Lempel Ziv Welch data compression using associative processing as an enabling technology for real time application

Data compression is a term that refers to the reduction of data representation requirements either in storage and/or in transmission. A commonly used algorithm for compression is the Lempel-Ziv-Welch (LZW) method proposed by Terry A. Welch[l]. LZW is an adaptive, dictionary based, lossless algorithm. This provides for a general compression mechanism that is applicable to a broad range of inputs. Furthermore, the lossless nature of LZW implies that it is a reversible process which results in the original file/message being fully recoverable from compression. A variant of this algorithm is currently the foundation of the UNIX compress program. Additionally, LZW is one of the compression schemes defined in the TIFF standard[12], as well as in the CCITT V.42bis standard. One of the challenges in designing an efficient compression mechanism, such as LZW, which can be used in real time applications, is the speed of the search into the data dictionary. In this paper an Associative Processing implementation of the LZW algorithm is presented. This approach provides an efficient solution to this requirement. Additionally, it is shown that Associative Processing (ASP) allows for rapid and elegant development of the LZW algorithm that will generally outperform standard approaches in complexity, readability, and performance

Oxidative stress in term small for gestational age neonates born to undernourished mothers: a case control study

BACKGROUND: The objective of this study was to assess the status of oxidative stress in term small for gestational age (SGA) newborn infants born to undernourished mothers by estimating levels of erythrocyte superoxide dismutase (SOD), catalase, reduced glutathione, and serum malondialdehyde (MDA) in cord blood and comparing them to healthy appropriate for gestational age (AGA) controls. This was done in a case control design at a tertiary level teaching hospital. METHODS: We included 20 singleton healthy SGA newborn infants born between 38–40 weeks to undernourished mothers with a) post-pregnancy weight < 50 kg or height < 145 cm AND b) hemoglobin < 8.0 g/dL or serum albumin < 2.5 g/dL. An equal number of age and sex matched AGA newborn infants born to healthy mothers served as Controls. Mothers with other risk factors and newborns with complications during delivery or immediate newborn period were excluded. MDA, SOD, catalase and reduced glutathione were measured in the cord blood of all neonates and compared between the groups (unpaired t test); levels were also correlated to maternal weight, height, hemoglobin, and albumin by both univariate (pearsonian correlation) and multivariate (multiple regression) analysis. RESULTS: The activity of MDA was increased (5.33 ± 0.72 vs 2.55 ± 0.22 nmol/mL; P < 0.0001) while levels of superoxide dismutase (493.6 ± 54.9 vs. 786.8 ± 79.1 U/g Hb; P < 0.0001), catalase (1.48 ± 0.24 vs. 2.31 ± 0.20 U/g Hb; P < 0.0001) and reduced glutathione (2.84 ± 0.37 vs 6.42 ± 0.23 Umol/g Hb, P < 0.0001) were decreased in term SGA born to undernourished mothers as compared to term AGA born to healthy mothers. On univariate analysis, all the markers of oxidative stress correlated significantly with maternal parameters (P < 0.005). On multivariate analysis, maternal albumin and hemoglobin accounted for maximum correlation with the markers of oxidative stress. CONCLUSIONS: Intrauterine malnutrition is associated with significant oxidative stress in small for gestational age neonates born at term to malnourished mothers

Rare association of celiac disease with congenital heart disease

Celiac disease (CD) is an autoimmune enteropathy caused by exposure to dietary gluten in genetically predisposed individuals. CD is a multisystem disease involving gastrointestinal, hepatobiliary, nervous, hematologic, and cardiovascular systems. Few associations of congenital heart disease have been reported with CD. We report a case of an 8-year-old female, who was presented to the hospital with severe anemia and undernutrition. She had severe pallor, clubbing, hepatomegaly, and a Grade Ш systolic ejection murmur. Echocardiography revealed a large ostium secundum type of atrial septal defect and patent ductus arteriosus. The increased levels of serum IgA anti-tissue transglutaminase (anti-TTG) antibody have arisen suspicion of CD, which was confirmed after the histopathological study of the duodenal biopsy. We are reporting this case to highlight the rare association of the CD with congenital heart disease

