Improving the Downwind Sail Design Process by Means of a Novel FSI Approach

The process of designing a sail can be a challenging task because of the difficulties in predicting the real aerodynamic performance. This is especially true in the case of downwind sails, where the evaluation of the real shapes and aerodynamic forces can be very complex because of turbulent and detached flows and the high-deformable behavior of structures. Of course, numerical methods are very useful and reliable tools to investigate sail performances, and their use, also as a result of the exponential growth of computational resources at a very low cost, is spreading more and more, even in not highly competitive fields. This paper presents a new methodology to support sail designers in evaluating and optimizing downwind sail performance and manufacturing. A new weakly coupled fluid–structure interaction (FSI) procedure has been developed to study downwind sails. The proposed method is parametric and automated and allows for investigating multiple kinds of sails under different sailing conditions. The study of a gennaker of a small sailing yacht is presented as a case study. Based on the numerical results obtained, an analytical formulation for calculating the sail corner loads has been also proposed. The novel proposed methodology could represent a promising approach to allow for the widespread and effective use of numerical methods in the design and manufacturing of yacht sails

Parametric Hull Design with Rational Bézier Curves and Estimation of Performances

In this paper, a tool able to support the sailing yacht designer during the early stage of the design process has been developed. Cubic Rational Bézier curves have been selected to describe the main curves defining the hull of a sailing yacht. The adopted approach is based upon the definition of a set of parameters, say the length of waterline, the beam of the waterline, canoe body draft and some dimensionless coefficients according to the traditional way of the yacht designer. Some geometrical constraints imposed on the curves (e.g., continuity, endpoint angles, curvature) have been conceived aimed to avoid unreasonable shapes. These curves can be imported into any commercial Computer Aided Design (CAD) software and used as a frame to fit with a surface. The resistance of the hull can be calculated and plotted in order to have a real time estimation of the performances. The algorithm and the related Graphical User Interface (GUI) have been written in Visual Basic for Excel. To test the usability and the precision of the tool, two existing sailboats with different characteristics have been successfully replicated and a new design, taking advantages of both the hulls, has been developed. The new design shows good performances in terms of resistance values in a wide range of Froude numbers with respect to the original hulls

A co-alteration parceling of the cingulate cortex

The cingulate cortex is known to be a complex structure, involved in several cognitive and emotional functions, as well as being altered by a variety of brain disorders. This heterogeneity is reflected in the multiple parceling models proposed in the literature. At the present, sub-regions of the cingulate cortex had been identified taking into account functional and structural connectivity, as well as cytological and electrochemical properties. In the present work, we propose an innovative node-wise parceling approach based on meta-analytic Bayesian co-alteration. To this aim, 193 case–control voxel-based morphometry experiments were analyzed, and the Patel’s κ index was used to assess probability of morphometric co-alteration between nodes placed in the cingulate cortex and in the rest of the brain. Hierarchical clustering was then applied to identify nodes in the cingulate cortex exhibiting a similar pattern of whole-brain co-alteration. The obtained dendrogram highlighted a robust fronto-parietal cluster compatible with the default mode network, and being supported by the interplay between the retrosplenial cortex and the anterior and posterior cingulate cortex, rarely described in the literature. This ensemble was further confirmed by the analysis of functional patterns. Leveraging on co-alteration to investigate cortical organization could, therefore, allow to combine multimodal information, resolving conflicting results sometimes coming from the separate use of singular modalities. Crucially, this provides a valuable way to understand the pathological brain using data driven, whole-brain informed and context-specific evidence in a way not yet explored in the field. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-022-02473-2

Sex differences in brain homotopic co-activations: a meta-analytic study

An element of great interest in functional connectivity is ‘homotopic connectivity’ (HC), namely the connectivity between two mirrored areas of the two hemispheres, mainly mediated by the fibers of the corpus callosum. Despite a long tradition of studying sexual dimorphism in the human brain, to our knowledge only one study has addressed the influence of sex on HC. We investigated the issue of homotopic co-activations in women and men using a coordinate-based meta-analytic method and data from the BrainMap database. A first unexpected observation was that the database was affected by a sex bias: women-only groups are investigated less often than men-only ones, and they are more often studied in certain domains such as emotion compared to men, and less in cognition. Implementing a series of sampling procedures to equalize the size and proportion of the datasets, our results indicated that females exhibit stronger interhemispheric co-activation than males, suggesting that the female brain is less lateralized and more integrated than that of males. In addition, males appear to show less intense but more extensive co-activation than females. Some local differences also appeared. In particular, it appears that primary motor and perceptual areas are more co-activated in males, in contrast to the opposite trend in the rest of the brain. This argues for a multidimensional view of sex brain differences and suggests that the issue should be approached with more complex models than previously thought. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-022-02572-0

Linking neuroanatomical abnormalities in autism spectrum disorder with gene expression of candidate ASD genes: A meta-analytic and network-oriented approach

