Improved Least-Square DV-Hop Algorithm for Localization in large scale wireless sensor network

Certain applications of wireless sensor networks require that the sensor nodes should be aware of their position relative to the sensor environment. Generally in the applications of positioning in the internet of things (IoT), there is a deficiency of localization precision and concrete results. It is really important to maintain high-efficient localization schemes for the Internet of things, especially for wireless sensor networks. For that, an improved DV-hop algorithm is proposed in this paper to move for more accurate results based on the least square method. Therefore, the weight coefficient is calculated between an anchor node and the other anchor nodes using the mean square method. Then, this weighting coefficient, the hop size, will be applied between the unknown nodes and the anchor nodes in order to determine the distances. The computed hop-size average significantly enhances the positioning accuracy which is approved by the experiments that explain how suitable this improved Last- Square DV-hop Algorithm is for localization in WSN

Spectral discretization of the Navier–Stokes equations coupled with the heat equation

We consider the spectral discretization of the Navier–Stokes equations coupled with the heat equation where the viscosity depends on the temperature, with boundary conditions which involve the velocity and the temperature. This problem admits a variational formulation with three independent unknowns, the velocity, the pressure and the temperature. We prove optimal error estimates and present some numerical experiments which confirm the validity of the discretization

Improved 3D localization algorithm for large scale wireless sensor networks

As localization represents the main core of various wireless sensor network applications, several localization algorithms have been suggested in wireless sensor network research. In this article, we put forward an iterative bounding box algorithm enhanced by a Kalman filter to refine the unknown node’s estimated position. In fact, several research efforts are currently in progress to extend the 2D positioning algorithm in WSNs to 3D that reflects reality and the most practical applications. Subsequently, we replace a large number of GPS-equipped anchors with a single mobile anchor. In our studies, we consider the type of range-free sensor network exploiting the wireless sensors connectivity. We assess the performance of our algorithm using exhaustive experiments on several isotropic and anisotropic topologies. Our proposed algorithm can fulfill the joint goals of algorithm transparency and accuracy for various scenarios by evaluating parameters such as localization accuracy whilst changing other simulation parameters such as the effect of communication range, mobile anchor node position and sensor node deployment topology. It has been proven by the results of the experiments that the proposed algorithm effectively reduces the location error without requiring more equipment or increasing the communication cost

A Novel Homozygous Nonsense HYDIN Gene Mutation p.(Arg951*) in Primary Ciliary Dyskinesia

International audienceNo abstract availabl

High Nasal Nitric Oxide, Cilia Analyses, and Genotypes in a Retrospective Cohort of Children with Primary Ciliary Dyskinesia

International audienceRationale: Although children with primary ciliary dyskinesia (PCD) typically have low nasal nitric oxide (nNO), some children with indisputable PCD may have unexplained high nNO concentrations. Objectives: To look for relationships between nNO measures and genetic findings (and cilia motility or ultrastructure when available) in children with PCD with known genotypes. Methods: We retrospectively studied 73 children with PCD (median age, 9.5 [range, 2.1-18.2] yr). nNO was the mean value of a plateau reached while the velum was closed (nNO-VC; threshold, 77 nl ⋅ min-1) or was calculated as the average of five peaks obtained during tidal breathing (threshold, 40 nl ⋅ min-1). Ciliary beat was classified as either motile (including dyskinetic pattern) or immotile, depending on whether motility was present or absent in all cilia, or as a mixture of motile and immotile cilia. Genotypes were classified as pathogenic mutations in genes known to be associated with high nNO (mild genotype), biallelic truncating mutations in other genes (severe mutations), or putative hypomorphic pathogenic mutations (missense, single amino acid deletion, or moderate splicing mutations) in at least one allele believed to be possibly associated with residual production of a functional protein. Results: nNO was above the discriminant threshold in 16 of 73 (21.9%) children (11 nNO-VC and 5 nNO during tidal breathing). High nNO was less frequent in children with severe mutations (2 of 42) than in those with mild genotypes (7 of 10) or at least one hypomorphic mutation (7 of 21) (P < 0.0001). Median (interquartile range) nNO-VC values (n = 60) were significantly different in the three genotype groups: severe mutations, 18 (10-26) nl ⋅ min-1 (n = 36); possible residual functional protein production (putative hypomorphic mutations), 23 (16-68) nl ⋅ min-1 (n = 17); and mild genotypes, 139 (57-216) nl ⋅ min-1 (n = 7) (P = 0.0002). The higher the cilia motility, the higher the nNO-VC (16 [10-23], 23 [17-56], and 78 [45-93] nl ⋅ min-1 in patients with immotile, dyskinetic motile and immotile, and dyskinetic motile cilia, respectively; P < 0.0001), while nNO values were scattered across different ultrastructure defects (P = 0.07). Conclusions: In children with PCD, high nNO values were linked not only to specific genes but also to potentially hypomorphic mutations in other genes (with possible functional protein production). nNO values increased with the proportion of motile cilia

Development and first results of the BEAT PCD international Primary Ciliary Dyskinesia gene variant database: CiliaVar

International audienceAim: To establish an online open database registering mutations and specific combinations of mutations causing PCD

Development and first results of the BEAT-PCD international Primary CiliaryDyskinesia gene variant database: CiliaVar

International audienceAim: To establish an online open database registering mutations and specific combinations of mutations causing PCD

Infertility in an adult cohort with primary ciliary dyskinesia: phenotype–gene association

International audienc