groups of eukaryotes, which are primarily characterized by a presence of an anterior flagellum with tubular mastigonemes and usually a second, smooth flagellum. Based on cell wall morphology, diatoms have historically been divided into centrics and pennates, of which only the former have flagella and only on the sperm. Molecular phylogenies show the pennates to have evolved from among the centrics. However, the timing of flagellum loss--whether before the evolution of the pennate lineage or after--is unknown, because sexual reproduction has been so little studied in the 'araphid' basal pennate lineages, to which Pseudostaurosira belongs. METHODS/PRINCIPAL FINDING: Sexual reproduction of an araphid pennate, Pseudostaurosira trainorii, was studied with light microscopy (including time lapse observations and immunofluorescence staining observed under confocal scanning laser microscopy) and SEM. We show that the species produces motile male gametes. Motility is mostly associated with the extrusion and retrieval of microtubule-based 'threads', which are structures hitherto unknown in stramenopiles, their number varying from one to three per cell. We also report experimental evidence for sex pheromones that reciprocally stimulate sexualization of compatible clones and orientate motility of the male gametes after an initial 'random walk'. CONCLUSIONS/SIGNIFICANCE: The threads superficially resemble flagella, in that both are produced by male gametes and contain microtubules. However, one striking difference is that threads cannot beat or undulate and have no motility of their own, and they do not bear mastigonemes. Threads are sticky and catch and draw objects, including eggs. The motility conferred by the threads is probably crucial for sexual reproduction of P. trainorii, because this diatom is non-motile in its vegetative stage but obligately outbreeding. Our pheromone experiments are the first studies in which gametogenesis has been induced in diatoms by cell-free exudates, opening new possibilities for molecular 'dissection' of sexualization
Scattering and duality in the 2 dimensional OSP(2|2) Gross Neveu and sigma models
We write the thermodynamic Bethe ansatz for the massive OSp(2|2) Gross Neveu
and sigma models. We find evidence that the GN S matrix proposed by Bassi and
Leclair [12] is the correct one. We determine features of the sigma model S
matrix, which seem highly unconventional; we conjecture in particular a
relation between this sigma model and the complex sine-Gordon model at a
particular value of the coupling. We uncover an intriguing duality between the
OSp(2|2) GN (resp. sigma) model on the one hand, and the SO(4) sigma (resp. GN
model) on the other, somewhat generalizing to the massive case recent results
on OSp(4|2). Finally, we write the TBA for the (SUSY version of the) flow into
the random bond Ising model proposed by Cabra et al. [39], and conclude that
their S matrix cannot be correct.Comment: 41 pages, 27 figures. v2: minor revisio
The scalar gluonium correlator: large-beta_0 and beyond
The investigation of the scalar gluonium correlator is interesting because it
carries the quantum numbers of the vacuum and the relevant hadronic current is
related to the anomalous trace of the QCD energy-momentum tensor in the chiral
limit. After reviewing the purely perturbative corrections known up to
next-next-to-leading order, the behaviour of the correlator is studied to all
orders by means of the large-beta_0 approximation. Similar to the QCD Adler
function, the large-order behaviour is governed by the leading ultraviolet
renormalon pole. The structure of infrared renormalon poles, being related to
the operator product expansion are also discussed, as well as a low-energy
theorem for the correlator that provides a relation to the renormalisation
group invariant gluon condensate, and the vacuum matrix element of the trace of
the QCD energy-momentum tensor.Comment: 14 pages, references added, discussion of IR renormalon pole at u=3
extended, similar version to appear in JHE
Walk well:a randomised controlled trial of a walking intervention for adults with intellectual disabilities: study protocol