BACKGROUND: Autism spectrum disorder (ASD) is a set of developmental conditions with widespread neuroanatomical abnormalities and a strong genetic basis. Although neuroimaging studies have indicated anatomical changes in grey matter (GM) morphometry, their associations with gene expression remain elusive. METHODS: Here, we aim to understand how gene expression correlates with neuroanatomical atypicalities in ASD. To do so, we performed a coordinate-based meta-analysis to determine the common GM variation pattern in the autistic brain. From the Allen Human Brain Atlas, we selected eight genes from the SHANK, NRXN, NLGN family and MECP2, which have been implicated with ASD, particularly in regards to altered synaptic transmission and plasticity. The gene expression maps for each gene were built. We then assessed the correlation between the gene expression maps and the GM alteration maps. Lastly, we projected the obtained clusters of GM alteration-gene correlations on top of the canonical resting state networks, in order to provide a functional characterization of the structural evidence. RESULTS: We found that gene expression of most genes correlated with GM alteration (both increase and decrease) in regions located in the default mode network. Decreased GM was also correlated with gene expression of some ASD genes in areas associated with the dorsal attention and cerebellar network. Lastly, single genes were found to be significantly correlated with increased GM in areas located in the somatomotor, limbic and ganglia/thalamus networks. CONCLUSIONS: This approach allowed us to combine the well beaten path of genetic and brain imaging in a novel way, to specifically investigate the relation between gene expression and brain with structural damage, and individuate genes of potential interest for further investigation in the functional domain

Gray matter abnormalities follow non-random patterns of co-alteration in autism: Meta-connectomic evidence

•We present an innovative connectomic approach based on voxel-based morphometry (VBM) meta-data.•We mapped the topological configuration of gray matter abnormalities in autism spectrum disorder (ASD).•ASD co-alteration network tends to overlap with the pathways of structural brain connectivity.•Recognizable cerebral pathological hubs were captured by graph-analysis.•A core sub-network was identified, which provides insight into our understanding of ASD. Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by atypical brain anatomy and connectivity. Graph-theoretical methods have mainly been applied to detect altered patterns of white matter tracts and functional brain activation in individuals with ASD. The network topology of gray matter (GM) abnormalities in ASD remains relatively unexplored. An innovative meta-connectomic analysis on voxel-based morphometry data (45 experiments, 1,786 subjects with ASD) was performed in order to investigate whether GM variations can develop in a distinct pattern of co-alteration across the brain. This pattern was then compared with normative profiles of structural and genetic co-expression maps. Graph measures of centrality and clustering were also applied to identify brain areas with the highest topological hierarchy and core sub-graph components within the co-alteration network observed in ASD. Individuals with ASD exhibit a distinctive and topologically defined pattern of GM co-alteration that moderately follows the structural connectivity constraints. This was not observed with respect to the pattern of genetic co-expression. Hub regions of the co-alteration network were mainly left-lateralized, encompassing the precuneus, ventral anterior cingulate, and middle occipital gyrus. Regions of the default mode network appear to be central in the topology of co-alterations. These findings shed new light on the pathobiology of ASD, suggesting a network-level dysfunction among spatially distributed GM regions. At the same time, this study supports pathoconnectomics as an insightful approach to better understand neuropsychiatric disorders

A deep learning approach for Spatio-Temporal forecasting of new cases and new hospital admissions of COVID-19 spread in Reggio Emilia, Northern Italy

Since February 2020, the COVID-19 epidemic has rapidly spread throughout Italy. Some studies showed an association of environmental factors, such as PM10, PM2.5, NO2, temperature, relative humidity, wind speed, solar radiation and mobility with the spread of the epidemic. In this work, we aimed to predict via Deep Learning the real-time transmission of SARS-CoV-2 in the province of Reggio Emilia, Northern Italy, in a grid with a small resolution (12 km × 12 km), including satellite information

Acceleration of Solar Energetic Particles through CME-driven Shock and Streamer Interaction

On 2013 June 21, a solar prominence eruption was observed, accompanied by an M2.9 class flare, a fast coronal mass ejection, and a type II radio burst. The concomitant emission of solar energetic particles (SEPs) produced a significant proton flux increase, in the energy range 4-100 MeV, measured by the Low and High Energy Telescopes on board the Solar TErrestrial RElations Observatory (STEREO)-B spacecraft. Only small enhancements, at lower energies, were observed at the STEREO-A and Geostationary Operational Environmental Satellite (GOES) spacecraft. This work investigates the relationship between the expanding front, coronal streamers, and the SEP fluxes observed at different locations. Extreme-ultraviolet data, acquired by the Atmospheric Imaging Assembly (AIA) instrument on board the Solar Dynamics Observatory (SDO), were used to study the expanding front and its interaction with streamer structures in the low corona. The 3D shape of the expanding front was reconstructed and extrapolated at different times by using SDO/AIA, STEREO/Sun Earth Connection Coronal and Heliospheric Investigation, and Solar and Heliospheric Observatory/Large Angle and Spectrometric Coronagraph observations with a spheroidal model. By adopting a potential field source surface approximation and estimating the magnetic connection of the Parker spiral, below and above 2.5 R ⊙, we found that during the early expansion of the eruption, the front had a strong magnetic connection with STEREO-B (between the nose and flank of the eruption front) while having a weak connection with STEREO-A and GOES. The obtained results provide evidence, for the first time, that the interaction between an expanding front and streamer structures can be responsible for the acceleration of high-energy SEPs up to at least 100 MeV, as it favors particle trapping and hence increases the shock acceleration efficiency