Genome-scale deconvolution of RNA structure ensembles

RNA structure heterogeneity is a major challenge when querying RNA structures with chemical probing. We introduce DRACO, an algorithm for the deconvolution of coexisting RNA conformations from mutational profiling experiments. Analysis of the SARS-CoV-2 genome using dimethyl sulfate mutational profiling with sequencing (DMS-MaPseq) and DRACO, identifies multiple regions that fold into two mutually exclusive conformations, including a conserved structural switch in the 3' untranslated region. This work may open the way to dissecting the heterogeneity of the RNA structurome

Gray matter imaging in multiple sclerosis: what have we learned?

At the early onset of the 20th century, several studies already reported that the gray matter was implicated in the histopathology of multiple sclerosis (MS). However, as white matter pathology long received predominant attention in this disease, and histological staining techniques for detecting myelin in the gray matter were suboptimal, it was not until the beginning of the 21st century that the true extent and importance of gray matter pathology in MS was finally recognized. Gray matter damage was shown to be frequent and extensive, and more pronounced in the progressive disease phases. Several studies subsequently demonstrated that the histopathology of gray matter lesions differs from that of white matter lesions. Unfortunately, imaging of pathology in gray matter structures proved to be difficult, especially when using conventional magnetic resonance imaging (MRI) techniques. However, with the recent introduction of several more advanced MRI techniques, the detection of cortical and subcortical damage in MS has considerably improved. This has important consequences for studying the clinical correlates of gray matter damage. In this review, we provide an overview of what has been learned about imaging of gray matter damage in MS, and offer a brief perspective with regards to future developments in this field

Ansia, fobie e attacchi di panico

Il capitolo descrive le sindromi cliniche che il DSM-IV TR raggruppa sotto l’etichetta di Disturbi d’Ansia e i criteri diagnostici dei vari disturbi proposti da questo manuale. Vengono quindi illustrati i principali modelli dinamici tesi a spiegare il fenomeno dell’angoscia e la patogenesi dei vari disturbi d’ansia, soffermandosi in modo particolare su quelli di derivazione freudiana e kleiniana

I disturbi dell'umore

Il capitolo descrive le sindromi cliniche che il DSM-IV TR raggruppa sotto l’etichetta di Disturbi dell’Umore e i criteri diagnostici dei vari disturbi proposti da questo manuale. Vengono quindi illustrati i diversi tipi di oscillazione dell’umore e i i principali modelli dinamici tesi a spiegare la patogenesi dei vari disturbi dell’umore, soffermandosi in modo particolare su quelli di derivazione freudiana e kleiniana

RNA Post-Transcriptional Modification Mapping Data Analysis Using RNA Framework

RNA post-transcriptional modifications (PTMs) are progressively gaining relevance in the study of coding-independent functions of RNA. RNA PTMs act as dynamic regulators of several aspects of the RNA physiology, from translation to half-life. Rising interest is supported by the advance of high-throughput techniques enabling the detection of these modifications on a transcriptome-wide scale. To this end, here we illustrate the usefulness of RNA Framework, a comprehensive toolkit for the analysis of RNA PTM mapping experiments, by reanalyzing two published transcriptome-scale datasets of N1-methyladenosine (m1A) and pseudouridine (Ψ) mapping, based on two different experimental strategies

Localizability in κ -Minkowski spacetime

Using the methods of ordinary quantum mechanics, we study κ-Minkowski space as a quantum space described by noncommuting self-adjoint operators, following and enlarging T. Poulain and J.-C. Wallet, "κ-Poincaré invariant orientable field theories with at 1-loop: Scale-invariant couplings, preprint (2018), arXiv:1808.00350 [hep-th]. We see how the role of Fourier transforms is played in this case by Mellin transforms. We briefly discuss the role of transformations and observers

The Weyl-Mellin quantization map

In this paper, we present a quantization of the functions of spacetime, i.e. a map, analog to Weyl map, which reproduces the κ-Minkowski commutation relations, and it has the desirable properties of mapping square integrable functions into Hilbert-Schmidt operators, as well as real functions into symmetric operators. The map is based on Mellin transform on radial and time coordinates. The map also defines a deformed - product which we discuss with examples