Background - Walking interventions have been shown to have a positive impact on physical activity (PA) levels, health and wellbeing for adult and older adult populations. There has been very little work carried out to explore the effectiveness of walking interventions for adults with intellectual disabilities. This paper will provide details of the Walk Well intervention, designed for adults with intellectual disabilities, and a randomised controlled trial (RCT) to test its effectiveness. Methods/design - This study will adopt a RCT design, with participants allocated to the walking intervention group or a waiting list control group. The intervention consists of three PA consultations (baseline, six weeks and 12 weeks) and an individualised 12 week walking programme. A range of measures will be completed by participants at baseline, post intervention (three months from baseline) and at follow up (three months post intervention and six months from baseline). All outcome measures will be collected by a researcher who will be blinded to the study groups. The primary outcome will be steps walked per day, measured using accelerometers. Secondary outcome measures will include time spent in PA per day (across various intensity levels), time spent in sedentary behaviour per day, quality of life, self-efficacy and anthropometric measures to monitor weight change. Discussion - Since there are currently no published RCTs of walking interventions for adults with intellectual disabilities, this RCT will examine if a walking intervention can successfully increase PA, health and wellbeing of adults with intellectual disabilities
Effects of abstinence on brain morphology in alcoholism: A MRI study
Chronic alcohol abuse leads to morphological changes of the brain. We investigated if these volumetric changes are reversible after a period of abstinence. For this reason 41 male and 15 female alcohol patients underwent MRI-scanning after in-patient detoxification (baseline) entering alcoholism treatment programs, and between 6 and 9 months later (follow-up), in a phase of convalescence. Additionally, 29 male and 16 female control subjects were examined. The MRI-scans were delineated and the resulting regions of interest, volumes of lateral ventricles and prefrontal lobes were expressed relatively to total brain volume. Compared to control subjects alcohol patients showed bilaterally decreased prefrontal lobes (11% reduction) and increased lateral ventricles (up to 42% enlargement). The extent of the ventricular increase was depending on patient’s additional psychiatric diagnosis, showing smaller lateral ventricles in patients with additional personality disorder. While at follow-up the size of prefrontal lobes remained unchanged, volumes of the lateral ventricles decreased (5–6% reduction) in alcohol patients with abstinence and improved drinking behavior, especially in patients that underwent only one detoxification. The extent of the ventricular enlargement correlated with the elevation of alcohol related laboratory measures (mean corpuscular volume, gamma-glutamyl transpeptidase). In conclusion this study confirms the hypothesis that alcoholism causes brain damages that are partially reversible. It should be analyzed in further studies with larger sample sizes, if complete brain regeneration is possible maintaining abstinence over a longer period
Sublittoral soft bottom communities and diversity of Mejillones Bay in northern Chile (Humboldt Current upwelling system)
The macrozoobenthos of Mejillones Bay (23°S; Humboldt Current) was quantitatively investigated over a 7-year period from austral summer 1995/1996 to winter 2002. About 78 van Veen grab samples taken at six stations (5, 10, 20 m depth) provided the basis for the analysis of the distribution of 60 species and 28 families of benthic invertebrates, as well as of their abundance and biomass. Mean abundance (2,119 individuals m-2) was in the same order compared to a previous investigation; mean biomass (966 g formalin wet mass m-2), however, exceeded prior estimations mainly due to the dominance of the bivalve Aulacomya ater. About 43% of the taxa inhabited the complete depth range. Mean taxonomic Shannon diversity (H', Log e) was 1.54 ± 0.58 with a maximum at 20 m (1.95 ± 0.33); evenness increased with depth. The fauna was numerically dominated by carnivorous gastropods, polychaetes and crustaceans (48%). About 15% of the species were suspensivorous, 13% sedimentivorous, 11% detritivorous, 7% omnivorous and 6% herbivorous. Cluster analyses showed a significant difference between the shallow and the deeper stations. Gammarid amphipods and the polychaete family Nephtyidae characterized the 5-mzone, the molluscs Aulacomya ater, Mitrella unifasciata and gammarids the intermediate zone, while the gastropod Nassarius gayi and the polychaete family Nereidae were most prominent at the deeper stations. The communities of the three depth zones did not appear to be limited by hypoxia during non-El Niño conditions. Therefore, no typical change in community structure occurred during El Niño 1997–1998, in contrast to what was observed for deeper faunal assemblages and hypoxic bays elsewhere in the coastal Humboldt Current system
