Synthesis, characterisation and thermal degradation behaviour of some coordination polymers by using TG–DTG and DTA techniques

The four chelate polymer complexes commonly called as coordination polymers of Mn(II), Co(II), Ni(II) and Cu(II) ions with fbpmpc (fbpmpc = fumaroyl bis (paramethoxyphenylcarbamide)) were synthesized and characterised by elemental analyses, infrared spectroscopy, diffuse reflectance, magnetic moment susceptibility, thermal analysis, X-ray diffraction, electrical conductivity and scanning electron microscopy technique (SEM). SEM investigations of coordination polymers were found in different shapes and sizes, though they are synthesized from a single ligand. Each metal ion is coordinated by a bis (bidentate) manner through oxygen atom of the carboxylato group and the nitrogen atom of an amide group of ligand and two aqua ligands by coordinated bond which formed 6-member heterocyclic ring. In the present article, the main aim of research study is to find out the comparative studies of coordination polymers such as thermogravimetry (TG), derivative thermogravimetry (DTG), differential thermal analysis (DTA), electrical conductivity and morphology behaviour. Furthermore, the electrical conductivities of chelating ligand and coordination polymers were determined in the solid state powder form. The electrical conductivities measurements of undoped and doped ligand, coordination polymers were carried out at room temperature by the four probe technique using an electrometer. Thermal degradation studies of the coordination polymers have been carried out from a non-isothermal condition under nitrogen atmosphere at a heating rate of 10 °C min−1. The decomposition steps and thermal stabilities of these complexes were confirmed by thermal analysis techniques (TG/DTG/DTA). The thermal studies inferred the presence of crystallized water in all coordination polymers, whereas coordinated water was found in Ni(II) and Cu(II) ions

Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease

Increased hepatocyte apoptosis is a hallmark of nonalcoholic fatty liver disease (NAFLD) and contributes to the profibrogenic state responsible for the progression to nonalcoholic steatohepatitis (NASH). Strategies aimed at reducing apoptosis may result in better outcomes for individuals with NAFLD. We therefore examined the effect of a short-term exercise program on markers of apoptosis—plasma cytokeratin 18 (CK18) fragments, alanine aminotransferase (ALT), aspartate aminotransferase (AST), soluble Fas (sFas), and sFas ligand (sFasL)—in 13 obese individuals with NAFLD [body mass index 35.2 ± 1.2 kg/m(2), >5% intrahepatic lipid (IHL) assessed by (1)H-MR spectroscopy]. Exercise consisted of treadmill walking for 60 min/day on 7 consecutive days at ∼85% of maximal heart rate. Additionally, subjects underwent an oral glucose tolerance test and a maximal oxygen consumption (V̇o(2max)) test before and after the exercise intervention. The Matsuda index was used to assess insulin sensitivity. We observed significant decreases in CK18 fragments (558.4 ± 106.8 vs. 323.4 ± 72.5 U/l, P < 0.01) and ALT (30.2 ± 5.1 vs. 24.3 ± 4.8 U/l, P < 0.05), and an increase in whole body fat oxidation (49.3 ± 6.1 vs. 69.4 ± 7.1 mg/min, P < 0.05), while decreases in circulating sFasL approached statistical significance (66.5 ± 6.0 vs. 63.0 ± 5.7 pg/ml, P = 0.06), as did the relationship between percent change in circulating CK18 fragments and ALT (r = 0.55, P = 0.05). We also observed a significant correlation between changes in fat oxidation and circulating sFasL (rho = −0.65, P < 0.05). There was no change in IHL following the intervention (18.2 ± 2.5 vs. 17.5 ± 2.1%, NS). We conclude that short-term exercise reduces a circulatory marker of hepatocyte apoptosis in obese individuals with NAFLD and propose that changes in the proapoptotic environment may be mediated through improved insulin sensitivity and increased oxidative capacity

Data_Sheet_1_A cross-sectional study of knowledge, attitude, and practice toward COVID-19 in solid organ transplant recipients at a transplant center in the United States.pdf

ObjectivesKnowledge, attitude, and practices (KAP) have been widely used during times of pandemic to quantify and locate gaps of care during pandemics. Using this tool, we can identify and target populations who underwent solid organ transplant (SOT) to bolster preventative practices in these patients during COVID-19.Materials and methodsAn institution-based cross-sectional study was conducted between June 1, 2020 and June 30, 2021 on patients who underwent a liver and/or kidney transplant at Methodist Dallas Medical Center in Dallas, Texas, USA. A KAP questionnaire of 26 questions about COVID-19 was designed based on the clinical and community management guidelines published by the WHO. The participant's overall KAP was categorized using Bloom's cut-off point. A KAP domain was considered sufficient if the score was between 60 and 100% and insufficient if the score was ResultsRespondents with children in the household were less likely to have sufficient practices than those who did not [OR = 0.2491, 95% Confidence Interval (0.0893–0.6120), p = 0.001]. We also found that sufficient levels of knowledge correlated with higher likelihood of sufficient levels of practices [OR = 4.94, 95% CI (1.646–14.2159), p ConclusionOur study found that knowledge and having children in the household correlated with higher levels of practice.</p