Visual impairments in children with cerebral palsy

Background: Visual impairments are associated with cerebral palsy (CP). They enhance functional limitations in children with CP. Objective: The objective of the study was to determine the types of visual impairments in children with CP, and thus the importance of early evaluation and intervention to improve the quality of life. Materials and Methods: Children with CP (n=775) attending the child development clinic from 2012 to 2017 were included in the study. Thorough antenatal, natal, postnatal, and developmental history were recorded. Complete demographic data, anthropometry and general physical, and neurological examination findings were recorded. All patients were advised neuroimaging (computed tomography/magnetic resonance imaging) and hearing and ophthalmological assessment. Results: Of the 775 patients, 270 (34.8%) patients had squint (including convergent and divergent). Detailed fundoscopic and visual evoked potentials (VEP) examination was done in 382 patients. Non-apparent abnormalities (VEP and fundus changes) were seen in 121 patients (31.7%) among 382 tested. Of those 121 patients, VEP changes and fundus changes were seen in 62 and 41 patients, respectively. Refractive errors were detected in 25 patients. Of the total patients assessed for ophthalmological ailments, 129 (33.7%) patients were completely normal. Conclusion: Visual impairments are associated in large percentage of CP patients. Early evaluation and intervention are emphasized to improve the quality of life in these patients

Multivariate analysis as a method to understand variability in a complex excipient, and its contribution to formulation performance

A key part of the Risk Assessment of excipients is to understand how raw material variability could (or does) contribute to differences in performance of the drug product. Here we demonstrate an approach which achieves the necessary understanding for a complex, functional, excipient. Multivariate analysis (MVA) of the certificates of analysis of an ethylcellulose aqueous dispersion (Surelease) formulation revealed low overall variability of the properties of the systems. Review of the scores plot to highlight batches manufactured using the same ethylcellulose raw material in the formulation, indicated that these batches tend to be more closely related than other randomly selected batches. This variability could result in potential differences in the quality of drug product lots made from these batches. Manufacture of a model drug product from Surelease batches coated using different lots of starting material revealed small differences in the release of a model drug, which could be detected by certain model dependent dissolution modelling techniques, but they were not observed when using model-independent techniques. This illustrates that the techniques are suitable for detecting and understanding excipient variability, but that, in this case, the product was still robust

Gut obstruction sequel to corrosive poisoning: Role of early endoscopy

Background: Ingestion of corrosive substances remains a common problem in our country as they are easily available for household use. Case Characteristics: We report two cases of gut obstruction in children as a sequel to acid ingestion. Intervention: Surgery and dilatations were performed in Case 1 and 2 respectively. Message: Early Endoscopy is of crucial importance in management and prognosis

Epidemiological trends of tetanus from East Delhi, India: A hospital-based study

Objective: To study the demographic profile, prognostic indicators, and mortality of tetanus patients and treatment outcomes following intramuscular anti-tetanus immunoglobulin (ATG) alone or combined intrathecal and intramuscular ATG. Design: Retrospective study. Setting: Inpatients from a tertiary care hospital.Subjects: One hundred children under 12 years of age diagnosed with tetanus and admitted from January 2003 to December 2007 were included in the study. Methods: Case records of patients with neonatal tetanus (n = 30) and post-neonatal tetanus (n = 70) were evaluated retrospectively. The diagnosis of tetanus was based on World Health Organization (WHO) criteria. The outcomes of patients treated with either intramuscular ATG or both intrathecal and intramuscular ATG were separately compared in the neonatal and post-neonatal groups. Results: Our study revealed difficulty in feeding, trismus, spasms, rigidity, and opisthotonus posturing as the predominant clinical manifestations. The survival rate for children receiving tetanus immunoglobulin by the dual route was significantly higher than for children receiving the immunoglobulin via the intramuscular route. Seizures and tremors were poor prognostic factors associated with tetanus. Keywords: Tetanus, Immunoglobulin, Eliminatio

Predictors of mortality among the neonates transported to referral centre in Delhi, India

A descriptive study was conducted with an objective to determine the predictors of mortality among referred neonates and to ascertain their transport characteristics. A total of 300 consecutive neonates who were transferred to the centre were enrolled in the study. Following information were recorded: maternal details, birth details, interventions before transportation, details of transportation and neonatal condition at arrival. Detailed clinical assessment and management was done as per standard neonatal protocols. Birth weight 1 hour (OR 5.58; 95% CI: 1.41-22.01, P=0.01) were found to be significant predictors for mortality among the transported neonate. Transport characteristics reflect road transport with limited utility of ambulances and lack of trained health personal. Hence to conclude, extreme low birth weight and prolonged transportation time were found to be significant predictors of neonatal mortality among the transported neonate