New Solution for Neutrino Masses and Leptogenesis in Adjoint SU(5)
We investigate baryogenesis via leptogenesis and generation of neutrino
masses and mixings through the Type I plus Type III seesaw plus an one-loop
mechanism in the context of Renormalizable Adjoint SU(5) theory. One light
neutrino remains massless, because the contributions of three heavy Majorana
fermions \rho_0, \rho_3 and \rho_8 to the neutrino mass matrix are not linearly
independent. However none of these heavy fermions is decoupled from the
generation of neutrino masses. This opens a new range in parameter space for
successful leptogenesis, in particular, allows for inverted hierarchy of the
neutrino masses.Comment: 16 pages, 4 figures; references added and typos fixe
Merozoite surface protein-3α is a reliable marker for population genetic analysis of Plasmodium vivax
BACKGROUND: The knowledge on population structure of the parasite isolates has contributed greatly to understanding the dynamics of the disease transmission for designing and evaluating malaria vaccines as well as for drug applications. msp-1 and msp-3α genes have been used as a genetic marker in population studies of Plasmodium vivax isolates. In this study, msp-3α was compared and assessed with msp-1 marker in order to find whether msp-3α is a reliable genetic marker for P. vivax population studies. METHODS: This comparative study was designed and carried out as the first assessment of diversity in Pvmsp-3α gene by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in the 50 northern and 94 southern P. vivax isolates from Iran, which had been analysed before for msp-1 gene. RESULTS: Three allele size as, Type A (1.8 kb), Type B (1.5 kb) and Type C (1.2 kb) have been detected among both northern and southern isolates based on PCR results. Type C (70%) and Type A (68.7%) were the predominant fragments among northern and southern parasites, respectively. 99 distinct Pvmsp-3α fragments defined by the size were detected in the 94 southern samples by PCR analysis. However, no mixed genotype infections have been detected among northern isolates. Based on restriction pattern from digestion with Hha I and Alu I 12 and 49 distinct allelic variants have been detected among 50 northern and 94 southern isolates. However, based on msp-1 gene, 30 distinct variants identified in all 146-sequenced Iranian P. vivax isolate. CONCLUSION: The results suggested that PCR-RFLP on msp-3α gene is an adequate, applicable and easily used technique for molecular epidemiology studies of P. vivax isolates without the need for further sequencing analysis
Virtual Compton Scattering off a Spinless Target in AdS/QCD
We study the doubly virtual Compton scattering off a spinless target
within the Anti-de Sitter(AdS)/QCD formalism. We find
that the general structure allowed by the Lorentz invariance and gauge
invariance of the Compton amplitude is not easily reproduced with the standard
recipes of the AdS/QCD correspondence. In the soft-photon regime, where the
semi-classical approximation is supposed to apply best, we show that the
measurements of the electric and magnetic polarizabilities of a target like the
charged pion in real Compton scattering, can already serve as stringent tests.Comment: 21 pages, version to be published in JHEP
Implications of Flavor Dynamics for Fermion Triplet Leptogenesis
We analyze the importance of flavor effects in models in which leptogenesis
proceeds via the decay of Majorana electroweak triplets. We find that depending
on the relative strengths of gauge and Yukawa reactions the asymmetry can
be sizably enhanced, exceeding in some cases an order of magnitude level. We
also discuss the impact that such effects can have for TeV-scale triplets
showing that as long as the asymmetry is produced by the dynamics of the
lightest such triplet they are negligible, but open the possibility for
scenarios in which the asymmetry is generated above the TeV scale by heavier
states, possibly surviving the TeV triplet related washouts. We investigate
these cases and show how they can be disentangled at the LHC by using Majorana
triplet collider observables and, in the case of minimal type III see-saw
models even through lepton flavor violation observables.Comment: 22 pages, 9 figures, extended discussion on collider phenomenology,
references added. Version matches publication in JHE
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