Complex metabolic geroprophylaxis in older patients with polymorbidity

The purpose of the study is to detect geroprophylactic activity and its possible mechanisms under the conditions of Inosine + Nicotinamide + Riboflavin + Succinic acid (ATC Code: N07XX) use in older patients with polymorbidity.Цель исследования – обнаружить геропрофилактическую активность и возможные ее механизмы в условиях применения Инозина + Никотинамида + Рибофлавина + Янтарной кислоты; (Код АТХ: N07XX) у пациентов старшего поколения с полиморбидностью

Selective serotonin reuptake inhibitor antidepressant use in first trimester pregnancy and risk of specific congenital anomalies: A European register-based study

Evidence of an association between early pregnancy exposure to selective serotonin reuptake inhibitors (SSRI) and congenital heart defects (CHD) has contributed to recommendations to weigh benefits and risks carefully. The objective of this study was to determine the specificity of association between first trimester exposure to SSRIs and specific CHD and other congenital anomalies (CA) associated with SSRI exposure in the literature (signals). A population-based case-malformed control study was conducted in 12 EUROCAT CA registries covering 2.1 million births 1995-2009 including livebirths, fetal deaths from 20 weeks gestation and terminations of pregnancy for fetal anomaly. Babies/fetuses with specific CHD (n = 12,876) and non-CHD signal CA (n = 13,024), were compared with malformed controls whose diagnosed CA have not been associated with SSRI in the literature (n = 17,083). SSRI exposure in first trimester pregnancy was associated with CHD overall (OR adjusted for registry 1.41, 95% CI 1.07-1.86, fluoxetine adjOR 1.43 95% CI 0.85-2.40, paroxetine adjOR 1.53, 95% CI 0.91-2.58) and with severe CHD (adjOR 1.56, 95% CI 1.02-2.39), particularly Tetralogy of Fallot (adjOR 3.16, 95% CI 1.52-6.58) and Ebstein's anomaly (adjOR 8.23, 95% CI 2.92-23.16). Significant associations with SSRI exposure were also found for ano-rectal atresia/stenosis (adjOR 2.46, 95% CI 1.06-5.68), gastroschisis (adjOR 2.42, 95% CI 1.10-5.29), renal dysplasia (adjOR 3.01, 95% CI 1.61-5.61), and clubfoot (adjOR 2.41, 95% CI 1.59-3.65). These data support a teratogenic effect of SSRIs specific to certain anomalies, but cannot exclude confounding by indication or associated factors

SPACE-TIME ANALYSIS OF DISTURBANCES IN THE PC4-5 PERIOD RANGE DURING MAGNETIC STORMS BY CORRELATION-SKELETON METHOD

Special method of correlation-skeleton processing of long period MHD disturbed components of the geomagnetic field is developed. To analyze space-time distribution for field components recorded along the meridian 210 at different stages of geomagnetic storms it is applied. This method on the base of post-processing of space-time wavelet analysis of disturbances was performed. The proposal of spectra calculation results in the form of wavelet skeleton pictures is shown. The method allows to find synchronization of oscillatory processes along the geomagnetic meridian and use it as indication of a global magnetic disturbance. Developed algorithm as a diagnostic tool state of the magnetosphere can also be used. The proposed method in this study the correlation processing of long-skeleton perturbation MHD range component of the geomagnetic field detects synchronization of oscillatory processes along the geomagnetic meridian. This makes it possible to establish the spatial and temporal distribution of low-frequency disturbances during magnetic storms. The results of this approach can be used for short-term forecast of the global magnetic disturbance