Developing a Mobile Application‐Based Particle Image Velocimetry Tool for Enhanced Teaching and Learning in Fluid Mechanics: A Design‐Based Research Approach

A robust and intuitive understanding of fluid mechanics—the applied science of fluid motion—is foundational within many engineering disciplines, including aerospace, chemical, civil, mechanical, naval, and ocean engineering. In‐depth knowledge of fluid mechanics is critical to safe and economical design of engineering applications employed globally everyday, such as automobiles, aircraft, and sea craft, and to meeting global 21st century engineering challenges, such as developing renewable energy sources, providing access to clean water, managing the environmental nitrogen cycle, and improving urban infrastructure. Despite the fundamental nature of fluid mechanics within the broader undergraduate engineering curriculum, students often characterize courses in fluid mechanics as mathematically onerous, conceptually difficult, and aesthetically uninteresting; anecdotally, undergraduates may choose to opt‐out of fluids engineering‐related careers based on their early experiences in fluids courses. Therefore, the continued development of new frameworks for engineering instruction in fluid mechanics is needed. Toward that end, this paper introduces mobile instructional particle image velocimetry (mI‐PIV), a low‐cost, open‐source, mobile application‐based educational tool under development for smartphones and tablets running Android. The mobile application provides learners with both technological capability and guided instruction that enables them to visualize and experiment with authentic flow fields in real time. The mI‐PIV tool is designed to generate interest in and intuition about fluid flow and to improve understanding of mathematical concepts as they relate to fluid mechanics by providing opportunities for fluids‐related active engagement and discovery in both formal and informal learning contexts

The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review

Knee osteoarthritis (OA) is one of the leading causes of disability within the adult population. Current treatment options for OA of the knee include intra-articular (IA) hyaluronic acid (HA), a molecule found intrinsically within the knee joint that provides viscoelastic properties to the synovial fluid. A variety of mechanisms in which HA is thought to combat knee OA are reported in the current basic literature. We conducted a comprehensive literature search to identify currently available primary non-clinical basic science articles focussing on the mechanism of action of IA-HA treatment. Included articles were assessed and categorized based on the mechanism of action described within them. The key findings and conclusions from each included article were obtained and analyzed in aggregate with studies of the same categorical assignment. Chondroprotection was the most frequent mechanism reported within the included articles, followed by proteoglycan and glycosaminoglycan synthesis, anti-inflammatory, mechanical, subchondral, and analgesic actions. HA-cluster of differentiation 44 (CD44) receptor binding was the most frequently reported biological cause of the mechanisms presented. High molecular weight HA was seen to be superior to lower molecular weight HA products. HA derived through a biological fermentation process is also described as having favorable safety outcomes over avian-derived HA products. The non-clinical basic science literature provides evidence for numerous mechanisms in which HA acts on joint structures and function. These actions provide support for the purported clinical benefit of IA-HA in OA of the knee. Future research should not only focus on the pain relief provided by IA-HA treatment, but the disease modification properties that this treatment modality possesses as well